Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth

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Basler, K., Christen, B. and Hafen, E (1991). Ligand-independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64, 1069-1081.[Medline]

Basler, K. and Hafen, E (1988). Control of photoreceptor cell fate by the Sevenless protein requires a functional tyrosine kinase domain. Cell 54, 299-311.[Medline]

Bergmann, A., Agapite, J., McCall, K. and Steller, H (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.[Medline]

Boguski, M. S. and McCormick, F (1993). Proteins regulating Ras and its relatives. Nature, 366, 643-654.[Medline]

Boehni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K. and Hafen, E (1999). Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97, 865-875.[Medline]

Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., III, Zipursky, S. L. and Hafen, E (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888.[Medline]

Burge, C. and Karlin, S (1997). Prediction of complete gene structures in human genomic DNA. J. Mol. Biol 268, 78-94.[Medline]

Chakrabarti, L., Knight, S. J., Flannery, A. V. and Davies, K. E (1996). A candidate gene for mild mental handicap at the FRAXE fragile site. Hum. Mol. Genet 5, 275-282.[Abstract/Free Full Text]

Day, S. J. and Lawrence, P. A (2000). Measuring dimensions, the regulation of size and shape. Development 127, 2977-2987.[Abstract]

Di Cristofano, A. and Pandolfi, P. P (2000). The multiple roles of PTEN in tumor suppression. Cell 100, 387-390.[Medline]

Diaz-Benjumea, F. J. and Hafen, E (1994). The Sevenless signaling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120, 569-578.[Abstract]

Dickson, B., Sprenger, F., Morrison, D. and Hafen, E (1992). Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360, 600-603.[Medline]

Dickson, B. J., van der Straten, A., Dominguez, M. and Hafen, E (1996). Mutations modulating Raf signaling in Drosophila eye development. Genetics 142, 163-171.[Abstract]

Domer, P. H., Fakharzadeh, S. S., Chen, C. S., Jockel, J., Johansen, L., Silverman, G. A., Kersey, J. H. and Korsmeyer, S. J (1993). Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc. Natl. Acad. Sci. USA 90, 7884-7888.[Abstract/Free Full Text]

Dominguez, M., Wasserman, J. D. and Freeman, M (1998). Multiple functions of the EGF receptor in Drosophila eye development. Curr. Biol 8, 1039-1048.[Medline]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-567.[Medline]

Frame, S. and Balmain, A (2000). Integration of positive and negative growth signals during ras pathway activation in vivo. Curr. Opin. Genet. Dev 10, 106-113.[Medline]

Freeman, M (1997). Cell determination strategies in the Drosophila eye. Development 124, 261-270.[Abstract]

Gao, X., Neufeld, T. P. and Pan, D (2000). Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and-independent pathways. Dev. Biol 221, 404-418.[Medline]

Gecz, J., Gedeon, A. K., Sutherland, G. R. and Mulley, J. C (1996). Identification of the gene FMR2, associated with FRAXE mental retardation. Nat. Genet 13, 105-108.[Medline]

Gecz, J., Bielby, S., Sutherland, G. M. and Mulley, J. C (1997). Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators. Genomics 44, 201-213.[Medline]

Gille, H. and Downward, J (1999). Multiple Ras effector pathways contribute to G1 cell cycle progression. J. Biol. Chem 274, 22033-22040.[Abstract/Free Full Text]

Goberdhan, D. C., Paricio, N., Goodman, E. C., Mlodzik, M. and Wilson, C (1999). Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev 13, 3244-3258.[Abstract/Free Full Text]

Greaves, S., Sanson, B., White, P. and Vincent, J. P (1999). A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. Genetics 153, 1753-1766.[Abstract/Free Full Text]

Gu, Y., Shen, Y., Gibbs, R. A. and Nelson, D. L (1996). Identification of FMR2 , a novel gene associated with the FRAXE CCG repeat and CpG island. Nat. Genet., 13, 109-113.[Medline]

Hay, B. A., Maile, R. and Rubin, G. M (1997). P element insertion-dependent gene activation in the Drosophila eye. Proc. Natl. Acad. Sci. USA 94, 5195-200.[Abstract/Free Full Text]

Huang, H., Potter, C. J., Tao, W., Li, D. M., Brogiolo, W., Hafen, E., Sun, H. and Xu, T (1999). PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126, 5365-5372.[Abstract]

Isnard, P., Core, N., Naquet, P. and Djabali, M (2000). Altered lymphoid development in mice deficient for the mAF4 proto-oncogene. Blood, 96, 705-710.[Abstract/Free Full Text]

Jones, S. M., Klinghoffer, R., Prestwich, G. D., Toker, A. and Kazlauskas, A (1999). PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr. Biol 9, 512-521.[Medline]

Kurada, P. and White, K (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329.[Medline]

Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. and Waterfield, M. D (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J 15, 6584-6594.[Medline]

