Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Tucker, A. S.
	Articles by Sharpe, P. T.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Tucker, A. S.
	Articles by Sharpe, P. T.


Social Bookmarking

	What's this?

Ashkenazi, A. and Dixit, V. M (1998). Death receptors: signaling and modulation. Science 281, 1305-1308.[Abstract/Free Full Text]

Bayes, M., Hartung, A. J., Ezer, S., Pispa, J., Thesleff, I., Srivastava, A. K. and Kere, J (1998). The anhidrotic ectodermal dsyplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Mol. Genet 7, 1661-1669.[Abstract/Free Full Text]

Butler, P. M (1956). The ontogeny of molar pattern. Biol. Rev 31, 30-70.

Chen, T. C., Hinton, D. R., Sippy, B. D. and Hofman, F. M (1997). Soluble TNF-alpha receptors are constitutively shed and downregulate adhesion molecule expression in malignant gliomas. J. Neuropathol. Exp. Neurol 56, 541-550.[Medline]

Crawford, P. J. M., Aldred, M. J. and Clarke, A (1991). Clinical and radiographic dental findings in X-linked hypohidrotic ectodermal dysplasia. J. Med. Genet 28, 181-185.[Abstract/Free Full Text]

Dassule, H. R. and McMahon, A. P (1998). Analysis of epithelial-mesenchmal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol 202, 215-227.[Medline]

Ezer, S., Sclessinger, D., Srivastava, A. K. and Kere, J (1997). Anhidotic ectodermal dysplasia (EDA) protein expressed in MCF-7 cells associates with cell membrane and induces rounding. Hum. Mol. Genet 6, 1581-1587.[Abstract/Free Full Text]

Falconer, D. S (1952). A totally sex-linked gene in the house mouse. Nature 169, 664-.[Medline]

Feinstein, E., Kimchi, A., Wallach, D., Boldin, M. and Varfolomeev, E (1995). The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem. Sci 20, 342-344.[Medline]

Ferguson, B. M., Brockdorff, N., Formstone, E., Ngyuen, T., Kronmiller, J. E. and Zonana, J (1997). Cloning of Tabby , the murine homologue of the human EDA gene: evidence for a membrane associated protein with a short collagenous domain. Hum. Mol. Genet 6, 1589-1594.[Abstract/Free Full Text]

Ferguson, B. M., Monreal, A., Headon, D., Overbeek, P. and Zonana, J (1998). An apparent new member of the TNF superfamily is encoded for by the EDA1 gene: evidence from mutation and two-hybrid analysis. Am. J. Hum. Genet 63, 52-.[Medline]

Giese, K., Cox, K. and Grosschedl, R (1992). The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 69, 185-195.[Medline]

Gruneberg, H (1965). Genes and genotypes affecting the teeth of the mouse. J.Embryol. Exp. Morphol 14, 137-159.[Medline]

Gruneberg, H (1966). The molars of the tabby mouse, and a test of the \324single activated X-chromosome' hypothesis. J. Embryol. Exp. Morphol 15, 223-244.[Medline]

Gruneberg, H (1971). The glandular aspect of the tabby syndrome in the mouse. J. Embryol. Exp. Morphol 25, 1-19.[Medline]

Headon, D. J. and Overbeek, P. A (1999). Involvement of a novel TNF receptor homolog in hair follicle development. Nat. Genet 22, 370-374.[Medline]

Hoschuetzky, H., Aberle, H. and Kemler, R (1994). \247-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol 127, 1375-1380.[Abstract/Free Full Text]

Jernvall, J., Kettunen, P., Karavanova, I., Martin, L. B. and Thesleff, I (1994). Evidence for the role of the enamel knot as a control centre in mammalian tooth cusp formation: non dividing cells express growth factor Fgf-4 gene. Int. J. Dev. Biol 38, 463-469.[Medline]

Jernvall, J., \201berg, T., Kettunen, P., Ker\212nen, S. and Thesleff, I (1998). The life history of an embryonic signalling center: BMP4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125, 161-169.[Abstract]

Kere, J., Srivasta, A. K., Montonen, O., Zonana, J., Thomas, N., Ferguson, B., Munoz, F., Morgan, D., Clarke, A., Baybayan, P., Chen, E. Y., Ezer, S., Saarialho-Kere, U., de la Chapelle, A. and Schlessinger, D (1996). X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by a mutation in a novel transmembrane protein. Nat. Genet 13, 409-416.[Medline]

