Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

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Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Aza-Blanc, P., Ram\222rez-Weber, F.-A., Laget, M.-P., Schwartz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by hedgehog targets cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Basler, K. and Struhl, G (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.[Medline]

Bellusci, S., Furuta, Y., Rush, M. G., Henderson, R., Winnier, G. and Hogan, B. L (1997). Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124, 53-63.[Abstract]

Bitgood, M., Shen, L. and McMahon, A (1996). Sertoli cell signaling by Desert hedgehog regulates the male germline. Current Biol 6, 298-304.[Medline]

Bitgood, M. J. and McMahon, A. P (1995). Hedgehog an Bmp Genes Are Coexpressed at Many Diverse Sites of Cell-Cell Interaction in the Mouse Embryo. Dev. Biol 172, 126-138.[Medline]

Borycki, A., Brunk, B., Tajbakhsh, S., Buckingham, M., Chiang, C. and Emerson, C. P (1999). Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development 126, 4053-4063.[Abstract]

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of Sonic hedgehog by Gli 3 in mouse limb development. Mech. Dev 62, 175-182.[Medline]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Chiang, C., Swan, R. Z., Grachtchouk, M., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A (1999). Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev. Biol 205, 1-9.[Medline]

Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem 274, 8143-8152.[Abstract/Free Full Text]

Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.[Abstract]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Epstein, D. J., Marti, E., Scott, M. P. and McMahon, A. P (1996). Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-2894.[Abstract]

Epstein, D. J., McMahon, A. P. and Joyner, A. L (1999). Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and-independent mechanisms. Development 126, 281-292.[Abstract]

Ericson, J., Thor, S., Edlund, T., Jessell, T. M. and Yamada, T (1992). Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256, 1555-1560.[Abstract/Free Full Text]

Franz, T (1994). Extra-Toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain. Acta Anat 150, 38-44.[Medline]

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. and Scott, M. P (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 10, 301-312.[Abstract/Free Full Text]

Gossler, A. and Balling, R (1992). The molecular and genetic analysis of mouse development. Eur. J. Biochem 204, 5-11.[Medline]

Graves, L. E., Segal, S. and Goodwin, E. B (1999). TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. Nature 399, 802-805.[Medline]

Grindley, J. C., Bellusci, S., Perkins, D. and Hogan, B. L (1997). Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev. Biol 188, 337-348.[Medline]

Grove, E. A., Tole, S., Limon, J., Yip, L. and Ragsdale, C. W (1998). Thehem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 125, 2315-2325.[Abstract]

Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. and Orenic, T. V (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.[Abstract]

Hogan, B. L (1999). Morphogenesis. Cell 96, 225-233.[Medline]

Hui, C. C. and Joyner, A. L (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet 3, 241-246.[Medline]

Hui, C. C., Slusarski, D., Platt, K., Homgren, R. and Joyner, A (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interrupus , Gli, Gli-2, and Gli-3, in ectoderm and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol 162, 402-413.[Medline]

Hynes, M., Porter, J (1995). Induction of midbrain dopaminergic neurons by Sonic Hedgehog. Neuron 15, 35-44.[Medline]

Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.[Medline]

Ingham, P., Taylor, A., Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Johnson, R., Grenier, J., Scott, M (1995). patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121, 4161-4170.[Abstract]

Joyner, A., Kornberg, T., Coleman, K. G., Cox, D. and Martin, G. R (1985). Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43, 29-37.[Medline]

Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B (1988). The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332, 371-374.[Medline]

Kinzler, K. W. and Vogelstein, B (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell Biol 10, 634-642.[Abstract/Free Full Text]

Knecht, A. K. and Harland, R. M (1997). Mechanisms of dorsal-ventral patterning in noggin-induced neural tissue. Development 124, 2477-2488.[Abstract]

Krishnan, V., Pereira, F. A., Qui, Y., Chen, C.-H., Beachy, P. A., Tsai, S. Y. and Tsai, M.-J (1997). Mediation of Sonic Hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278, 1947-1950.[Abstract/Free Full Text]

