Arenas, E., Trupp, M., Akerud, P. and Ibanez, C. F (1995). GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15, 1465-1473.[Medline]
Baloh, R. H., Gorodinsky, A., Golden, J. P., Tansey, M. G., Keck, C. L., Popescu, N. C., Johnson, E. M. J. and Milbrandt, J (1998). GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 95, 5801-5806.[Abstract/Free Full Text]
Baloh, R. H., Tansey, M. G., Golden, J. P., Creedon, D. J., Heuckeroth, R. O., Keck, C. L., Zimonjic, D. B., Popescu, N. C., Johnson, E. M. J. and Milbrandt, J (1997). TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18, 793-802.[Medline]
Baloh, R. H., Tansey, M. G., Lampe, P. A., Fahrner, T. J., Enomoto, H., Simburger, K. S., Leitner, M. L., Araki, T., Johnson, E. M. and Milbrandt, J (1998). Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFR3-RET Receptor Complex. Neuron 21, 1291-1302.[Medline]
Bengzon, J., Kokaia, Z., Ernfors, P., Kokaia, M., Leanza, G., Nilsson, O. G., Persson, H. and Lindvall, O (1993). Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling. Neuroscience 53, 433-446.[Medline]
Birren, S. J., Verdi, J. M. and Anderson, D. J (1992). Membrane depolarization induces p140trk and NGF responsiveness, but not p75LNGFR, in MAH cells. Science 257, 395-397.[Abstract/Free Full Text]
Buj-Bello, A., Adu, J., Pi\226on, L. G. P., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V. L. and Davies, A. M (1997). Neurturin responsiveness requires a GPI-linked receptor plus the Ret receptor tyrosine kinase. Nature 387, 721-724.[Medline]
Buj-Bello, A., Buchman, V. L., Horton, A., Rosenthal, A. and Davies, A. M (1995). GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821-828.[Medline]
Buj-Bello, A., Pinon, L. G. and Davies, A. M (1994). The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development. Development 120, 1573-1580.[Abstract]
Cacalano, G., Farinas, I., Wang, L., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A. M., Reichardt, L. F., Hynes, M.,Davies, A. M. and Rosenthal, A (1998). GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21, 53-62.[Medline]
Cavicchioli, L., Flanigan, T. P., Vantini, G., Fusco, M., Polato, P., Toffano, G., Walsh, F. S. and Leon, A (1989). NGF amplifies expression of NGF receptor messenger RNA in forebrain cholinergic neurons of rats. Eur. J. Neurosci 1, 258-262.[Medline]
Chomczynski, P. and Sacchi, N (1987). Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]
Collins, F. and Lile, J. D (1989). The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival. Brain Res 502, 99-108.[Medline]
Creedon, D. J., Tansey, M. G., Baloh, R. H., Osborne, P. A., Lampe, P. A., Fahrner, T. J., Heuckeroth, R. O., Milbrandt, J. and Johnson, E. M. J (1997). Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc. Natl. Acad. Sci. USA 94, 7018-7023.[Abstract/Free Full Text]
Davies, A. M (1986). The survival and growth of embryonic proprioceptive neurons is promoted by a factor present in skeletal muscle. Dev. Biol 115, 56-67.[Medline]
Dugich-Djordjevic, M. M., Ohsawa, F., Okazaki, T., Mori, N., Day, J. R., Beck, K. D. and Hefti, F (1995). Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate. Neuroscience 66, 861-877.[Medline]
Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., Sariola, H. and Pachnis, V (1996). GDNF signalling through the Ret receptor tyrosine kinase. Nature 381, 789-793.[Medline]
Enokido, Y., de Sauvage, F., Hongo, J., Ninkina, N., Rosenthal, A., Buchman, V. and Davies, A. M (1998). GFRa-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr. Biol 8, 1019-1022.[Medline]
Enomoto, H., Araki, T., Jackman, A., Heuckeroth, R. O., Snider, W. D., Johnson, E. M., Jr. and Milbrandt, J (1998). GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 21, 317-324.[Medline]
Ernsberger, U., Sendtner, M. and Rohrer, H (1989). Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron 2, 1275-1284.[Medline]