Kratochwil, K., Dull, M., Farinas, I., Galceran, J. and Grosschedl, R (1996). Lef-1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev 10, 1382-1394.[Abstract/Free Full Text]

Mayer, T. C., Miller, C. K. and Green, M. C (1977). Site of action of the crinkled (cr) locus in the mouse. Dev. Biol 55, 397-401.[Medline]

Miard, S., Peterkova, R., Vonesch, J-L., Peterka., M., Ruch., J-V. and Lesot, H (1999). Alterations in the incisor development in the Tabby mouse. Int. J. Dev. Biol 43, 517-529.[Medline]

Micheau, O., Solary, E., Hammann, A. and Dimanche-Boitrel, M. T (1999). FasL independent, FADD-mediated activation of the Fas death pathway by anti-cancer drugs. J. Biol. Chem 274, 7987-7992.[Abstract/Free Full Text]

Mikkola, M. L., Pista, J., Pekkanen, M., Kere, J. and Thesleff, I (1998). Characterisation of the mouse Tabby protein, mutation of which causes ectodermal dysplasia. Mol. Biol. Cell 9, 1789-.

Mikkola, M. L., Pista, J., Pekkanen, M., Paulin, L., Nieminen, P., Kere, J. and Thesleff, I (1999). Ectodysplasin, a protein required for epithelial morphogensis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev 88, 133-146.[Medline]

Montonen, O., Ezer, S., Saarialho-Kere, U. K., Herva, R., Karjalainen-Linsberg, M., Kaitila, I., Sclessinger, D., Srivastava, A. K., Thesleff, I. and Kere, J (1998). The gene defective in anhidrotic ectodermal dysplasia is expressed in developing epithelium, neuroectoderm, thymus and bone. J. Histochem. Cytochem 46, 281-289.[Abstract/Free Full Text]

Monreal, A. W., Zonana, J. and Ferguson, B (1998). Identification of a new splice form of the EDA1 gene permits detection of nearly all X-linked hypohidrotic ectodermal dysplasia mutations. Am. J. Hum. Genet 63, 380-389.[Medline]

Monreal, A. W., Ferguson, B. M., Headon, D. J., Street, S. L., Overbeek, P. A. and Zonana, J (1999). Mutations in the human homolog of the mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Nat. Genet 22, 366-369.[Medline]

Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. C. and Strasser, A (1998). A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 17, 706-718.[Medline]

Pispa, J., Jung, H-S., Jernvall, J., Kettunen, P., Mustonen, T., Tabata, M. J., Kere, J. and Thesleff, I (1999). Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev. Biol 216, 521-534.[Medline]

Sarkar, L. and Sharpe, P. T (1999). Expression of Wnt signalling pathway genes during tooth development. Mech. Dev 85, 197-200.[Medline]

Saxen, L (1966). The effect of Tetracyclin on osteogenesis in vitro. J. Exp. Zool 162, 269-294.

Schneider, P., MacKay, F., Steiner,V., Hofmann, K., Bodmer, J. L., Holler,N., Ambrose, C., Lawton, P., Bixler, S., AchaOrbea, H. et al (1999). BAFF, a novel ligand of the TNF family stimulates B cell growth. J. Exp. Med 189, 1747-1756.[Abstract/Free Full Text]

Schneider, P (2000). Production of recombinant TRAIL and TRAIL receptors: Fc chimeric proteins. Meth. Enzymol 322, 325-345.[Medline]

Sofaer, J. A (1969). Aspects of the tabby-crinkled-downless syndrome I. The development of tabby teeth. J. Embryol. Exp. Morphol 22, 181-205.[Medline]

Sofaer, J. A (1969). Aspects of the tabby-crinkled-downless syndrome II. Observations on the reaction to changes of genetic background. J. Embryol. Exp. Morphol 22, 207-227.[Medline]

Sofaer, J. A (1977). Short communication: The teeth of the \324Sleek' mouse. Arch. Oral Biol 22, 299-301.[Medline]