Lee, J., Platt, K. A., Censullo, P. and Ruiz i Altaba, A (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552.[Abstract]

Lessing, D. and Nusse, R (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125, 1469-1476.[Abstract]

Lewis, K. E., Drossopoulou, G., Paton, I. R., Morrice, D. R., Robertson, K. E., Burt, D. W., Ingham, P. W. and Tickle, C (1999). Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development 126, 2397-2407.[Abstract]

Litingtung, Y., Lei, L., Westphal, H. and Chiang, C (1998). Sonic hedgehog is essential to foregut development. Nat. Genet 20, 58-61.[Medline]

Liu, C. Z., Yang, J. T., Yoon, J. W., Villavicencio, E., Pfendler, K., Walterhouse, D. and Iannaccone, P (1998). Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. Gene 209, 1-11.[Medline]

Marigo, V., Johnson, R., Vortkamp, A. and Tabin, C (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol 180, 273-283.[Medline]

Marine, J. C., Bellefroid, E. J., Pendeville, H., Martial, J. A. and Pieler, T (1997). A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm. Mech. Dev 63, 211-225.[Medline]

Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L (1998). Gli2 is required for induction of floor plate and adjacent cells, butnot most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.[Abstract]

Matise, M. P., Lustig, M., Sakurai, T., Grumet, M. and Joyner, A. L (1999). Ventral midline cells are required for the local control of commissural axon gudance in the mouse spinal cord. Development 126, 3649-3659.[Abstract]

Melton, D. W (1994). Gene targeting in the mouse. BioEssays 16, 633-638.[Medline]

Mering, C. v. and Basler, K (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Current Biol 9, 1319-1322.[Medline]

Methot, N. and Basler, K (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831.[Medline]

Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H., Chik, K. W., Shi, X. M., Tsui, L. C., Cheng, S. H (1997). Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113-123.[Abstract]

Mohler, J (1988). Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120, 1061-1072.[Abstract/Free Full Text]

Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C. and Plessis, A (1998). Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Current Biol 8, 583-586.[Medline]

Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M. and Hui, C. C (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus [see comments]. Nat. Genet 20, 54-57.[Medline]

Nagy, A., Rossant, J., Nagy, R., Abramow, N. W. and Roder, J. C (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl Acad. Sci. USA 90, 8424-8428.[Abstract/Free Full Text]

Ohlmeyer, J. T. and Kalderon, D (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753.[Medline]

Orenic, T. V., Slusarski, D. C., Kroll, K. L. and Holmgren, R. A (1990). Cloning and characterization of the segment polarity gene cubitus interruptus dominant of Drosophila. Genes Dev 4, 1053-1067.[Abstract/Free Full Text]

Parr, B. A., Shea, M. J., Vassileva, G. and McMahon, A. P (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119, 247-261.[Abstract]

Pavletich, N. P. and Pabo, C. O (1993). Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261, 1701-1707.[Abstract/Free Full Text]

Pepicelli, C. V., Lewis, P. M. and McMahon, A. P (1998). Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol 8, 1083-1086.[Medline]

Platt, K. A., Michaud, J. and Joyner, A. L (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev 62, 121-135.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Robbins, D. J., Nybakken, K. E., Kobayashi, R., Sisson, J. C., Bishop, J. M. and Therond, P. P (1997). Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell 90, 225-234.[Medline]

Roths, J. B., Foxworth, W. B., McArthur, M. J., Montgomery, C. A. and Kier, A. B (1999). Spontaneous and engineered mutant mice as models for experimental and comparative pathology: history, comparison, and developmental technology. Laboratory Animal Science 49, 12-34.[Medline]

Ruiz i Altaba, A (1998). Combinatorial Gli gene function in floor plate and neuronal induction by Sonic hedgehog. Development 125, 2203-2212.[Abstract]

Ruiz i Altaba, A (1999). Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216.[Abstract]

Ruiz i Altaba, A., Jessell, T. and Roelink, H (1995). Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Molec. Cell. Neurosci 6, 106-121.[Medline]

Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T. M (1995). Early stages of notchord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3. Dev. Biol 170, 299-313.[Medline]

