Amaya, E., Musci, T. J. and Kirschner, M. W (1991). Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell 66, 257-270.[Medline]
Amaya, E., Stein, P. A., Musci, T. J. and Kirschner, M. W (1993). FGF signalling in the early specification of mesoderm in Xenopus. Development 118, 477-487.[Abstract]
Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]
Baker, J. C. and Harland, R. M (1996). A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev 10, 1880-1889.[Abstract/Free Full Text]
Beck, C. W. and Slack, J. M. W (1999). A developmental pathway controlling outgrowth of the Xenopus tail bud. Development 126, 1611-1620.[Abstract]
Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B. L (1997). Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124, 4867-4878.[Abstract]
Borycki, A. G., Mendham, L. and Emerson, Jr, C. P (1998). Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 125, 777-790.[Abstract]
Borycki, A-G., Brown, A. M. C. and Emerson, Jr, C. P (2000). Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development 127, 2075-2087.[Abstract]
Brewster, R., Lee, J. and Ruiz i Altaba, A (1998). Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature 393, 579-583.[Medline]
Chang, C., Wilson, P. A., Mathews, L. S. and Hemmati-Brivanlou, A (1997). A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. Development 124, 827-837.[Abstract]
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]
Cho, K. W., Blumberg, B., Steinbeisser, H. and De Robertis, E. M. ( (1991). Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.[Medline]
Conlon, F. L., Sedgwick, S. G., Weston, K. M. and Smith, J. C (1996). Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development 122, 2427-2435.[Abstract]
Cornell, R. A., Musci, T. J. and Kimelman, D. ( (1995). FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction. Development 121, 2429-2437.[Abstract]
Cunliffe, V. and Smith, J. C (1992). Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. Nature 358, 427-430.[Medline]
Dahmane, N. and Ruiz i Altaba, A (1999). Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126, 3089-3100.[Abstract]
Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by Gli3. J. Biol. Chem 274, 8143-8152.[Abstract/Free Full Text]
Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.[Abstract]
Dirksen, M. L. and Jamrich, M (1992). A novel, activin-inducible,blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Genes Dev 6, 599-608.[Abstract/Free Full Text]
Ekker, S. C., McGrew, L. L., Lai, C.-J., Lee, J. J., von Kessler, D. P., Moon, R. T. and Beachy, P. A (1995). Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. Development 121, 2337-2347.[Abstract]
Griffin, K., Patient, R. and Holder, N (1995). Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. Development 121, 2983-2994.[Abstract]
Griffin, K. J. P., Amacher, S. L., Kinnel, C. B. and Limelman, D (1998). Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development 125, 3379-3388.[Abstract]
Hollemann, T., Schuh, R., Pieler, T. and Stick, R (1996). Xenopus Xsal-1, a vertebrate homolog of the region specific homeotic gene spalt of Drosophila. Mech. Dev 55, 19-32.[Medline]
Hopwood, N. D., Pluck, A., Gurdon, J. B. and Dilworth, S. M (1992). Expression of XMyoD protein in early Xenopus laevis embryos. Development 114, 31-38.[Abstract]
Hui, C. C. and Joyner, A. L (1993). A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet 3, 241-246.[Medline]
Hynes M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli1. Neuron 19, 15-26.[Medline]
Isaacs, H. V., Pownall, M. E. and Slack, J. M (1994). eFGF regulates Xbra expression during Xenopus gastrulation. EMBO J 13, 4469-4481.[Medline]
Karlstrom, R. O., Talbot, W. S. and Schier, A. F (1999). Comparative synteny cloning of zebrafish you-too: mutations in the hedgehog target gli2 affect ventral forebrain patterning. Genes Dev 13, 388-393.[Abstract/Free Full Text]
Kohlhase, J., Schuh, R., Dowe, G., Kuhnlein, R. P., Jackle, H., Schroeder, B., Schulz-Schaeffer, W., Kretzschmar, H. A., Kohler, A., Muller, U., et al. ( (1996). Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt. Genomics 38, 291-298.[Medline]
Kohlhase, J., Wischermann, A., Reichenbach, H., Froster, U. and Engel, W (1998). Mutations in the SALL1 putative transcription factor gene cause Towned-Brocks syndrome. Nat. Genet 18, 81-83.[Medline]