Srivastava, A. K., Pispa, J., Hartung, A. J., Du, Y., Ezer, S., Jenks, T., Shimada, T., Pekkanen, M., Mikkola, M. L., Ko, M. S. H. et al (1997). The Tabby phenotype is caused by mutations in a mouse homoloue of the EDA gene that reveals novel mouse and human exons and encodes a proetin (ectodysplasin-A) with collagenous domains. Proc. Natl. Acad. Sci. USA 94, 13069-13074.[Abstract/Free Full Text]

Trowel, O. A (1959). The culture of mature organs in a synthetic medium. Exp. Cell Res 16, 118-147.[Medline]

Tucker, A. S., Al Khamis, A., Ferguson, C. A., Bach, I., Rosenfeld, M. G. and Sharpe, P. T (1999). Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126, 221-228.[Abstract]

Tucker, A. S. and Sharpe, P. T (1999). Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place. J. Dental Res 78, 826-834.[Abstract/Free Full Text]

Vaahtokari, A., \201berg., T. and Thesleff. I (1996). Apoptosis in the developing tooth: association with an embryonic signalling centre and suppression by EGF and FGF-4. Development 122, 121-129.[Abstract]

Vaahtokari, A., \201berg., T., Jernvall, J., Ker\212nen, S. and Thesleff. I (1996). The enamel knot as a signalling centre in the developing mouse tooth. Mech. Dev 54, 39-43.[Medline]

van Genderen, C., Okamura, R. M., Farinas, I., Quo, R., Parslow, T. G., Bruhn, L. and Grosschedl, R (1994). Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1 deficient mice. Genes Dev 8, 2691-2703.[Abstract/Free Full Text]

Zhou, P., Byrne, C., Jacobs, J. and Fuchs, E (1995). Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev 9, 700-713.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

S. J. Mathew, D. Haubert, M. Kronke, and M. Leptin
Looking beyond death: a morphogenetic role for the TNF signalling pathway
J. Cell Sci., June 15, 2009; 122(12): 1939 - 1946.
[Abstract] [Full Text] [PDF]

M. Pummila, I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff, and M. L. Mikkola
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
Development, January 1, 2007; 134(1): 117 - 125.
[Abstract] [Full Text] [PDF]

J. Laurikkala, M. L. Mikkola, M. James, M. Tummers, A. A. Mills, and I. Thesleff
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
Development, April 15, 2006; 133(8): 1553 - 1563.
[Abstract] [Full Text] [PDF]

T. Boran, H. Lesot, M. Peterka, and R. Peterkova
Increased Apoptosis during Morphogenesis of the Lower Cheek Teeth in Tabby/EDA Mice
Journal of Dental Research, March 1, 2005; 84(3): 228 - 233.
[Abstract] [Full Text] [PDF]

M. L. Chaisson, D. G. Branstetter, J. M. Derry, A. P. Armstrong, M. E. Tometsko, K. Takeda, S. Akira, and W. C. Dougall
Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of {kappa}B Kinase {alpha}
J. Biol. Chem., December 24, 2004; 279(52): 54841 - 54848.
[Abstract] [Full Text] [PDF]

T. Mustonen, M. Ilmonen, M. Pummila, A. T. Kangas, J. Laurikkala, R. Jaatinen, J. Pispa, O. Gaide, P. Schneider, I. Thesleff, et al.
Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
Development, October 15, 2004; 131(20): 4907 - 4919.
[Abstract] [Full Text] [PDF]

A. Ohazama, J.-M. Courtney, and P.T. Sharpe
Opg, Rank, and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis
Journal of Dental Research, March 1, 2004; 83(3): 241 - 244.
[Abstract] [Full Text] [PDF]

E. Matalova, A.S. Tucker, and P.T. Sharpe
Death in the Life of a Tooth
Journal of Dental Research, January 1, 2004; 83(1): 11 - 16.
[Abstract] [Full Text] [PDF]

I. Miletich and P. T. Sharpe
Normal and abnormal dental development
Hum. Mol. Genet., April 2, 2003; 12(90001): R69 - 73.
[Abstract] [Full Text] [PDF]

J. Laurikkala, J. Pispa, H.-S. Jung, P. Nieminen, M. Mikkola, X. Wang, U. Saarialho-Kere, J. Galceran, R. Grosschedl, and I. Thesleff
Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
Development, March 7, 2003; 129(10): 2541 - 2553.
[Abstract] [Full Text] [PDF]