Sasaki, H., Hui, C.-c., Nakafuku, M. and Kondoh, H (1997). A binding site for Gli proteins is essential for HNF-3 floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.[Abstract]

Sasaki, H., Nishizaki, Y., Hui, C. C., Nakafuku, M. and Kondoh, H (1999). Regulation of Gli2 and Gli3 activities by and amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.[Abstract]

Schimmang, T., Lemaistre, M., Vortkamp, A. and Ruther, U (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 116, 799-804.[Abstract]

Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121, 1625-1635.[Abstract]

Sisson, J. C., Ho, K. S., Suyama, K. and Scott, M. P (1997). Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90, 235-245.[Medline]

St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R. and McMahon, A. P (1998). Sonic hedgehog signaling is essential for hair development. Curr. Biol 8, 1058-1068.[Medline]

Tabata, T., Eaton, S. and Kornberg, T. B (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635-2645.[Abstract/Free Full Text]

Tabata, T. and Kornberg, T. B (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.[Medline]

Takebe, Y., Seiki, M., Fujisawa, J.-I., Hoy, P., Yokota, K., Arai, K.-I., Yoshida, M. and Arai, N (1988). SRpromoter: an efficient and versatile mammalian cDNA expression system composed of the Simian Virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Molec. Cell. Biol 8, 466-472.[Abstract/Free Full Text]

Takuma, N., Sheng, H. Z., Furuta, Y., Ward, J. M., Sharma, K., Hogan, B., Pfaff, S. L., Westphal, H., Kimura, S. and Mahon, K. A (1998). Formation of Rathke's pouch requires dual induction from the diencephalon. Development 125, 4835-4840.[Abstract]

Toresson, H., Mata de Urquiza, A., Fagerstrom, C., Perlmann, T. and Campbell, K (1999). Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development 126, 1317-1326.[Abstract]

Walterhouse, D., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. and Iannaccone, P (1993). gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev. Dyn 196, 91-102.[Medline]

Wood, S. A., Allen, N. D., Rossant, J., Auerbach, A. and Nagy, A (1993). Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature 365, 87-89.[Medline]

Zuniga, A., Haramis, A.-P., G., McMahon, A. P. and Zeller, R (1999). Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401, 598-602.[Medline]

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[Abstract] [Full Text] [PDF]

M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298.
[Abstract] [Full Text] [PDF]

J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy
The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells.
Cancer Res., August 1, 2006; 66(15): 7548 - 7553.
[Abstract] [Full Text] [PDF]

G R van den Brink and J C H Hardwick
Hedgehog Wnteraction in colorectal cancer
Gut, July 1, 2006; 55(7): 912 - 914.
[Full Text] [PDF]

Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation.
Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377.
[Abstract] [Full Text] [PDF]

S. Blaess, J. D. Corrales, and A. L. Joyner
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
Development, May 1, 2006; 133(9): 1799 - 1809.
[Abstract] [Full Text] [PDF]

J. D. Corrales, S. Blaess, E. M. Mahoney, and A. L. Joyner
The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
Development, May 1, 2006; 133(9): 1811 - 1821.
[Abstract] [Full Text] [PDF]

M. van Tuyl, J. Liu, F. Groenman, R. Ridsdale, R. N. N. Han, V. Venkatesh, D. Tibboel, and M. Post
Iroquois genes influence proximo-distal morphogenesis during rat lung development
Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L777 - L789.
[Abstract] [Full Text] [PDF]

S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults
N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma.
Cancer Res., March 1, 2006; 66(5): 2666 - 2672.
[Abstract] [Full Text] [PDF]

K. Saha and D. V. Schaffer
Signal dynamics in Sonic hedgehog tissue patterning
Development, March 1, 2006; 133(5): 889 - 900.
[Abstract] [Full Text] [PDF]

M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
Development, February 1, 2006; 133(3): 569 - 578.
[Abstract] [Full Text] [PDF]

L. Koziel, M. Wuelling, S. Schneider, and A. Vortkamp
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
Development, December 1, 2005; 132(23): 5249 - 5260.
[Abstract] [Full Text] [PDF]

