The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus

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Bisgrove, B. W., Essner, J. J. and Yost, H. J (1999). Regulation of midline development by antagonism of lefty and nodal signaling. Development 126, 3253-3262.[Abstract]

Boettger, T., Wittler, L. and Kessel, M (1999). FGF8 functions in the specification of the right body side of the chick. Curr. Biol 9, 277-280.[Medline]

Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E. M (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.[Medline]

Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., van Bebber, F., Lowe, L. A., Nowotschin, S., Viebahn, C., Haffter, P., Kuehn, M. R. et al (1999). The homeobox gene Pitx2 : mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development 126, 1225-1234.[Abstract]

Chang, C., Wilson, P. A., Mathews, L. S. and Hemmati-Brivanlou, A (1997). A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. Development 124, 827-837.[Abstract]

Chazaud, C., Chambon, P. and Dolle, P (1999). Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 126, 2589-2596.[Abstract]

Collignon, J., Varlet, I. and Robertson, E. J (1996). Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155-158.[Medline]

Condie, B. G., Brivanlou, A. H. and Harland, R. M (1990). Most of the homeobox-containing Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein. Mol. Cell Biol 10, 3376-3385.[Abstract/Free Full Text]

Drysdale, T. A., Tonissen, K. F., Patterson, K. D., Crawford, M. J. and Krieg, P. A (1994). Cardiac troponin I is a heart-specific marker in the Xenopus embryo: expression during abnormal heart morphogenesis. Dev. Biol 165, 432-441.[Medline]

Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J. and Melton, D. A (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.[Medline]

Gritsman, K., Zhang, J., Cheng, S., Heckscher, E., Talbot, W. S. and Schier, A. F (1999). The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell 97, 121-132.[Medline]

Harland, R. M (1991). In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol 36, 685-695.[Medline]

Harvey, R. P (1998). Links in the left/right axial pathway. Cell 94, 273-276.[Medline]

Hyatt, B. A. and Yost, H. J (1998). The left-right coordinator: the role of Vg1 in organizing left-right axis formation. Cell 93, 37-46.[Medline]

Johnson, A. D. and Krieg, P. A (1994). pXeX, a vector for efficient expression of cloned sequences in Xenopus embryos. Gene 147, 223-226.[Medline]

Jones, C. M., Kuehn, M. R., Hogan, B. L., Smith, J. C. and Wright, C. V (1995). Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 3651-3662.[Abstract]

Joseph, E. M. and Melton, D. A (1997). Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer. Dev. Biol 184, 367-372.[Medline]

Kingsley, D. M (1994). The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8, 133-146.[Free Full Text]

Krieg, P. A., Varnum, S. M., Wormington, W. M. and Melton, D. A (1989). The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus. Dev. Biol 133, 93-100.[Medline]

Lemaire, P. and Gurdon, J. B (1994). A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos. Development 120, 1191-1199.[Abstract]

Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M. and Tabin, C (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.[Medline]

Lin, C. R., Kioussi, C., O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisua-Belmonte, J. C. and Rosenfeld, M. G (1999). Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401, 279-282.[Medline]

Logan, M., Pagan-Westphal, S. M., Smith, D. M., Paganessi, L. and Tabin, C. J (1998). The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 94, 307-317.[Medline]

Lowe, L. A., Supp, D. M., Sampath, K., Yokoyama, T., Wright, C. V., Potter, S. S., Overbeek, P. and Kuehn, M. R (1996). Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381, 158-161.[Medline]

Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J (1999). Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298.

Meno, C., Saijoh, Y., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y. and Hamada, H (1996). Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature 381, 151-155.[Medline]

Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H. and Hamada, H (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.[Medline]

Meyers, E. N. and Martin, G. R (1999). Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285, 403-406.[Abstract/Free Full Text]

Mochizuki, T., Saijoh, Y., Tsuchiya, K., Shirayoshi, Y., Takai, S., Taya, C., Yonekawa, H., Yamada, K., Nihei, H., Nakatsuji, N (1998). Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature 395, 177-181.[Medline]

Narita, N., Bielinska, M. and Wilson, D. B (1997). Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development 124, 3755-3764.[Abstract]

Nascone, N. and Mercola, M (1995). An inductive role for the endoderm in Xenopus cardiogenesis. Development 121, 515-523.[Abstract]