N. Holler, A. Tardivel, M. Kovacsovics-Bankowski, S. Hertig, O. Gaide, F. Martinon, A. Tinel, D. Deperthes, S. Calderara, T. Schulthess, et al.
Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex
Mol. Cell. Biol., February 15, 2003; 23(4): 1428 - 1440.
[Abstract] [Full Text] [PDF]

K. Kratochwil, J. Galceran, S. Tontsch, W. Roth, and R. Grosschedl
FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1-/- mice
Genes & Dev., December 15, 2002; 16(24): 3173 - 3185.
[Abstract] [Full Text] [PDF]

C.-Y. Cui, M. Durmowicz, T. S. Tanaka, A. J. Hartung, T. Tezuka, K. Hashimoto, M. S.H. Ko, A. K. Srivastava, and D. Schlessinger
EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice
Hum. Mol. Genet., July 15, 2002; 11(15): 1763 - 1773.
[Abstract] [Full Text] [PDF]

S. Lisi, R. Peterkova, P. Kristenova, J.L. Vonesch, M. Peterka, and H. Lesot
Crown Morphology and Pattern of Odontoblast Differentiation in Lower Molars of Tabby Mice
Journal of Dental Research, November 1, 2001; 80(11): 1980 - 1983.
[Abstract] [PDF]

V. A. BOTCHKAREV, N. V. BOTCHKAREVA, M. NAKAMURA, O. HUBER, K. FUNA, R. LAUSTER, R. PAUS, and B. A. GILCHREST
Noggin is required for induction of the hair follicle growth phase in postnatal skin
FASEB J, October 1, 2001; 15(12): 2205 - 2214.
[Abstract] [Full Text] [PDF]

H. Lesot, S. Lisi, R. Peterkova, M. Peterka, V. Mitolo, and J.V. Ruch
Epigenetic Signals during Odontoblast Differentiation
Advances in Dental Research, August 1, 2001; 15(1): 8 - 13.
[Abstract] [PDF]

Y. Chen, S. S. Molloy, L. Thomas, J. Gambee, H. P. Bachinger, B. Ferguson, J. Zonana, G. Thomas, and N. P. Morris
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia
PNAS, June 19, 2001; 98(13): 7218 - 7223.
[Abstract] [Full Text] [PDF]

O. Elomaa, K. Pulkkinen, U. Hannelius, M. Mikkola, U. Saarialho-Kere, and J. Kere
Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein
Hum. Mol. Genet., April 1, 2001; 10(9): 953 - 962.
[Abstract] [Full Text] [PDF]

P. Schneider, S. L. Street, O. Gaide, S. Hertig, A. Tardivel, J. Tschopp, L. Runkel, K. Alevizopoulos, B. M. Ferguson, and J. Zonana
Mutations Leading to X-linked Hypohidrotic Ectodermal Dysplasia Affect Three Major Functional Domains in the Tumor Necrosis Factor Family Member Ectodysplasin-A
J. Biol. Chem., May 25, 2001; 276(22): 18819 - 18827.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Tucker, A. S.

Articles by Sharpe, P. T.

Search for Related Content

PubMed

PubMed Citation

Articles by Tucker, A. S.

Articles by Sharpe, P. T.

Social Bookmarking

What's this?

				M. Pummila, I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff, and M. L. Mikkola Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression Development, January 1, 2007; 134(1): 117 - 125. [Abstract] [Full Text] [PDF]

				J. Laurikkala, M. L. Mikkola, M. James, M. Tummers, A. A. Mills, and I. Thesleff p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation Development, April 15, 2006; 133(8): 1553 - 1563. [Abstract] [Full Text] [PDF]

				T. Boran, H. Lesot, M. Peterka, and R. Peterkova Increased Apoptosis during Morphogenesis of the Lower Cheek Teeth in Tabby/EDA Mice Journal of Dental Research, March 1, 2005; 84(3): 228 - 233. [Abstract] [Full Text] [PDF]

				M. L. Chaisson, D. G. Branstetter, J. M. Derry, A. P. Armstrong, M. E. Tometsko, K. Takeda, S. Akira, and W. C. Dougall Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of {kappa}B Kinase {alpha} J. Biol. Chem., December 24, 2004; 279(52): 54841 - 54848. [Abstract] [Full Text] [PDF]