M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
Development, October 1, 2005; 132(19): 4339 - 4351.
[Abstract] [Full Text] [PDF]

M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053.
[Abstract] [Full Text] [PDF]

M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al.
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068.
[Abstract] [Full Text] [PDF]

A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton
The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes
Blood, August 15, 2005; 106(4): 1296 - 1304.
[Abstract] [Full Text] [PDF]

V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba
Cooperative requirement of the Gli proteins in neurogenesis
Development, July 15, 2005; 132(14): 3267 - 3279.
[Abstract] [Full Text] [PDF]

V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708.
[Abstract] [Full Text] [PDF]

D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev., March 1, 2005; 19(5): 626 - 641.
[Abstract] [Full Text] [PDF]

A. McDermott, M. Gustafsson, T. Elsam, C.-C. Hui, C. P. Emerson Jr, and A.-G. Borycki
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
Development, January 15, 2005; 132(2): 345 - 357.
[Abstract] [Full Text] [PDF]

R. Zeller
It Takes Time to Make a Pinky: Unexpected Insights into How SHH Patterns Vertebrate Digits
Sci. Signal., November 16, 2004; 2004(259): pe53 - pe53.
[Abstract] [Full Text] [PDF]

J. D. Corrales, G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
Development, November 15, 2004; 131(22): 5581 - 5590.
[Abstract] [Full Text] [PDF]

A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Sheng, R. Parlato, N. Dathan, A. A. Dlugosz, and C. Missero
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
Hum. Mol. Genet., November 1, 2004; 13(21): 2595 - 2606.
[Abstract] [Full Text] [PDF]

M. Fuccillo, M. Rallu, A. P. McMahon, and G. Fishell
Temporal requirement for hedgehog signaling in ventral telencephalic patterning
Development, October 15, 2004; 131(20): 5031 - 5040.
[Abstract] [Full Text] [PDF]

P. Sanchez, A. M. Hernandez, B. Stecca, A. J. Kahler, A. M. DeGueme, A. Barrett, M. Beyna, M. W. Datta, S. Datta, and A. Ruiz i Altaba
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
PNAS, August 24, 2004; 101(34): 12561 - 12566.
[Abstract] [Full Text] [PDF]

C. Cui, T. Elsam, Q. Tian, J. T. Seykora, M. Grachtchouk, A. Dlugosz, and H. Tseng
Gli Proteins Up-Regulate the Expression of Basonuclin in Basal Cell Carcinoma
Cancer Res., August 15, 2004; 64(16): 5651 - 5658.
[Abstract] [Full Text] [PDF]

Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
Development, August 1, 2004; 131(15): 3593 - 3604.
[Abstract] [Full Text] [PDF]

C. Wolff, S. Roy, K. E. Lewis, H. Schauerte, G. Joerg-Rauch, A. Kirn, C. Weiler, R. Geisler, P. Haffter, and P. W. Ingham
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
Genes & Dev., July 1, 2004; 18(13): 1565 - 1576.
[Abstract] [Full Text] [PDF]

L. Lum and P. A. Beachy
The Hedgehog Response Network: Sensors, Switches, and Routers
Science, June 18, 2004; 304(5678): 1755 - 1759.
[Abstract] [Full Text] [PDF]

H. Petropoulos, P. J. Gianakopoulos, A. G. Ridgeway, and I. S. Skerjanc
Disruption of Meox or Gli Activity Ablates Skeletal Myogenesis in P19 Cells
J. Biol. Chem., June 4, 2004; 279(23): 23874 - 23881.
[Abstract] [Full Text] [PDF]

K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
Development, June 1, 2004; 131(11): 2521 - 2532.
[Abstract] [Full Text] [PDF]

V. Palma and A. R. i Altaba
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
Development, January 15, 2004; 131(2): 337 - 345.
[Abstract] [Full Text] [PDF]

L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
Development, December 22, 2003; 130(25): 6233 - 6243.
[Abstract] [Full Text] [PDF]

