Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract

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Abdelhak, S., Kalatzis, V., Heilig, R., Compain, S., Samson, D., Vincent, C., Weil, D., Cruaud, C., Sahly, I., Leibovici, M (1997). A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat. Genet 15, 157-164.[Medline]

Barnes, J. D., Crosby, J. L., Jones, C. M., Wright, C. V. and Hogan, B. L. M (1994). Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol 161, 168-178.[Medline]

Chen, J., Knowles, H. J., Hebert, J. L. and Hackett, B. P (1998). Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest 102, 1077-1082.[Medline]

Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G. and Whitman, M (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89.[Medline]

Green, M. C (1970). The developmental effects of congenital hydrocephalus (ch) in the mouse. Dev. Biol 23, 585-608.[Medline]

Gruneberg, H (1943). Congenital hydrocephalus in the mouse: a case of spurious pleiotropism. J. Genet 45, 1-21.

Gruneberg, H (1953). Genetical studies on the skeleton of the mouse VII. Congenital hydrocephalus. J. Genet 51, 327-358.

Hatini, V., Huh, S. O., Herzlinger, D., Soares, V. C. and Lai, E (1996). Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev 10, 1467-1478.[Abstract/Free Full Text]

Hiemisch, H., Monaghan, A. P., Schutz, G. and Kaestner, K. H (1998). Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives. Mech. Dev 73, 129-132.[Medline]

Hong, H. K., Lass, J. H. and Chakravarti, A (1999). Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene. Hum. Mol. Genet 8, 625-637.[Abstract/Free Full Text]

Iida, K., Koseki, H., Kakinuma, H., Kato, N., Mizutani-Koseki, Y., Ohuchi, H., Yoshioka, H., Noji, S., Kawamura, K., Kataoka, Y., Ueno F., Taniguchi M., Yoshida N., Sugiyama T., and Miura N (1997). Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124, 4627-4638.[Abstract]

Kaestner, K. H., Bleckmann, S. C., Monaghan, A. P., Schlondorff, J., Mincheva, A., Lichter, P. and Schutz, G (1996). Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development 122, 1751-1758.[Abstract]

Kaestner, K. H., Silberg, D. G., Traber, P. G. and Schutz, G (1997). The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev 11, 1583-1595.[Abstract/Free Full Text]

Kaestner, K. H., Knochel, W. and Martinez, D. E (2000). Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 14, 142-146.[Free Full Text]

Kaufmann, E. and Knochel, W (1996). Five years on the wings of fork head. Mech. Dev 57, 3-20.[Medline]

Kidson, S. H., Kume, T., Deng, K., Winfrey, V. and Hogan, B. L. M (1999). The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev. Biol 211, 306-322.[Medline]

Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L. and Burgering, B. M (1999). Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634.[Medline]

Kume, T., Deng, K. Y., Winfrey, V., Gould, D. B., Walter, M. A. and Hogan, B. L. M (1998). The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell 93, 985-996.[Medline]

Kume, T., Deng, K. and Hogan, B. L. M (2000). Minimal phenotype of micehomozygous for a null mutation in the forkhead/winged helix gene, Mf2. Mol. Cell Biol 20, 1419-1425.[Abstract/Free Full Text]

Labbe, E., Silvestri, C., Hoodless, P. A., Wrana, J. L. and Attisano, L (1998). Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Molec. Cell 2, 109-120.

Labosky, P. A., Winnier, G. E., Jetton, T. L., Hargett, L., Ryan, A. K., Rosenfeld, M. G., Parlow, A. F. and Hogan, B. L. M (1997). The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development 124, 1263-1274.[Abstract]

Lin, K., Dorman, J. B., Rodan, A. and Kenyon, C (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.[Abstract/Free Full Text]

Mackie, G. G. and Stephens, F. D (1975). Duplex kidneys: a correlation of renal dysplasia with position of the ureteral orifice. J. Urol 114, 274-280.[Medline]

Miura, N., Wanaka, A., Tohyama, M. and Tanaka, K (1993). MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett 326, 171-176.[Medline]

Moore, M. W., Klein, R. D., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L. F., Ryan, A. M., Carver-Moore, K. and Rosenthal, A (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76-79.[Medline]

Nishimura, H., Yerkes, E., Hohenfellner, K., Miyazaki, Y., Ma, J., Hunley, T. E., Yoshida, H., Ichiki, T., Threadgill, D., Phillips, J. A. 3rd., Hogan, B. L. M., Fogo, A., Brock, J. W. 3rd., Inagami, T., and Ichikawa, I (1999). Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol. Cell 3, 1-10.

