Formation of the definitive endoderm in mouse is a Smad2-dependent process

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Alexandrow, M. G. and Moses, H. L (1995). Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1independent of effects on gene transcription. Cancer Res 55, 3928-3932.[Abstract/Free Full Text]

Ang, S. L., Conlon, R. A., Jin, O. and Rossant, J (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.[Abstract]

Bachiller, D., Klingensmith, J., Kemp, C., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J., et al., (2000). The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403, 658-661.[Medline]

Baker, J. C. and Harland, R. M (1996). A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev 10, 1880-1889.[Abstract/Free Full Text]

Barnes, J. D., Crosby, J. L., Jones, C. M., Wright, C. V. and Hogan, B. L. M (1994). Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol 161, 168-178.[Medline]

Beddington, R. S. P. and Robertson, E. J (1998). Anterior patterning in mouse. Trends Genet 14, 277-284.[Medline]

Beddington, R. S. P. and Robertson, E. J (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.[Medline]

Beddington, R. S. P. and Robertson, E. J (1989). An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105, 733-737.[Abstract/Free Full Text]

Bedford, F. K., Ashworth, A., Enver, T. and Wiedemann, L. M (1993). HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucl. Acids Res 21, 1245-1249.[Abstract/Free Full Text]

Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M. and De Robertis, E. M (1997). Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev 68, 45-57.[Medline]

Bielinska, M., Narita, N. and Wilson, D. B (1999). Distinct roles for visceral endoderm during embryonic mouse development. Int. J. Dev. Biol 43, 183-205.[Medline]

Chang, H., Huylebroek, D., Verschueren, K., Guo, Q., Matzuk, M. M. andZwijsen, A (1999). Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126, 1631-1642.[Abstract]

Chazaud, C. P., Chambon and Dolle, P (1999). Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 126, 2589-2596.[Abstract]

Chen, X., Rubock, M. J. and Whitman, M (1996). A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383, 691-696.[Medline]

Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G. and Whitman, M (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-9.[Medline]

Clements, D., Friday, R. V. and Woodland, H. R (1999). Mode of action of VegT in mesoderm and endoderm formation. Development 126, 4903-4911.[Abstract]

Collignon, J., Varlet, I. and Robertson, E. J (1996). Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155-158.[Medline]

Constam, D. B. and Robertson, E. J (2000). Tissue-specific requirements for the proprotein convertase Furin/SPC1 during embryonic turning and heart looping. Development 127, 245-254.[Abstract]

Dale, J. K., Vesque, C., Lints, T. J., Sampath, T. K., Furley, A., Dodd, J. and Placzek, M (1997). Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell 90, 257-269.[Medline]

Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y. and Wang, X. F (1999). Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol. Cell. Biol 19, 2495-2504.[Abstract/Free Full Text]

Derynck, R., Zhang, Y. and Feng, X.-H (1998). Smads: Transcriptional Activators of TGF-Responses. Cell 95, 737-740.[Medline]

Dick, A., Risau, W. and Drexler, H (1998). Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development. Dev. Dyn 211, 293-305.[Medline]

Dufort, D., Schwartz, L., Harpal, K. and Rossant, J (1998). The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development 125, 3015-3025.[Abstract]

Ecochard, V., Cayrol, C., Rey, S., Foulquier, F., Caillol, D., Lemaire, P. and Duprat, A. M (1998). A novel Xenopus Mix-like gene milk involved in the control of the endomesodermal fates. Development 125, 2577-2585.[Abstract]

Farrington, S. M., Belaoussoff, M. and Baron, M. H (1997). Winged helix , Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech. Dev 62, 197-211.[Medline]

Feldman, B., Gates, M. A., Egan, E. S., Dougan, S. T., Rennebeck, G., Sirotkin, H. I., Schier, A. F. and Talbot, W. S (1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395, 181-185.[Medline]

Foley, A. C., Storey, K. G. and Stern, C. D (1997). The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium. Development 124, 2983-2996.[Abstract]

Friedrich, G. and Soriano, P (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes. Genes Dev 5, 1513-1523.[Abstract/Free Full Text]

Germain, S., Howell, M., Esslemont, G. M. and Hill, C. S (2000). Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev 14, 435-451.[Abstract/Free Full Text]

Graff, J. M., Bansal, A. and Melton, D. A (1996). Xenopus Mad protein transduce distinct subsets of signals for the TGFbeta superfamily. Cell 85, 479-487.[Medline]

Gu, Z., Nomura, M., Simpson, B. B., Lei, H., Feijen, A., van den Eijnden-van Raaij, J., Donahoe, P. K. and Li, E (1998). The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev 12, 844-857.[Abstract/Free Full Text]

Gu, Z., Reynolds, E. M., Song, J., Lei, H., Feijen, A., Yu, L., He, W., MacLaughlin, D. T., van den Eijnden-van Raaij, J., Donahoe, P. K., et al., (1999). The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 126, 2552-2561.