E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
PNAS, November 11, 2003; 100(23): 13424 - 13429.
[Abstract] [Full Text] [PDF]

R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
Development, April 15, 2003; 130(8): 1549 - 1564.
[Abstract] [Full Text] [PDF]

E. Roessler and M. Muenke
How a Hedgehog might see holoprosencephaly
Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25.
[Abstract] [Full Text] [PDF]

C. B. Bai, W. Auerbach, J. S. Lee, D. Stephen, and A. L. Joyner
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Development, March 12, 2003; 129(20): 4753 - 4761.
[Abstract] [Full Text] [PDF]

P. Ybot-Gonzalez, P. Cogram, D. Gerrelli, and A. J. Copp
Sonic hedgehog and the molecular regulation of mouse neural tube closure
Development, March 7, 2003; 129(10): 2507 - 2517.
[Abstract] [Full Text] [PDF]

S. Unger, I. Copland, D. Tibboel, and M. Post
Down-Regulation of Sonic Hedgehog Expression in Pulmonary Hypoplasia Is Associated with Congenital Diaphragmatic Hernia
Am. J. Pathol., February 1, 2003; 162(2): 547 - 555.
[Abstract] [Full Text] [PDF]

P. Mill, R. Mo, H. Fu, M. Grachtchouk, P. C.W. Kim, A. A. Dlugosz, and C.-c. Hui
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
Genes & Dev., January 15, 2003; 17(2): 282 - 294.
[Abstract] [Full Text] [PDF]

A. M. Kenney, M. D. Cole, and D. H. Rowitch
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
Development, January 1, 2003; 130(1): 15 - 28.
[Abstract] [Full Text] [PDF]

H. L. Weiner, R. Bakst, M. S. Hurlbert, J. Ruggiero, E. Ahn, W. S. Lee, D. Stephen, D. Zagzag, A. L. Joyner, and D. H. Turnbull
Induction of Medulloblastomas in Mice by Sonic Hedgehog, Independent of Gli1
Cancer Res., November 15, 2002; 62(22): 6385 - 6389.
[Abstract] [Full Text] [PDF]

P. Dai, T. Shinagawa, T. Nomura, J. Harada, S. C. Kaul, R. Wadhwa, M. M. Khan, H. Akimaru, H. Sasaki, C. Colmenares, et al.
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
Genes & Dev., November 15, 2002; 16(22): 2843 - 2848.
[Abstract] [Full Text] [PDF]

M. Wijgerde, J. A. McMahon, M. Rule, and A. P. McMahon
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
Genes & Dev., November 15, 2002; 16(22): 2849 - 2864.
[Abstract] [Full Text] [PDF]

M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
Genes & Dev., November 15, 2002; 16(22): 2865 - 2878.
[Abstract] [Full Text] [PDF]

H. Sheng, S. Goich, A. Wang, M. Grachtchouk, L. Lowe, R. Mo, K. Lin, F. J. de Sauvage, H. Sasaki, C.-c. Hui, et al.
Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype
Cancer Res., September 15, 2002; 62(18): 5308 - 5316.
[Abstract] [Full Text] [PDF]

E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson
Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts
J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640.
[Abstract] [Full Text] [PDF]

L. E. Olson and M. G. Rosenfeld
Perspective: Genetic and Genomic Approaches in Elucidating Mechanisms of Pituitary Development
Endocrinology, June 1, 2002; 143(6): 2007 - 2011.
[Abstract] [Full Text] [PDF]

F. Kheradmand, K. Rishi, and Z. Werb
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2
J. Cell Sci., February 15, 2002; 115(4): 839 - 848.
[Abstract] [Full Text] [PDF]

J. Chen and D. E. Harrison
Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood
Blood, January 15, 2002; 99(2): 561 - 566.
[Abstract] [Full Text] [PDF]

M. Rallu, R. Machold, N. Gaiano, J. G. Corbin, A. P. McMahon, and G. Fishell
Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
Development, January 11, 2002; 129(21): 4963 - 4974.
[Abstract] [Full Text] [PDF]