Overdier, D. G., Ye, H., Peterson, R. S., Clevidence, D. E. and Costa, R. H (1997). The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. J. Biol. Chem 272, 13725-13730.[Abstract/Free Full Text]

Pachnis, V., Mankoo, B. and Costantini, F (1993). Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119, 1005-1017.[Abstract]

Pelletier, G. J., Brody, S. L., Liapis, H., White, R. A. and Hackett, B. P (1998). A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am J. Physiol 274, 351-359.

Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A. C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., Sariola H., and Westphal H (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382, 73-76.[Medline]

Pope, J. C. 4th, Brock, J. W., 3rd, Adams, M. C., Stephens, F. D. and Ichikawa, I (1999). How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT. J. Am. Soc. Nephrol 10, 2018-2028.[Free Full Text]

Rosenthal, A (1999). The GDNF protein family: gene ablation studies reveal what they really do and how. Neuron 22, 201-203.[Medline]

Sainio, K. and Raatikainen-Ahokas, A (1999). Mesonephric kidney\320a stem cell factory?. Int. J. Dev. Biol 43, 435-439.[Medline]

Sainio, K., Suvanto, P., Davies, J., Wartiovaara, J., Wartiovaara, K., Saarma, M., Arumae, U., Meng, X., Lindahl, M., Pachnis, V (1997). Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 124, 4077-4087.[Abstract]

Sanchez, M. P., Silos-Santiago, I., Frisen, J., He, B., Lira, S. A. and Barbacid, M (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70-73.[Medline]

Sariola, H. and Sainio, K (1997). The tip-top branching ureter. Curr. Opin. Cell Biol 9, 877-884.[Medline]

Schuchardt, A., D'Agati, V., Pachnis, V. and Costantini, F (1996). Renal agenesis and hypodysplasia in ret-k-mutant mice result from defects in ureteric bud development. Development 122, 1919-1929.[Abstract]

Swiderski, R. E., Reiter, R. S., Nishimura, D. Y., Alward, W. L., Kalenak, J. W., Searby, C. S., Stone, E. M., Sheffield, V. C. and Lin, J. J (1999). Expression of the Mf1 gene in developing mouse hearts: Implication in the development of human congenital heart defects. Dev. Dyn 216, 16-27.[Medline]

Winnier, G. E., Hargett, L. and Hogan, B. L. M (1997). The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev 11, 926-940.[Abstract/Free Full Text]

Winnier, G. E., Kume, T., Deng, K., Rogers, R., Bundy, J., Raines, C., Walter, M. A., Hogan, B. L. M. and Conway, S. J (1999). Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev. Biol 213, 418-431.[Medline]

Xu, P. X., Adams, J., Peters, H., Brown, M. C., Heaney, S. and Maas, R (1999). Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet 23, 113-117.[Medline]

Xuan, S., Baptista, C. A., Balas, G., Tao, W., Soares, V. C. and Lai, E (1995). Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14, 1141-1152.[Medline]

Zhou, S., Zawel, L., Lengauer, C., Kinzler, K. W. and Vogelstein, B (1998). Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol. Cell 2, 121-127.