Krieg, P. A., Varnum, S. M., Wormington, W. M. and Melton, D. A (1989). The mRNA encoding elongation factor 1-alpha (EF-1) is a major transcript at the midblastula transition in Xenopus. Dev. Biol 133, 93-100.[Medline]
Kroll, L. K. and Amaya, E (1996). Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation. Development 122, 3173-3183.[Abstract]
Kuhnlein, R. P., Frommer, G., Friedrich, M., Gonzalez-Gaitan, M., Weber, A., Wagner-Bernholz, J. F., Gehring, W. J., J\212ckle, H. and Schuh, R (1994). spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J 13, 168-179.[Medline]
LaBonne, C. and Whitman, M (1994). Mesoderm induction by activin requires FGF-mediated intracellular signals. Development 120, 463-472.[Abstract]
Latinkic, B. V., Umbhauer, M., Neal, K. A., Lerchner, W., Smith, J. C. and Cunliffe, V (1997). The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev 11, 3265-3276.[Abstract/Free Full Text]
Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]
Lee, C. S., Buttitta, L. A., May, N. R., Kispert, A. and Fan, C.-M (2000). SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127, 109-118.[Abstract]
Liu, F., Massague, J. and Ruiz i Altaba, A (1998). Carboxy-terminally truncated Gli3 proteins associate with Smads. Nat. Genet 20, 325-326.[Medline]
Marigo V., Johnson R. L., Vortkamp A. and Tabin, C. J (1996). Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. Dev. Biol 180, 273-283.[Medline]
Marine, J. C., Bellefroid, E. J., Pendeville, H., Martial, J. A. and Pieler, T (1997). A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm. Mech. Dev 63, 211-225.[Medline]
Matise, M. P., Lustig, M., Sakurai, T., Grumet, M. and Joyner, A. L (1999). Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development 126, 3649-3659.[Abstract]
Meyers, E. N. and Martin, G. R (1999). Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285, 403-406.[Abstract/Free Full Text]
Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H., Chik, K. W., Shi, X. M., Tsui, L. C., Cheng, S. H., et al (1997). Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113-123.[Abstract]
Munsterberg, A. E., Kitajewski, J., Bumcrot, D. A., McMahon, A. P. and Lassar, A. B (1995). Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev 9, 2911-2922.[Abstract/Free Full Text]
Murtaugh, L. C., Chyung, J. H. and Lassar, A. B (1999). Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev 13, 225-237.[Abstract/Free Full Text]
Ott, T., Kaestner, K. H., Monaghan, A. P. and Schutz, G (1996). The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures. Mech. Dev 56, 117-128.[Medline]
Park, H., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M. and Joyner, A. L (2000). Mouse Gli1 mutnats are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605.[Abstract]
Pownall, M. E., Tucker, A. S., Slack, J. M. W. and Isaacs, H. V (1996). eFGF,Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development 122, 3881-3892.[Abstract]
Richter, K., Grunz, H. and Dawid, I. B (1988). Gene expression in the embryonic nervous system of Xenopus laevis. Proc. Natl. Acad. Sci. USA 85, 8086-8090.[Abstract/Free Full Text]
Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J. C., Patient, R. and Holder, N (1999). Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGFfamily signals and discrimination of mesoderm and endoderm by FGF. Development 126, 3067-3078.[Abstract]
Ruiz i Altaba, A (1992). Planar and vertical signals in the induction and patterning of the Xenopus nervous system. Development 116, 67-80.[Abstract]
Ruiz i Altaba, A (1997). Catching a Gli-mpse of Hedgehog. Cell 90, 193-196.[Medline]
Ruiz i Altaba, A (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212.[Abstract]
Ruiz i Altaba, A (1999). Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216.[Abstract]
Ruiz i Altaba, A (1999). Gli proteins and Hedgehog signaling in development and cancer. Trends Genet 15, 418-425.[Medline]
Ruiz i Altaba, A. and Melton, D. A (1989). Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Cell 57, 317-326.[Medline]
Ruiz i Altaba, A. and Melton, D. A (1989). Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature 341, 33-38.[Medline]
Ruiz i Altaba, A., Choi, T. and Melton, D. A (1991). Expression of the Xhox3 homeobox protein in Xenopus embryos: blocking its early functionsuggests the requirement of Xhox3 for normal posterior development. Dev. Growth Differ 33, 651-669.