M. K. Gustafsson, H. Pan, D. F. Pinney, Y. Liu, A. Lewandowski, D. J. Epstein, and C. P. Emerson Jr.
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
Genes & Dev., January 1, 2002; 16(1): 114 - 126.
[Abstract] [Full Text] [PDF]

C. B. Bai and A. L. Joyner
Gli1 can rescue the in vivo function of Gli2
Development, December 15, 2001; 128(24): 5161 - 5172.
[Abstract] [Full Text] [PDF]

N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
Development, December 15, 2001; 128(24): 5201 - 5212.
[Abstract] [Full Text] [PDF]

R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada
Unique functions of Sonic hedgehog signaling during external genitalia development
Development, November 1, 2001; 128(21): 4241 - 4250.
[Abstract] [Full Text] [PDF]

M. Mahlapuu, S. Enerback, and P. Carlsson
Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations
Development, June 15, 2001; 128(12): 2397 - 2406.
[Abstract] [Full Text] [PDF]

R. H. Costa, V. V. Kalinichenko, and L. Lim
Transcription factors in mouse lung development and function
Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L823 - L838.
[Abstract] [Full Text] [PDF]

M Treier, S O'Connell, A Gleiberman, J Price, D. Szeto, R Burgess, P. Chuang, A. McMahon, and M. Rosenfeld
Hedgehog signaling is required for pituitary gland development
Development, January 2, 2001; 128(3): 377 - 386.
[Abstract] [PDF]

B. Lake, R Ford, and K. Kao
Xrel3 is required for head development in Xenopus laevis
Development, January 1, 2001; 128(2): 263 - 273.
[Abstract] [PDF]

A. M. Kenney and D. H. Rowitch
Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
Mol. Cell. Biol., December 1, 2000; 20(23): 9055 - 9067.
[Abstract] [Full Text]

D. Epstein, L Martinu, J. Michaud, K. Losos, C Fan, and A. Joyner
Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS
Development, January 11, 2000; 127(21): 4701 - 4709.
[Abstract] [PDF]

P Aza-Blanc, H. Lin, A Ruiz i Altaba, and T. Kornberg
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
Development, January 10, 2000; 127(19): 4293 - 4301.
[Abstract] [PDF]

R Brewster, J. Mullor, and A Ruiz i Altaba
Gli2 functions in FGF signaling during antero-posterior patterning
Development, January 10, 2000; 127(20): 4395 - 4405.
[Abstract] [PDF]

Y. Koyabu, K. Nakata, K. Mizugishi, J. Aruga, and K. Mikoshiba
Physical and Functional Interactions between Zic and Gli Proteins
J. Biol. Chem., March 2, 2001; 276(10): 6889 - 6892.
[Abstract] [Full Text] [PDF]

X.-Q. Wang and J. A Rothnagel
Post-transcriptional Regulation of the GLI1 Oncogene by the Expression of Alternative 5' Untranslated Regions
J. Biol. Chem., January 5, 2001; 276(2): 1311 - 1316.
[Abstract] [Full Text] [PDF]

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				S. J. Hatsell and P. Cowin Gli3-mediated repression of Hedgehog targets is required for normal mammary development Development, September 15, 2006; 133(18): 3661 - 3670. [Abstract] [Full Text] [PDF]

				M. Grachtchouk, J. Liu, A. Wang, L. Wei, C. K. Bichakjian, J. Garlick, A. F. Paulino, T. Giordano, and A. A. Dlugosz Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans Am. J. Pathol., September 1, 2006; 169(3): 806 - 814. [Abstract] [Full Text] [PDF]

				M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]

				J. A. Sterling, B. O. Oyajobi, B. Grubbs, S. S. Padalecki, S. A. Munoz, A. Gupta, B. Story, M. Zhao, and G. R. Mundy The hedgehog signaling molecule gli2 induces parathyroid hormone-related Peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res., August 1, 2006; 66(15): 7548 - 7553. [Abstract] [Full Text] [PDF]

				G R van den Brink and J C H Hardwick Hedgehog Wnteraction in colorectal cancer Gut, July 1, 2006; 55(7): 912 - 914. [Full Text] [PDF]