				T. Mustonen, M. Ilmonen, M. Pummila, A. T. Kangas, J. Laurikkala, R. Jaatinen, J. Pispa, O. Gaide, P. Schneider, I. Thesleff, et al. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages Development, October 15, 2004; 131(20): 4907 - 4919. [Abstract] [Full Text] [PDF]

				A. Ohazama, J.-M. Courtney, and P.T. Sharpe Opg, Rank, and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis Journal of Dental Research, March 1, 2004; 83(3): 241 - 244. [Abstract] [Full Text] [PDF]

				E. Matalova, A.S. Tucker, and P.T. Sharpe Death in the Life of a Tooth Journal of Dental Research, January 1, 2004; 83(1): 11 - 16. [Abstract] [Full Text] [PDF]

				I. Miletich and P. T. Sharpe Normal and abnormal dental development Hum. Mol. Genet., April 2, 2003; 12(90001): R69 - 73. [Abstract] [Full Text] [PDF]

				J. Laurikkala, J. Pispa, H.-S. Jung, P. Nieminen, M. Mikkola, X. Wang, U. Saarialho-Kere, J. Galceran, R. Grosschedl, and I. Thesleff Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar Development, March 7, 2003; 129(10): 2541 - 2553. [Abstract] [Full Text] [PDF]

				N. Holler, A. Tardivel, M. Kovacsovics-Bankowski, S. Hertig, O. Gaide, F. Martinon, A. Tinel, D. Deperthes, S. Calderara, T. Schulthess, et al. Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex Mol. Cell. Biol., February 15, 2003; 23(4): 1428 - 1440. [Abstract] [Full Text] [PDF]

				K. Kratochwil, J. Galceran, S. Tontsch, W. Roth, and R. Grosschedl FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1-/- mice Genes & Dev., December 15, 2002; 16(24): 3173 - 3185. [Abstract] [Full Text] [PDF]

				C.-Y. Cui, M. Durmowicz, T. S. Tanaka, A. J. Hartung, T. Tezuka, K. Hashimoto, M. S.H. Ko, A. K. Srivastava, and D. Schlessinger EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice Hum. Mol. Genet., July 15, 2002; 11(15): 1763 - 1773. [Abstract] [Full Text] [PDF]

				S. Lisi, R. Peterkova, P. Kristenova, J.L. Vonesch, M. Peterka, and H. Lesot Crown Morphology and Pattern of Odontoblast Differentiation in Lower Molars of Tabby Mice Journal of Dental Research, November 1, 2001; 80(11): 1980 - 1983. [Abstract] [PDF]

				V. A. BOTCHKAREV, N. V. BOTCHKAREVA, M. NAKAMURA, O. HUBER, K. FUNA, R. LAUSTER, R. PAUS, and B. A. GILCHREST Noggin is required for induction of the hair follicle growth phase in postnatal skin FASEB J, October 1, 2001; 15(12): 2205 - 2214. [Abstract] [Full Text] [PDF]

				H. Lesot, S. Lisi, R. Peterkova, M. Peterka, V. Mitolo, and J.V. Ruch Epigenetic Signals during Odontoblast Differentiation Advances in Dental Research, August 1, 2001; 15(1): 8 - 13. [Abstract] [PDF]

				Y. Chen, S. S. Molloy, L. Thomas, J. Gambee, H. P. Bachinger, B. Ferguson, J. Zonana, G. Thomas, and N. P. Morris Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia PNAS, June 19, 2001; 98(13): 7218 - 7223. [Abstract] [Full Text] [PDF]

				O. Elomaa, K. Pulkkinen, U. Hannelius, M. Mikkola, U. Saarialho-Kere, and J. Kere Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein Hum. Mol. Genet., April 1, 2001; 10(9): 953 - 962. [Abstract] [Full Text] [PDF]

				P. Schneider, S. L. Street, O. Gaide, S. Hertig, A. Tardivel, J. Tschopp, L. Runkel, K. Alevizopoulos, B. M. Ferguson, and J. Zonana Mutations Leading to X-linked Hypohidrotic Ectodermal Dysplasia Affect Three Major Functional Domains in the Tumor Necrosis Factor Family Member Ectodysplasin-A J. Biol. Chem., May 25, 2001; 276(22): 18819 - 18827. [Abstract] [Full Text] [PDF]