Ruiz i Altaba, A. and Jessell, T (1992). Pintallavis , a gene expressed in the organizer and midline cells in Xenopus. Involvement in the development of the neural axis. Development 116, 81-93.[Abstract]
Ruiz i Altaba, A., Jessell, T. M. and Roelink, H (1995). Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci 6, 106-121.[Medline]
Ryan, K., Butler, K., Bellefroid, E. and Gurdon, J. B (1998). Xenopus eomesodermin is expressed in neural differentiation. Mech. Dev 75, 155-158.[Medline]
Sampath, K., Cheng, A. M. S., Frisch, A. and Wright, C. V. E (1997). Functional differences among Xenopus nodal-related genes in left-right axis determination. Development 124, 3293-3302.[Abstract]
Sasaki, H., Hui, C., Nakafuku, M. and Kondoh, H (1997). A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.[Abstract]
Sasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M. and Kondoh, H (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3224.[Abstract]
Schulte-Merker, S. and Smith, J. C (1995). Mesoderm formation in response to Brachyury requires FGF signalling. Curr. Biol 5, 62-67.[Medline]
Shin, S. H., Kogerman, P., Lindstrom, E., Toftgard, R. and Biesecker, L. G (1999). Gli3 mutations in human disorders mimic Drosophila cubitus interruptus proteins functions and localizations. Proc. Natl. Acad. Sci. USA 96, 2880-2884.[Abstract/Free Full Text]
Smith, J. C., Price, B. M., Green, J. B., Weigel, D. and Herrmann, B (1991). Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79-87.[Medline]
Suzuki, A., Ueno, N. and Hemmati-Brivanlou, A (1997). Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. Development 124, 3037-3044.[Abstract]
Symes, K. and Smith, J. C. ( (1987). Gastrulation movements provide an early marker of mesoderm induction in Xenopus. Development 101, 339-349.[Abstract]
Takabatake, T., Ogawa, M., Takahashi, T. C., Mizuno, M., Okamoto, M. and Takeshima, K (1997). Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett 410, 485-489.[Medline]
Tada, M., O'Reilly, M.-A. J. and Smith, J. C (1997). Analysis of competence and of Brachyury autoinduction by use of hormone-inducible Xbra. Development 124, 2225-2234.[Abstract]
Turner, D. L. and Weintraub, H (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev 8, 1434-1447.[Abstract/Free Full Text]
Wallace, V. A (1999). Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr. Biol 9, 445-448.[Medline]
Wang, B., Fallon, J. F. and Beachy, P. A (2000). Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434.[Medline]
Wechsler-Reya, R. J. and Scott, M. P (1999). Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22, 103-114.[Medline]
Weinstein, D. C., Marden, J., Carnevali, F. and Hemmati-Brivanlou, A (1998). FGF-mediated mesoderm induction involves the Src-family kinase Laloo. Nature 394, 904-908.[Medline]
Yang, Y. and Niswander, L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]
Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M. A. and Rosenthal, A (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.[Medline]
