Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, T. and Edlund, H (1997). Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385, 257-260.[Medline]
Apelqvist, A., Ahlgren, U. and Edlund, H (1997). Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol 7, 801-804.[Medline]
Belloni, E., Muenke, M., Roessler, E., Traverso, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C., Hing, A. V. et al (1996). Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat. Genet 14, 353-356.[Medline]
Bitgood, M. J. and McMahon, A. P (1995). Hedgehog and BMP genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol 172, 126-138.[Medline]
Bonner-Weir, S., Deery, D., Leahy, J. L. and Weir, G.C (1989). : Compensatory growth of pancreatic-cells in adult rats after short-term infusion. Diabetes 38, 49-53.[Abstract]
Bruning, J. C., Winnay, J., Bonner-Weir, S., Taylor, S. I., Accili, D. andKahn, C. R (1997). Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561-572.[Medline]
Carpenter, D.,Stone, D. M., Brush, J., Ryan, A., Armanini, M., Frantz, G., Rosenthal, A. and de Sauvage, F. J (1998). Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. USA 95, 13630-13634.[Abstract/Free Full Text]
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking sonic hedgehog function. Nature 383, 407-413.[Medline]
Chuang, P. T. and McMahon, A. P (1999). Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397, 617-621.[Medline]
Cooper, M. K., Porter, J. A., Young, K. E. and Beachy, P. A (1998). Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280, 1603-1607.[Abstract/Free Full Text]
Duprez, D., Fournier-Thibault, C. and Le Douarin, N (1998). SonicHedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development 125, 495-505.[Abstract]
Duprez, D., Lapointe, F., Edom-Vovard, F., Kostakopoulou, K. and Robson, L (1999). Sonic hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud. Mech. Dev 82, 151-163.[Medline]
Ericson, J., Briscoe, J., Rashbass, P., van Heyningen, V. and Jessell, T. M (1997). Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harb. Symp. Quant. Biol 62, 451-466.[Abstract/Free Full Text]
Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M. and Edlund, T (1995). Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.[Medline]
Fan, C. M. and Tessier-Lavigne, M (1994). Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79, 1175-1186.[Medline]
Gittes, G. K. and Rutter, W. J (1992). Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. USA 89, 1128-1132.[Abstract/Free Full Text]
Goodrich, L. V., Jung, D., Higgins, K. M. and Scott, M. P (1999). Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev. Biol 211, 323-334.[Medline]
Goodrich, L. V., Milenkovic, L., Higgins, K. M. and Scott, M. P (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113.[Abstract/Free Full Text]
Gross, R. E. and Chisholm, T. C (1944). Annular pancreas producing duodenal obstruction. Ann. Surg 119, 759-769.[Medline]
Hahn, H., Wicking, C., Zaphiropoulous, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S. et al (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851.[Medline]
Hammerschmidt, M., Brook, A. and McMahon, A. P (1997). The world according to hedgehog. Trends. Genet 13, 14-21.[Medline]
Hebrok, M., Kim, S. K. and Melton, D. A (1998). Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 12, 1705-1713.[Abstract/Free Full Text]
Jensen, A. M. and Wallace, V. A (1997). Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development 124, 363-371.[Abstract]
Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., Jr and Scott, M. P (1996). Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671.[Abstract]
Kallen, B., Mastroiacovo, P. and Robert, E (1996). Major congenital malformations in Down syndrome. Am. J. Med. Genet 65, 160-166.[Medline]
Karp, S. J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H.and McMahon, A. P (2000). Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and-independent pathways. Development 127, 543-548.[Abstract]
Kelley, R. L., Roessler, E., Hennekam, R. C., Feldman, G. L., Kosaki, K., Jones, M. C., Palumbos, J. C. and Muenke, M (1996). Holoprosencephaly in RSH/Smith-Lemli-Opitz syndrome: does abnormal cholesterol metabolism affect the function of Sonic Hedgehog?. Am. J. Med. Genet 66, 478-484.[Medline]
Kiernan, P. D., ReMine, S. G., Kiernan, P. C. and ReMine, W. H (1980). Annular pancreas: May clinic experience from 1957 to 1976 with review of the literature. Arch. Surg 115, 46-50.[Abstract]
Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H. and Melton, D. A (2000). Activin receptor patterning of foregut organogenesis. Genes Dev 14, 1866-1871.[Abstract/Free Full Text]
Kim, S. K., Hebrok, M. and Melton, D. A (1997). Notochord to endoderm signaling is required for pancreas development. Development 124, 4243-4252.[Abstract]
Kim, S. K. and Melton, D. A (1998). Pancreas development is promoted bycyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA 95, 13036-13041.[Abstract/Free Full Text]
Lachman, M. F., Wright, Y., Whiteman, D. A., Herson, V. and Greenstein, R. M (1991). Brief clinical report: a 46,XY phenotypic female with Smith-Lemli-Opitz syndrome. Clin. Genet 39, 136-141.[Medline]
Levine, E. M., Roelink, H., Turner, J. and Reh, T. A (1997). Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. J. Neurosci 17, 6277-6288.[Abstract/Free Full Text]
Levy, J (1991). The gastrointestinal tract in Down syndrome. Prog Clin. Biol. Res 373, 245-256.[Medline]
Litingtung, Y., Lei, L., Westphal, H. and Chiang, C (1998). Sonic hedgehog is essential to foregut development. Nat. Genet 20, 58-61.[Medline]
McKeever, P. A. and Young, I. D (1990). Smith-Lemli-Opitz syndrome. II: A disorder of the fetal adrenals?. J. Med. Genet 27, 465-466.[Abstract/Free Full Text]
Miao, N., Wang, M., Ott, J. A., D'Alessandro, J. S., Woolf, T. M., Bumcrot, D. A., Mahanthappa, N. K. and Pang, K (1997). Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro. J. Neurosci 17, 5891-5899.[Abstract/Free Full Text]
Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M. and Hui, C. C (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet 20, 54-57.[Medline]
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R., Magnuson, M. A., Hogan, B. L. M. and Wright, C. V. E (1996). PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983-995.[Abstract]
Pepicelli, C. V., Lewis, P. M. and McMahon, A. P (1998). Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol 8, 1083-1086.[Medline]
Ramalho-Santos, M., Melton, D. A., McMahon, A. P (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772.[Abstract]
Roberts, D. J., Johnson, R. L., Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C (1995). Sonic hedgehog is an endodermal signal inducing BMP-4 and Hox genes during induction and regionalization of the chick hindgut. Development 121, 3163-3174.[Abstract]
Slack, J. M. W (1995). Developmental biology of the pancreas. Development 121, 1569-1580.[Abstract]
St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R. and McMahon, A. P (1998). Sonic hedgehog signaling is essential for hair development. Curr. Biol 8, 1058-1068.[Medline]
St-Jacques, B., Hammerschmidt, M. and McMahon, A. P (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13, 2072-2086.[Abstract/Free Full Text]
Treier, M., Gleiberman, A. S., O'Connell, S. M., Szeto, D. P., McMahon, J. A., McMahon, A. P. and Rosenfeld, M. G (1998). Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 12, 1691-1704.[Abstract/Free Full Text]
Wilson, P. and Melton, D. A (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol 4, 676-686.[Medline]
Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J., Niswander, L., McMahon, A. and Tickle, C (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404.[Abstract]