Fusco, M., Polato, P., Vantini, G., Cavicchioli, L., Bentivoglio, M. andLeon, A (1991). Nerve growth factor differentially modulates theexpression of its receptor within the CNS. J. Comp. Neurol 312, 477-491.[Medline]
Ha, D. H., Robertson, R. T., Ribak, C. E. and Weiss, J. H (1996). Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor. J. Comp. Neurol 373, 451-465.[Medline]
Hebert, M. A., Van Horne, C. G., Hoffer, B. J. and Gerhardt, G. A (1996). Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. J. Pharmacol. Exp. Ther 279, 1181-1190.[Abstract/Free Full Text]
Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M. P., Simpson, L. C., Moffet, B., Vandlen, R. A., Koliatsos, V. E. and Rosenthal, A (1994). GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064.[Abstract/Free Full Text]
Heuckeroth, R. O., Lampe, P. A., Johnson, E. M. and Milbrandt, J (1998). Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Dev. Biol 200, 116-129.[Medline]
Higgins, G. A., Koh, S., Chen, K. S. and Gage, F. H (1989). NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron 3, 247-256.[Medline]
Holtzman, D. M., Li, Y., Parada, L. F., Kinsman, S., Chen, C. K., Valletta, J. S., Zhou, J., Long, J. B. and Mobley, W. C (1992). p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9, 465-478.[Medline]
Horger, B. A., Nishimura, M. C., Armanini, M. P., Wang, L. C., Poulsen, K. T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., Jr., Milbrandt, J., Rosenthal, A., Bjorklund, A., Vandlen, R. A., Hynes,M. A. and Phillips, H. S (1998). Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci 18, 4929-4937.[Abstract/Free Full Text]
Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J. C., Hu, S., Altrock, B. W. and Fox, G. M (1996). GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85, 1113-1124.[Medline]
Jing, S., Yu, Y., Fang, M., Hu, Z., Holst, P. L., Boone, T., Delaney, J., Schultz, H., Zhou, R. and Fox, G. M (1997). GFR2 and GFR -3 are two new receptors for ligands of the GDNF family. J. Biol. Chem 272, 33111-33117.[Abstract/Free Full Text]
Klein, R. D., Sherman, D., Ho, W., Stone, D., Bennett, G. L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C., Takahashi, M. and Rosenthal, A (1997). A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387, 717-721.[Medline]
Koike, T., Martin, D. P. and Johnson, E. J (1989). Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells. Proc. Natl. Acad. Sci. USA 86, 6421-6425.[Abstract/Free Full Text]
Koike, T. and Tanaka, S (1991). Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+. Proc. Natl. Acad. Sci. USA 88, 3892-3896.[Abstract/Free Full Text]
Kojima, M., Ikeuchi, T. and Hatanaka, H (1994). Nerve growth factor induces trkA mRNA expression in cultured basal forebrain cholinergic neurons from 17-day fetal rats. Neurosci. Lett 169, 47-50.[Medline]
Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M. J. and Milbrandt, J (1996). Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384, 467-470.[Medline]
Larmet, Y., Dolphin, A. C. and Davies, A. M (1992). Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors. Neuron 9, 563-574.[Medline]
Li, L., Wu, W., Lin, L. F., Lei, M., Oppenheim, R. W. and Houenou, L. J (1995). Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 92, 9771-9775.[Abstract/Free Full Text]
Lin, L. H., Doherty, D. H., Lile, J. D., Bektesh, S. and Collins, F (1993). GDNF: A glial cell-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132.[Abstract/Free Full Text]
Lindsay, R. M., Shooter, E. M., Radeke, M. J., Misko, T. P., Dechant, G., Thoenen, H. and Lindholm, D (1990). Nerve growth factor regulates expression of the nerve growth factor receptor gene in adult sensory neurons. Euro. J. Neurosci 2, 389-396.[Medline]
Liou, J. C., Yang, R. S. and Fu, W. M (1997). Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures. J. Physiol. (Lond) 503, 129-139.