Levavasseur, F., Mandemakers, W., Visser, P., Broos, L., Grosveld, F., Zivkovic, D. and Meijer, D (1998). Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse. Mech. Dev 74, 89-98.[Medline]

Ma, C. and Staudt, L. M (1996). LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4 , the gene fused to MLL in t(4;11) leukemias. Blood 87, 734-745.[Abstract/Free Full Text]

Mahgoub, N., Parker, R. I., Hosler, M. R., Close, P., Winick, N. J., Masterson, M., Shannon, K. M. and Felix, C. A (1998). Ras mutations in pediatric leukemias with MLL gene rearrangements. Genes Chromosomes Cancer 21, 270-275.[Medline]

Melnick, M. B., Perkins, L. A., Lee, M., Ambrosio, L. and Perrimon, N (1993). Developmental and molecular characterization of mutations in the Drosophila - raf serine/threonine protein kinase. Development 118, 127-138.[Abstract]

Miller, W. J., Skinner, J. A., Foss, G. S. and Davies, K. E (2000). Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain. Eur. J. Neurosci 12, 381-384.[Medline]

Mlodzik, M., Baker, N. E. and Rubin, G. M (1990). Isolation and expression of scabrous , a gene regulating neurogenesis in Drosophila. Genes Dev 4, 1848-1861.[Abstract/Free Full Text]

Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S. C. and Thomas, G (1999). Drosophila S6 kinase, a regulator of cell size. Science 285, 2126-2129.[Abstract/Free Full Text]

Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R. P., Lange, B., Crist, W. M., Nowell, P. C. and et al. ( (1993). Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc. Natl. Acad. Sci. USA 90, 4631-4635.[Abstract/Free Full Text]

Neufeld, T. P., Tang, A. H. and Rubin, G. M (1998). A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. Genetics 148, 277-286.[Abstract/Free Full Text]

Newsome, T. P., Asling, B. and Dickson, B. J (2000). Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127, 851-860.[Abstract]

Nilson, I., Reichel, M., Ennas, M. G., Greim, R., Knorr, C., Siegler, G., Greil, J., Fey, G. H. and Marschalek, R (1997). Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. Br. J. Haematol 98, 157-169.[Medline]

Oldham, S., Boehni, R., Stocker, H., Broggiolo, W. and Hafen, E (2001). Genetic control of size in Drosophila. Phil. Trans. R. Soc. Lond 355, 945-952.

Perrimon, N., Lanjuin, A., Arnold, C. and Noll, E (1996). Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics 144, 1681-1692.[Abstract]

Prober, D. A. and Edgar, B. A (2000). Ras1 promotes cellular growth in the Drosophila wing. Cell 100, 435-446.[Medline]

Rameh, L. E. and Cantley, L. C (1999). The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem 274, 8347-8350.[Free Full Text]

Rebay, I., Chen, F., Hsiao, F., Kolodziej, P. A., Kuang, B. H., Laverty, T., Suh, C., Voas, M., Williams, A. and Rubin, G. M (2000). A genetic screen for novel components of the Ras/Mitogen-Activated Protein Kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154, 695-712.[Abstract/Free Full Text]

Reeves, R. and Nissen, M. S (1990). The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J. Biol. Chem 265, 8573-8582.[Abstract/Free Full Text]

Rommel, C. and Hafen, E (1998). Ras \320 a versatile cellular switch. Curr. Opin. Genet. Dev 8, 412-418.[Medline]

Taki, T., Kano, H., Taniwaki, M., Sako, M., Yanagisawa, M. and Hayashi, Y (1999). AF5q31 , a newly identified AF4 -related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc. Natl. Acad. Sci. USA 96, 14535-14540.[Abstract/Free Full Text]

Tang, A. H., Neufeld, T. P., Rubin, G. M. and Muller, H.-A. J (2001). Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. Development 128, 801-813.[Abstract]

Tautz, D. and Pfeifle, C (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.[Medline]

Torok, T., Tick, G., Alvarado, M. and Kiss, I (1993). P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster , isolation of lethals with different overgrowth phenotypes. Genetics 135, 71-80.[Abstract]

Weinkove, D. and Leevers, S. J (2000). The genetic control of organ growth, insights from Drosophila. Curr. Opin. Genet. Dev 10, 75-80.[Medline]

Weinkove, D., Neufeld, T. P., Twardzik, T., Waterfield, M. D. and Leevers, S. J (1999). Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol 9, 1019-1029.[Medline]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development, 117, 1223-1237.[Abstract]

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				A. Khokhar, N. Chen, J.-P. Yuan, Y. Li, G. N. Landis, G. Beaulieu, H. Kaur, and J. Tower Conditional Switches for Extracellular Matrix Patterning in Drosophila melanogaster Genetics, March 1, 2008; 178(3): 1283 - 1293. [Abstract] [Full Text] [PDF]

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				J. W. P. Yam, D.-Y. Jin, C. W. So, and L. C. Chan Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein Blood, February 15, 2004; 103(4): 1445 - 1453. [Abstract] [Full Text] [PDF]

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