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				J. M. Skarie and B. A. Link FoxC1 Is Essential for Vascular Basement Membrane Integrity and Hyaloid Vessel Morphogenesis Invest. Ophthalmol. Vis. Sci., November 1, 2009; 50(11): 5026 - 5034. [Abstract] [Full Text] [PDF]

				Z. Saifudeen, S. Dipp, J. Stefkova, X. Yao, S. Lookabaugh, and S. S. El-Dahr p53 Regulates Metanephric Development J. Am. Soc. Nephrol., November 1, 2009; 20(11): 2328 - 2337. [Abstract] [Full Text] [PDF]

				E. J. Rozen, H. Schmidt, X. Dolcet, M. A. Basson, S. Jain, and M. Encinas Loss of Sprouty1 Rescues Renal Agenesis Caused by Ret Mutation J. Am. Soc. Nephrol., February 1, 2009; 20(2): 255 - 259. [Abstract] [Full Text] [PDF]

				G. Williams, J. T. Fletcher, S. I. Alexander, and J. C. Craig Vesicoureteral Reflux J. Am. Soc. Nephrol., May 1, 2008; 19(5): 847 - 862. [Abstract] [Full Text] [PDF]

				F. B. Berry, J. M. Skarie, F. Mirzayans, Y. Fortin, T. J. Hudson, V. Raymond, B. A. Link, and M. A. Walter FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A Hum. Mol. Genet., February 14, 2008; 17(4): 490 - 505. [Abstract] [Full Text] [PDF]

				T. Hoshino, R. Shimizu, S. Ohmori, M. Nagano, X. Pan, O. Ohneda, M. Khandekar, M. Yamamoto, K.-C. Lim, and J. D. Engel Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells, February 1, 2008; 13(2): 159 - 170. [Abstract] [Full Text] [PDF]

				I. J. Murawski, D. B. Myburgh, J. Favor, and I. R. Gupta Vesico-ureteric reflux and urinary tract development in the Pax21Neu+/ mouse Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1736 - F1745. [Abstract] [Full Text] [PDF]

				R. Viana, E. Batourina, H. Huang, G. R. Dressler, A. Kobayashi, R. R. Behringer, E. Shapiro, T. Hensle, S. Lambert, and C. Mendelsohn The development of the bladder trigone, the center of the anti-reflux mechanism Development, October 15, 2007; 134(20): 3763 - 3769. [Abstract] [Full Text] [PDF]

				K. Zarbalis, J. A. Siegenthaler, Y. Choe, S. R. May, A. S. Peterson, and S. J. Pleasure Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development PNAS, August 28, 2007; 104(35): 14002 - 14007. [Abstract] [Full Text] [PDF]

				O. Michos, A. Goncalves, J. Lopez-Rios, E. Tiecke, F. Naillat, K. Beier, A. Galli, S. Vainio, and R. Zeller Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis Development, July 1, 2007; 134(13): 2397 - 2405. [Abstract] [Full Text] [PDF]

				A. Iizuka-Kogo, T. Ishidao, T. Akiyama, and T. Senda Abnormal development of urogenital organs in Dlgh1-deficient mice Development, May 1, 2007; 134(9): 1799 - 1807. [Abstract] [Full Text] [PDF]

				Y. A. Ito, T. K. Footz, T. C. Murphy, W. Courtens, and M. A. Walter Analyses of a Novel L130F Missense Mutation in FOXC1 Arch Ophthalmol, January 1, 2007; 125(1): 128 - 135. [Abstract] [Full Text] [PDF]

				J. C. Clarke, S. R. Patel, R. M. Raymond Jr, S. Andrew, B. G. Robinson, G. R. Dressler, and P. D. Brophy Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage Hum. Mol. Genet., December 1, 2006; 15(23): 3420 - 3428. [Abstract] [Full Text] [PDF]

				S. Boyle and M. de Caestecker Role of transcriptional networks in coordinating early events during kidney development Am J Physiol Renal Physiol, July 1, 2006; 291(1): F1 - F8. [Abstract] [Full Text] [PDF]

				F. B. Berry, F. Mirzayans, and M. A. Walter Regulation of FOXC1 Stability and Transcriptional Activity by an Epidermal Growth Factor-activated Mitogen-activated Protein Kinase Signaling Cascade J. Biol. Chem., April 14, 2006; 281(15): 10098 - 10104. [Abstract] [Full Text] [PDF]