Meyer-Franke, A., Wilkinson, G. A., Kruttgen, A., Hu, M., Munro, E., Hanson, M. G. J., Reichardt, L. F. and Barres, B. A (1998). Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 21, 681-693.[Medline]
Milbrandt, J., de Sauvage, F. J., Fahrner, T. J., Baloh, R. H., Leitner, M. L., Tansey, M. G., Lampe, P. A., Heuckeroth, R. O., Kotzbauer, P. T., Simburger, K. S., Golden, J. P., Davie, J. A., Vejsada, R., Kato, A. C., Hynes, M., Sherman, D., Nishimura, M., Wang, L. C., Vandlen, R., Moffat, B., Klein, R. D., Poulsen, K., Gray, C., Garces, A., Henderson, C. E., Phillips, H. S. and Jr., J. E (1998). Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20, 245-253.[Medline]
Miller, F. D., Mathew, T. C. and Toma, J. G (1991). Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system. J. Cell Biol 112, 303-312.[Abstract/Free Full Text]
Miller, F. D., Speelman, A., Mathew, T. C., Fabian, J., Chang, E., Pozniak, C. and Toma, J. G (1994). Nerve growth factor derived from terminals selectively increases the ratio of p75 to trkA NGF receptors on mature sympathetic neurons. Dev. Biol 161, 206-217.[Medline]
Molliver, D. C., Wright, D. E., Leitner, M. L., Parsadanian, A. S., Doster, K., Wen, D., Yan, Q. and Snider, W. D (1997). IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19, 849-861.[Medline]
Moore, M. W., Klein, R. D., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reicherdt, L. F., Ryan, A. M., Carver-Moore, K. and Rosenthal, A (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76-79.[Medline]
Mount, H. T., Dean, D. O., Alberch, J., Dreyfus, C. F. and Black, I. B (1995). Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 9092-9096.[Abstract/Free Full Text]
Naveilhan, P., Baudet, C., Mikaels, A., Shen, L., Westphal, H. and Ernfors, P (1998). Expression and regulation of GFR3, a novel GDNF family receptor. Proc. Natl. Acad. Sci. USA 95, 1295-1300.[Abstract/Free Full Text]
Nguyen, Q. T., Parsadanian, A. S., Snider, W. D. and Lichtman, J. W (1998). Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle. Science 279, 1725-1729.[Abstract/Free Full Text]
Ninkina, N., Adu, J., Fischer, A., Pinon, L. G., Buchman, V. L. and Davies, A. M (1996). Expression and function of TrkB variants in developing sensory neurons. EMBO J 15, 6385-6393.[Medline]
Oppenheim, R. W., Houenou, L. J., Johnson, J. E., Lin, L. H., Li, L., Lo, A. C., Newsome, A. L., Prevette, D. M. and Wang, S (1995). Developing motoneurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373, 344-346.[Medline]
Pachnis, V., Mankoo, B. and Costantini, F (1993). Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119, 1005-1017.[Abstract]
Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., Sariola, H. and Westphal, H (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382, 73-76.[Medline]
Pothos, E. N., Davila, V. and Sulzer, D (1998). Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. J. Neurosci 18, 4106-4118.[Abstract/Free Full Text]
Ribchester, R. R., Thomson, D., Haddow, L. J. and Ushkaryov, Y. A (1998). Enhancement of spontaneous transmitter release at neonatal mouse neuromuscular junctions by the glial cell line-derived neurotrophic factor (GDNF). J. Physiol. (Lond) 512, 635-641.[Abstract/Free Full Text]
Salin, T., Mudo, G., Jiang, X. H., Timmusk, T., Metsis, M. and Belluardo, N (1995). Up-regulation of trkB mRNA expression in the rat striatum after seizures. Neurosci. Lett 194, 181-184.[Medline]
Sanchez, M. P., Silos-Santiago, I., Frisen, J., He, B., Sergio, S. A. and Barbacid, M (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70-73.[Medline]
Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L., Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R. B. and Cate, R (1997). Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci. USA 94, 6238-6243.[Abstract/Free Full Text]
Schuchardt, A., Srinivas, S., Pachnis, V. and Costantini, F (1995). Isolation and characterisation of a chicken homologue of the c- ret proto-oncogene. Oncogene 10, 641-649.[Medline]
Sohrabji, F., Greene, L. A., Miranda, R. C. and Toran-Allerand, C. D (1994). Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J. Neurobiol 25, 974-988.[Medline]