Harland, R. and Gerhart, J (1997). Formation and function of Spemann's organizer. Annu. Rev. Cell Dev. Biol 13, 611-667.[Medline]

Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati-Brivanlou, A. and Massague, J (2000). OAZ uses distinct DNA-and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100, 229-240.[Medline]

Henry, G. L. and Melton, D. A (1998). Mixer, a homeobox gene required for endoderm development. Science 28, 91-96.

Heyer, J., Escalante-Alcalde, D., Lia, M., Boettinger, E., Edelmann, W., Stewart, C. L. and Kucherlapati, R (1999). Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc. Nat. Acad. Sci. USA 96, 12595-12600.[Abstract/Free Full Text]

Hogan, B. L. M (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10, 1580-1594.[Free Full Text]

Howell, M. and Hill, C. S (1997). XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J 16, 7411-7421.[Medline]

Hudson, C., Clements, D., Friday, R. V., Stott, D. and Woodland, H. R (1997). Xsox17alpha andbeta mediate endoderm formation in Xenopus. Cell 91, 397-405.[Medline]

Izraeli, S., Lowe, L. A., Bertness, V. L., Good, D. J., Dorward, D. W., Kirsch, I. R. and Kuehn, M. R (1999). The SIL gene is required for mouse embryonic axial development and left-right specification. Nature 399, 691-694.[Medline]

Jones, C. M., Lyons, K. M. and Hogan, B. L. M (1991). Involvement of of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111, 531-542.[Abstract]

Kofron, M., Demel, T., Xanthos, J., Lohr, J., Sun, B., Sive, H., Osada, S.-I., Wright, C., Wylie, C. and Heasman, J (1999). Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFgrowth factors. Development 126, 5759-5770.[Abstract]

Labbe, E., Silvestri, C., Hoodless, P. A., Wrana, J. L. and Attisano, L (1998). Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2, 109-120.

Lawson, K. A., Meneses, J. J. and Pedersen, R. A (1986). Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer. Dev. Biol 115, 325-339.[Medline]

Lawson, K. A., Meneses, J. J. and Pedersen, R. A (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.[Abstract]

Lawson, K. A. and Pedersen, R. A (1987). Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101, 627-652.[Abstract]

Lebrun, J. J., Takabe, K., Chen, Y. and Vale, W (1999). Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol. Endocrinol 13, 15-23.[Abstract/Free Full Text]

Lemaire, P., Darras, S., Caillol, D. and Kodjabachian, L (1998). A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone. Development 125, 2371-2380.[Abstract]

Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H. and Hamada, H (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.[Medline]

Meyers, E. N. and Martin, G. R (1999). Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285, 403-406.[Abstract/Free Full Text]

Nomura, M. and Li, E (1998). Smad2 role in mesodern formation, left-right patterning and craniofacial development. Nature 393, 786-790.[Medline]

Norris, D. P. and Robertson, E. J (1999). Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. Genes Dev 13, 1575-1588.[Abstract/Free Full Text]

Osada, S.-H. and Wright, C. V. E (1999). Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development 126, 3229-3240.[Abstract]

Perea-Gomez, A., Shawlot, W., Sasaki, H., Behringer, R. R. and Ang, S.-L (1999). HNF3and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126, 4499-4511.[Abstract]

Peyrieras, N., Strahle, U. and Rosa, F (1998). Conversion of zebrafishblastomeres to an endodermal fate by TGF--related signalling. Curr. Biol 8, 783-786.[Medline]

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E. M (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-70.[Medline]

Rebbert, M. L. and Dawid, I. B (1997). Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I. Proc. Nat. Acad. Sci. USA 94, 9717-9722.[Abstract/Free Full Text]

Roberts, A. B. and Sporn, M. B (1993). Physiological actions and clinical applications of transforming growth factor-beta (TGF-). Growth Factors 8, 1-9.[Medline]

Ryan, A. K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Pe\361a, J., Sabbagh, W., Greenwald, J., Choe, S., et al., (1998). Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-551.[Medline]

Saijoh, Y., Adachi, H., Sakuma, R., Yeol-yeo, C., Watanabe, M., Hashiguchi, H., Mochida, K., Ohiahi, S., Kawabata, M., Miyazono, K., et al., (2000). Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell 5, 35-47.