Osada, S. I. and Wright, C. V (1999). Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development 126, 3229-3240.[Abstract]

Patel, K., Isaac, A. and Cooke, J (1999). Nodal signalling and the roles of the transcription factors SnR and pitx2 in vertebrate left-right asymmetry. Curr. Biol 9, 609-612.[Medline]

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E. M (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.[Medline]

Piedra, M. E., Icardo, J. M., Albajar, M., Rodriguez-Rey, J. C. and Ros, M. A (1998). Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 94, 319-324.[Medline]

Rodriguez Esteban, C., Capdevila, J., Economides, A. N., Pascual, J., Ortiz, A. and Izpisua Belmonte, J. C (1999). The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature 401, 243-251.[Medline]

Ryan, A. K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Pena, J., Sabbagh, W., Greenwald, J., Choe, S (1998). Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-551.[Medline]

Saijoh, Y., Adachi, H., Sakuma, R., Yeol-yeo, C., Watanabe, M., Hashiguchi, H., Mochida, K., Ohishi, S., Kawabata, M., Miyazono, K. et al (2000). Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell 5, 35-47.

Sampath, K., Cheng, A. M., Frisch, A. and Wright, C. V (1997). Functional differences among Xenopus nodal-related genes in left-right axis determination. Development 124, 3293-3302.[Abstract]

Sasai, Y., Lu, B., Piccolo, S. and De Robertis, E. M (1996). Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J 15, 4547-4555.[Medline]

Sasai, Y., Lu, B., Steinbeisser, H. and De Robertis, E. M (1995). Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376, 333-336.[Medline]

Schneider, A., Mijalski, T., Schlange, T., Dai, W., Overbeek, P., Arnold, H. H. and Brand, T (1999). The homeobox gene it NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr. Biol 9, 911-914.[Medline]

Shen, M. M., Wang, H. and Leder, P (1997). A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development 124, 429-442.[Abstract]

Smith, W. C., McKendry, R., Ribisi, S., Jr. and Harland, R. M (1995). Anodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82, 37-46.[Medline]

Sun, B. I., Bush, S. M., Collins-Racie, L. A., LaVallie, E. R., DiBlasio-Smith, E. A., Wolfman, N. M., McCoy, J. M. and Sive, H. L (1999). derriere: a TGF-family member required for posterior development in Xenopus. Development 126, 1467-1482.[Abstract]

Supp, D. M., Witte, D. P., Potter, S. S. and Brueckner, M (1997). Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature 389, 963-966.[Medline]

Thisse, C. and Thisse, B (1999). Antivin, a novel and divergent member of the TGFsuperfamily, negatively regulates mesoderm induction. Development 126, 229-240.[Abstract]

Wilson, P. A. and Melton, D. A (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol 4, 676-686.[Medline]

Yokouchi, Y., Vogan, K. J., Pearse, R. V., 2nd and Tabin, C. J (1999). Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Cell 98, 573-583.[Medline]

Yoshioka, H., Meno, C., Koshiba, K., Sugihara, M., Itoh, H., Ishimaru, Y., Inoue, T., Ohuchi, H., Semina, E. V., Murray, J. C. et al (1998). Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94, 299-305.[Medline]

Yost, H. J (1998). The genetics of midline and cardiac laterality defects. Curr. Opin. Cardiol 13, 185-189.[Medline]

Zhou, X., Sasaki, H., Lowe, L., Hogan, B. L. and Kuehn, M. R (1993). Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature 361, 543-547.[Medline]

Zhu, L., Marvin, M. J., Gardiner, A., Lassar, A. B., Mercola, M., Stern, C. D. and Levin, M (1999). Cerberus regulates left-right asymmetry of the embryonic head and heart. Curr. Biol 9, 931-938.[Medline]

Zorn, A. M., Butler, K. and Gurdon, J. B (1999). Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev. Biol 209, 282-297.[Medline]

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				L. Ulloa and S. Tabibzadeh Lefty Inhibits Receptor-regulated Smad Phosphorylation Induced by the Activated Transforming Growth Factor-beta Receptor J. Biol. Chem., June 8, 2001; 276(24): 21397 - 21404. [Abstract] [Full Text] [PDF]