Suvanto, P., Wartiovaara, K., Lindahl, M., Arumae, U., Moshnyakov, M., Horelli-Kuitunen, N., Airaksinen, M. S., Palotie, A., Sariola, H. and Saarma, M (1997). Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Hum. Mol. Genet 6, 1267-1273.[Abstract/Free Full Text]
Thompson, J., Doxakis, E., Pi\226on, L. G. P., Strachan, P., Buj-Bello, A., Wyatt, S., Buchman, V. L. and Davies, A. M (1998). GFRa-4, a new GDNF family receptor. Mol. Cell. Neurosci 11, 117-126.[Medline]
Treanor, J., Goodman, L., de Sauvage, F., Stone, D., Poulsen, K., Beck, K., Gary, C., Armanini, M., Pollock, R., Hefti, F., Phillips, H., Goddard, A., Moore, M., Buj-Bello, A., Davies, A. M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C. and Rosenthal, A (1996). Characterization of a receptor for glial cell line-derived neurotrophic factor. Nature 382, 80-83.[Medline]
Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A., Sieber, B., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M. and Ibanez, C. F (1996). Functional receptor for GDNF encoded by the c- ret proto-oncogene. Nature 381, 785-789.[Medline]
Trupp, M., Raynoschek, C., Belluardo, N. and Ibanez, C. F (1998). Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-ret receptor tyrosine kinase. Mol. Cell. Neurosci 11, 47-63.[Medline]
Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E. and Ibanez, C. F (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol 130, 137-148.[Abstract/Free Full Text]
Tsuzuki, T., Takahashi, M., Asai, N., Iwashita, T., Matsuyama, M. andAsai, J (1995). Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10, 191-198.[Medline]
Vega, Q. C., Worby, C. A., Lechner, M. S., Dixon, J. E. and Dressler, G. R (1996). Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc. Natl. Acad. Sci. U S A 93, 10657-10661.[Abstract/Free Full Text]
Venero, J. L., Knusel, B., Beck, K. D. and Hefti, F (1994). Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience 59, 797-815.[Medline]
Verdi, J. M. and Anderson, D. J (1994). Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts. Neuron 13, 1359-1372.[Medline]
Verge, V. M., Merlio, J. P., Grondin, J., Ernfors, P., Persson, H., Riopelle, R. J., Hokfelt, T. and Richardson, P. M (1992). Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. J. Neurosci 12, 4011-4022.[Abstract]
Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B. and Olson, L (1997). Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. J. Neurosci 17, 8506-8519.[Abstract/Free Full Text]
Williams, L. R., Inouye, G., Cummins, V. and Pelleymounter, M. A (1996). Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor. J. Pharmacol. Exp. Ther 277, 1140-1151.[Abstract/Free Full Text]
Worby, C. A., Vega, Q. C., Chao, H. H., Seasholtz, A. F., Thompson, R. C. and Dixon, J. E (1998). Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J. Biol. Chem 273, 3502-3508.[Abstract/Free Full Text]
Worby, C. A., Vega, Q. C., Zhao, Y., Chao, H. H. J., Seasholtz, A. F. and Dixon, J. E (1996). Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J. Biol. Chem 271, 23619-23622.[Abstract/Free Full Text]
Wright, D. E. and Snider, W. D (1996). Focal expression of glial cell line-derived neurotrophic factor in developing mouse limb bud. Cell Tissue Res 286, 209-217.[Medline]
Wyatt, S. and Davies, A. M (1993). Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons. Development 119, 635-648.[Abstract]
Wyatt, S. and Davies, A. M (1995). Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development. J. Cell Biol 130, 1435-1446.[Abstract/Free Full Text]
Wyatt, S., Middleton, G., Doxakis, E. and Davies, A. M (1999). Selective regulation of TrkC expression by NT3 in developing sensory neurons. J. Neurosci 19, 6559-6570.[Abstract/Free Full Text]
Yan, Q., Matheson, C. and Lopez, O. T (1995). In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373, 341-344.[Medline]
Zurn, A. D., Baetge, E. E., Hammang, J. P., Tan, S. A. and Aebischer, P (1994). Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones. Neuroreport 6, 113-118.[Medline]