Sasaki, H. and Hogan, B. L. M (1994). HNF-3 beta as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Schier, A. F. and Shen, M. M (2000). Nodal signalling in vertebrate development. Nature 403, 385-389.[Medline]

Shawlot, W., Wakamiya, M., Kwan, K. M., Kania, A., Jessell, T. M. and Behringer, R. R (1999). Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. Development 126, 4925-4932.[Abstract]

Sirard, C., de le Pompa, J. L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S. E., et al., (1998). The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and laterfor anterior development of the mouse embryo. Genes Dev 12, 107-119.[Abstract/Free Full Text]

Solloway, M. J. and Robertson, E. J (1999). Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggest functional redundancy withing the 60A subgroup. Development 126, 1753-1738.[Abstract]

Sun, B. I., Bush, S. M., Collins-Racie, L. A., LaVallie, E. R., DiBlasio-Smith, E. A., Wolfman, N. M., McCoy, J. M. and Sive, H. L (1999). derriere: a TGF-beta family member required for posterior development in Xenopus. Development 126, 1467-1482.[Abstract]

Tam, P. P. and Beddington, R. S.P (1992). Establishment and organization of germ layers in the gastrulating mouse embryo. Ciba Found. Symp 165, 27-41.[Medline]

Thomas, P. and Beddington, R (1996). Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol 6, 1487-96.[Medline]

Thomas, P., Brickman, J. M., P\232pperl, H., Krumlauf, R. and Beddington, R. S.P (1997). Axis duplication and anterior identity in the mouse embryo. Cold Spring Harbor Symp. Quant. Biol 62, 115-125.[Abstract/Free Full Text]

Thomsen, G. H (1996). Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122, 2359-2366.[Abstract]

Varlet, I., Collignon, J. and Robertson, E. J (1997). Nodal expression in the primative endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124, 1033-1044.[Abstract]

Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L. and Robertson, E. J (1998). Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808.[Medline]

Weinstein, M., Yang, X., Li, C., Xu, X., Gotay, J. and Deng, C.-X (1998). Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc. Natl. Acad. Sci. USA 95, 9378-9383.[Abstract/Free Full Text]

Wells, J. M. and Melton, D. A (1999). Vertebrate endoderm development. Ann. Rev. Cell. Dev. Biol 15, 393-410.[Medline]

Whitman, M (1998). Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev 12, 2445-2462.[Free Full Text]

Wilson, V. and Beddington, R. S. P (1996). Cell fate and morphogenetic movement in the late primitive streak. Mech. Dev 55, 79-89.[Medline]

Winnier, G, Blessing, M., Labosky, P. A., Hogan, B. L. M (1995). Bone-morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9, 2105-2116.[Abstract/Free Full Text]

Wrana, J. L (2000). Regulation of Smad activity. Cell 100, 189-192.[Medline]

Yang, X., Castilla, L. H., Xu, X., Li, C., Gotay, J., Weinstein, M., Liu, P. P. and Deng, C.-X (1999). Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development 126, 1571-1580.[Abstract]

Yang, X., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B. and Deng, C (1999). Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-. EMBO J 18, 1280-1291.[Medline]

Yang, X., Li, C., Xu, X. and Deng, C (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. USA 95, 3667-3672.[Abstract/Free Full Text]

Zarat, K (1999). Developmental competence of the gut endoderm: Genetic potentiation by GATA and HNF3/Fork Head proteins. Dev. Biol 209, 1-10.[Medline]

Zhang, H. and Bradley, A (1996). Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977-2986.[Abstract]

Zhang, Y., Feng, X.-H., Wu, R.-Y. and Derynck, R (1996). Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383, 168-172.[Medline]

Zhu, Y., Richardson, J. A., Parada, L. F. and Graff, J. M (1998). Smad3 mutant mice develop metastatic colorectal cancer. Cell 94, 703-714.[Medline]

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FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
Genes & Dev., May 15, 2001; 15(10): 1257 - 1271.
[Abstract] [Full Text]

S. K. Kim and M. Hebrok
Intercellular signals regulating pancreas development and function
Genes & Dev., January 15, 2001; 15(2): 111 - 127.
[Full Text]

L. Lowe, S Yamada, and M. Kuehn
Genetic dissection of nodal function in patterning the mouse embryo
Development, January 5, 2001; 128(10): 1831 - 1843.
[Abstract] [PDF]

J.-F. Pare, S. Roy, L. Galarneau, and L. Belanger
The Mouse Fetoprotein Transcription Factor (FTF) Gene Promoter Is Regulated by Three GATA Elements with Tandem E Box and Nkx Motifs, and FTF in Turn Activates the Hnf3beta , Hnf4alpha , and Hnf1alpha Gene Promoters
J. Biol. Chem., April 13, 2001; 276(16): 13136 - 13144.
[Abstract] [Full Text] [PDF]

L. Ulloa and S. Tabibzadeh
Lefty Inhibits Receptor-regulated Smad Phosphorylation Induced by the Activated Transforming Growth Factor-beta Receptor
J. Biol. Chem., June 8, 2001; 276(24): 21397 - 21404.
[Abstract] [Full Text] [PDF]

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