				H. Fujita, M. Kang, M. Eren, L. A. Gleaves, D. E. Vaughan, and T. Kume Foxc2 Is a Common Mediator of Insulin and Transforming Growth Factor {beta} Signaling to Regulate Plasminogen Activator Inhibitor Type I Gene Expression Circ. Res., March 17, 2006; 98(5): 626 - 634. [Abstract] [Full Text] [PDF]

				D. Grote, A. Souabni, M. Busslinger, and M. Bouchard Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney Development, January 1, 2006; 133(1): 53 - 61. [Abstract] [Full Text] [PDF]

				Z. Zhang, F. Cerrato, H. Xu, F. Vitelli, M. Morishima, J. Vincentz, Y. Furuta, L. Ma, J. F. Martin, A. Baldini, et al. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development Development, December 1, 2005; 132(23): 5307 - 5315. [Abstract] [Full Text] [PDF]

				M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al. Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068. [Abstract] [Full Text] [PDF]

				A. Kobayashi, K.-M. Kwan, T. J. Carroll, A. P. McMahon, C. L. Mendelsohn, and R. R. Behringer Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development Development, June 15, 2005; 132(12): 2809 - 2823. [Abstract] [Full Text] [PDF]

				F. B. Berry, M. A. O'Neill, M. Coca-Prados, and M. A. Walter FOXC1 Transcriptional Regulatory Activity Is Impaired by PBX1 in a Filamin A-Mediated Manner Mol. Cell. Biol., February 15, 2005; 25(4): 1415 - 1424. [Abstract] [Full Text] [PDF]

				O. H. Yu, I. J. Murawski, D. B. Myburgh, and I. R. Gupta Overexpression of RET leads to vesicoureteric reflux in mice Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1123 - F1130. [Abstract] [Full Text] [PDF]

				A. S. Woolf, K. L. Price, P. J. Scambler, and P. J.D. Winyard Evolving Concepts in Human Renal Dysplasia J. Am. Soc. Nephrol., April 1, 2004; 15(4): 998 - 1007. [Abstract] [Full Text] [PDF]

				M. M. Shah, R. V. Sampogna, H. Sakurai, K. T. Bush, and S. K. Nigam Branching morphogenesis and kidney disease Development, April 1, 2004; 131(7): 1449 - 1462. [Abstract] [Full Text] [PDF]

				Y. Wang, H. Zhao, X. Zhang, and H. Feng Novel Identification of a Four-base-pair Deletion Mutation in PITX2 in a Rieger Syndrome Family Journal of Dental Research, December 1, 2003; 82(12): 1008 - 1012. [Abstract] [Full Text] [PDF]

				R. A. Saleem, T. C. Murphy, J. M. Liebmann, and M. A. Walter Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4608 - 4612. [Abstract] [Full Text] [PDF]

				P.-X. Xu, W. Zheng, L. Huang, P. Maire, C. Laclef, and D. Silvius Six1 is required for the early organogenesis of mammalian kidney Development, July 15, 2003; 130(14): 3085 - 3094. [Abstract] [Full Text] [PDF]

				A. Majumdar, S. Vainio, A. Kispert, J. McMahon, and A. P. McMahon Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development Development, July 15, 2003; 130(14): 3175 - 3185. [Abstract] [Full Text] [PDF]

				O. J. Lehmann, S. Tuft, G. Brice, R. Smith, A. Blixt, R. Bell, B. Johansson, T. Jordan, R. A. Hitchings, P. T. Khaw, et al. Novel Anterior Segment Phenotypes Resulting from Forkhead Gene Alterations: Evidence for Cross-Species Conservation of Function Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2627 - 2633. [Abstract] [Full Text] [PDF]

				D. Ribes, E. Fischer, A. Calmont, and J. Rossert Transcriptional Control of Epithelial Differentiation during Kidney Development J. Am. Soc. Nephrol., June 1, 2003; 14(90001): S9 - 15. [Full Text] [PDF]