Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities

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Akimaru, H., Chen, Y., Dai, P., Hou, D. X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. H. and Ishii, S (1997). Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386, 735-8.[Medline]

Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-13.[Abstract/Free Full Text]

Alves, G., Limbourg-Bouchon, B., Tricoire, H., Brissard-Zahraoui, J., Lamour-Isnard, C. and Busson, D (1998). Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech. Dev 78, 17-31.[Medline]

Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-53.[Medline]

Biesecker, L. G (1997). Strike three for GLI3. Nature Genet 17, 259-60.[Medline]

Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. and Gelbart, W. M (1991). An extensive 3cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila. Development 111, 657-666.[Abstract]

Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Brewster, R., Lee, J. and Ruiz i Altaba, A (1998). Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature 393, 579-83.[Medline]

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev 62, 175-82.[Medline]

Buscher, D. and Ruther, U (1998). Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev. Dyn 211, 88-96.[Medline]

Capdevila, J., Estrada, M. P., Sanchez-Herrero, E. and Guerrero, I (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13, 71-82.[Medline]

Chen, C. H., von Kessler, D. P., Park, W., Wang, B., Ma, Y. and Beachy, P. A (1999). Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98, 305-16.[Medline]

Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem 274, 8143-52.[Abstract/Free Full Text]

Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-43.[Abstract]

Dom\222nguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-25.[Abstract]

Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. and Orenic, T. V (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-58.[Abstract]

Hui, C. C., Slusarski, D., Platt, K. A., Holmgren, R. and Joyner, A. L (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol 162, 402-13.[Medline]

Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.[Medline]

Johnson, R. L., Grenier, J. K. and Scott, M. P (1995). patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121, 4161-70.[Abstract]

Lee, J., Platt, K. A., Censullo, P. and Ruiz i Altaba, A (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-52.[Abstract]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol 180, 273-83.[Medline]

Maschat, F., Serrano, N., Randsholt, N. B. and Geraud, G (1998). engrailed and polyhomeotic interactions are required to maintain the A/P boundary of the Drosophila developing wing. Development 125, 2771-80.[Abstract]

Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-70.[Abstract]

Mering, C. v. and Basler, K (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Current Biol 9, 1319-1322.[Medline]

Methot, N. and Basler, K (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-31.[Medline]

Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C. and Plessis, A (1998). Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Current Biology 8, 583-6.[Medline]

Ohlmeyer, J. T. and Kalderon, D (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-53.[Medline]

Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashiima, M. and Joyner, A. L (2000). Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605.[Abstract]

Pearse, R. V., 2nd, Collier, L. S., Scott, M. P. and Tabin, C. J (1999). Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev. Biol 212, 323-36.[Medline]

Ramirez-Weber, F. A. and Kornberg, T. B (1999). Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell 97, 599-607.[Medline]

Robbins, D. J., Nybakken, K. E., Kobayashi, R., Sisson, J. C., Bishop, J. M. and Therond, P. P (1997). Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90, 225-34.[Medline]

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor Miklos, G. L., Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W. et al. ( (2000). Comparative genomics of the eukaryotes. Science 287, 2204-15.[Abstract/Free Full Text]

Ruiz i Altaba, A (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-12.[Abstract]

Ruiz i Altaba, A (1999). Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216.[Abstract]

Sasaki, H., Hui, C., Nakafuku, M. and Kondoh, H (1997). A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-22.[Abstract]

Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. and Kondoh, H (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-24.[Abstract]

Shin, S. H., Kogerman, P., Lindstrom, E., Toftgard, R. and Biesecker, L. G (1999). GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc. Natl Acad. Sci. USA 96, 2880-4.[Abstract/Free Full Text]

Sisson, J. C., Ho, K. S., Suyama, K. and Scott, M. P (1997). Costal2, a novel kinesin-related protein in the Hedgehog/Patched signaling pathway. Cell 90, 235-245.[Medline]

Stone, D. M., Murone, M., Luoh, S.-M., Ye, W., Armamini, M. P., Gurney, A., Phillips, H., Grush, J., Goddard, A., de Sauvage, F. J. et al. ( (1999). Characterization of the human Suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell Sci 112, 4437-4448.[Abstract]

Stuurman, N., Delbecque, J. P., Callaerts, P. and Aebi, U (1999). Ectopic overexpression of Drosophila lamin C is stage-specific lethal. Exp. Cell Res 248, 350-7.[Medline]

Therond, P. P., Knight, J. D., Kornberg, T. B. and Bishop, J. M (1996). Phosphorylation of the fused protein in response to signaling from hedgehog. Proc. Nat. Acad. Sci. USA 93, 4224-8.[Abstract/Free Full Text]

Wang, B., Fallon, J. F. and Beachy, P. A (2000). Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-34.[Medline]

Wang, G., Wang, B. and Jiang, J (1999). Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev 13, 2828-2837.[Abstract/Free Full Text]

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				A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation Development, January 15, 2005; 132(2): 345 - 357. [Abstract] [Full Text] [PDF]

				G. Regl, M. Kasper, H. Schnidar, T. Eichberger, G. W. Neill, M. P. Philpott, H. Esterbauer, C. Hauser-Kronberger, A.-M. Frischauf, and F. Aberger Activation of the BCL2 Promoter in Response to Hedgehog/GLI Signal Transduction Is Predominantly Mediated by GLI2 Cancer Res., November 1, 2004; 64(21): 7724 - 7731. [Abstract] [Full Text] [PDF]

				B. Ganss and A. Jheon ZINC FINGER TRANSCRIPTION FACTORS IN SKELETAL DEVELOPMENT Crit. Rev. Oral. Biol. Med., September 1, 2004; 15(5): 282 - 297. [Abstract] [Full Text] [PDF]

				Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord Development, August 1, 2004; 131(15): 3593 - 3604. [Abstract] [Full Text] [PDF]

				K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]

				E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features PNAS, November 11, 2003; 100(23): 13424 - 13429. [Abstract] [Full Text] [PDF]

				R. Sacedon, A. Varas, C. Hernandez-Lopez, C. Gutierrez-deFrias, T. Crompton, A. G. Zapata, and A. Vicente Expression of Hedgehog Proteins in the Human Thymus J. Histochem. Cytochem., November 1, 2003; 51(11): 1557 - 1566. [Abstract] [Full Text] [PDF]

				J. Jia, C. Tong, and J. Jiang Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail Genes & Dev., November 1, 2003; 17(21): 2709 - 2720. [Abstract] [Full Text] [PDF]

				D. O. Walterhouse, M. L.G. Lamm, E. Villavicencio, and P. M. Iannaccone Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction Biol Reprod, July 1, 2003; 69(1): 8 - 14. [Abstract] [Full Text] [PDF]

				R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development, April 15, 2003; 130(8): 1549 - 1564. [Abstract] [Full Text] [PDF]

				E. Roessler and M. Muenke How a Hedgehog might see holoprosencephaly Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25. [Abstract] [Full Text] [PDF]

				C. B. Bai, W. Auerbach, J. S. Lee, D. Stephen, and A. L. Joyner Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway Development, March 12, 2003; 129(20): 4753 - 4761. [Abstract] [Full Text] [PDF]

				M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]