Adachi, M., Fukuda, M. and Nishida, E (1999). Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBOJ 18, 5347-5358.[Medline]
Allard, J. D., Chang, H. C., Herbst, R., McNeill, H. and Simon, M. A (1996). The SH2-containing tyrosine phosphatase Corkscrew is required during signaling by Sevenless, Ras1 and Raf. Development 122, 1137-1146.[Abstract]
Biggs, W. H. and Zipursky, S. L (1992). Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase. Proc. Natl. Acad. Sci. USA 89, 6295-6299.[Abstract/Free Full Text]
Brabant, M. C., Fristrom, D., Bunch, T. A. and Brower, D. L (1996). Distinct spatial and temporal functions for PS integrins during Drosophila wing morphogenesis. Development 122, 3307-3317.[Abstract]
Brabant, M. C., Fristrom, D., Bunch, T. A., Baker, S. E. and Brower, D.L (1998). The PS integrins are required for a regulatory event during Drosophila wing morphogenesis. Annals New York Acad. Sci 857, 99-109.[Medline]
Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a meansof altering cell fates and generating dominant phenotypes. Development 118, 253-272.
Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888.[Medline]
H., Sarnecki, C. and Blenis, J (1992). Nuclear localization and regulation of erk -and rsk -encoded protein kinases. Mol. Cell. Biol 12, 915-927.[Abstract/Free Full Text]
Cleghon, V., Gayko, U., Copeland, T. D., Perkins, L. A., Perrimon, N. and Morrison, D. K (1996). Specific phosphotyrosine residues on the Drosophila Torso RTK mediate both positive and negative signaling events that are compensatory. Genes Dev 10, 566-577.[Abstract/Free Full Text]
Cleghon, V., Feldmann, P., Ghiglione, C., Copeland, T. D., Perrimon, N., Hughes, D. A. and Morrison, D. K (1998). Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol. Cell 2, 719-727.
Cole, C. N. and Hammell, C. M (1998). Nucleocytoplasmic transport: Driving and directing transport. Curr. Biol 8, 368-.
de Celis, J. F (1998). Positioning and differentiation of veins in the Drosophila wing. Int. J. Dev. Biol 42, 335-343.[Medline]
Dikic, I., Schlessinger, J. and Lax, I (1994). PC12 cells overexpressing the insulin receptor undergo insulin dependent neuronal differentiation. Curr. Biol 4, 702-708.[Medline]
Erdelyi, M., M\207the, E. and Szabad, J (1997). Genetic and developmental analysis of mutant ketel alleles that identify the Drosophila importin-homologue. Acta Biol. Hung 48, 323-338.[Medline]
Feldmann, P., Eicher, E. N., Leevers, S. J., Hafen, E. and Hughes, D. A (1999). Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein. Mol. Cell. Biol 19, 1928-1937.[Abstract/Free Full Text]
Ferrigno, P., Posas, F., Koepp, D., Saito, H. and Silver, P. A (1998). Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the Importinhomologs NMD5 and XPO1. EMBO J 17, 5606-5614.[Medline]
Fukuda, M., Gotoh, I., Gotoh, Y. and Nishida, E (1996). Cytoplasmic localization of MAP kinase directed by its N-terminal leucine-rich short amino acid sequence, which acts as a nuclear export signal. J. Biol. Chem 271, 20024-20028.[Abstract/Free Full Text]
Fukuda, M., Gotoh, Y. and Nishida, E (1997). Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J 16, 1901-1908.[Medline]
Z (1997). In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277, 1103-1106.[Abstract/Free Full Text]
Gabay, L., Seger, R. and Shilo, B.-Z (1997). MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 124, 3535-3541.[Abstract]
Ghiglione, C., Perrimon, N. and Perkins, L. A (1999). The role of quantitative variations in the level of MAPK activity in patterning the Drosophila embryonic termini. Dev. Biol 205, 181-193.[Medline]
Gonzalez, F., Seth, A., Raden, D. L., Bowman, D. S., Fay, F. S. and Davis, R. J (1993). Serum-induced translocation of mitogen activated protein kinase to the cell surface ruffling membrane and the nucleus. J. Cell Biol 122, 1089-1101.[Abstract/Free Full Text]
G\232rlich, D (1998). Transport into and out of the cell nucleus. EMBO J 17, 2721-2727.[Medline]
G\232rlich, D., Dabrowshki, M., Bischoff, F. R, Kutay, U., Bork, P., Hartmann, E., Prehn, S. and Izaurralde, E (1997). A novel class of RanGTP binding proteins. J. Cell Biol 138, 65-80.[Abstract/Free Full Text]
Gyuris, J., Golemis, E., Chertkov, H. and Brent, R (1993). Cdi1, a humanG1 and S protein phosphatase that associates with Cdk2. Cell 75, 791-803.[Medline]
Han, Z. S., Enslen, H., Hu, X., Meng, X., Wu, I.-H., Barrett, T., Davis, R.J. and Ip, Y. T (1998). A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol 18, 3527-2539.[Abstract/Free Full Text]
Heffetz, D., Bushkin, I., Dror, R. and Zick, Y (1990). The insulinomimetic agents H2O2and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem 265, 2896-2902.[Abstract/Free Full Text]
Herbst, R., Carroll. P. M., Allard, J. D., Schilling, J., Raabe, T. and Simon, M. A (1996). Daughter of Sevenless is a substrate of the phosphotyrosinephosphatase Corkscrew and functions during Sevenless signaling. Cell 85, 899-909.[Medline]
Herskowitz, I (1995). MAP kinase pathways in yeast: For mating and more. Cell 80, 187-197.[Medline]
Hill, C. S. and Treisman, R (1995). Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80, 199-211.[Medline]
J\212kel, S. and G\232rlich, D (1998). Importin, transportin, RanBP5, and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J 17, 4491-4502.[Medline]
J\212kel, S., Albig, W., Kutay, U., Bischoff, F. R., Schwamborn, K., Doenecke, D. and G\232rlich, D (1999). The importin/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J 18, 2411-2423.[Medline]
Khokhlatchev, A. V., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E. and Cobb, M. H (1998). Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 93, 605-615.[Medline]
Kl\212mbt, C., Glazer, L. and Shilo, B.-Z (1992). breathless, a Drosophila FGF receptor homolog is essential for migration of tracheal and specific midline glial cells. Genes Dev 6, 1668-1678.[Abstract/Free Full Text]
Kumar, J. P. Tio, M., Hsiung, Akopyan, S., Gabay, L., Seger, R., Shilo, B., Moses, K (1998). Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125, 3875-3885.[Abstract]
Lee, T., Hacohen, N., Krasnow, M. and Montell, D. J (1996). Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes Dev 10, 2912-2921.[Abstract/Free Full Text]
Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A. and Pouyssegur, J (1993). Growth factors induce nuclear translocation of MAP kinase (p42mapkand p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J. Cell Biol 122, 1079-1088.[Abstract/Free Full Text]
Lewis, T. S., Shapiro, P. S. and Ahn, N. G (1998). Signal transduction through MAP kinase cascades. Adv. Cancer Res 74, 49-139.[Medline]
Li, W. and Perrimon, N (1997). Specificity of receptor tyrosine kinase signaling pathways: Lessons from Drosophila. Genet. Eng 19, 167-182.
Lu, X., Chou, T. B., Williams, N. G., Roberts, T. and Perrimon, N (1993). Control of cell fate determination by p21ras, an essential component of Torso signaling in Drosophila. Genes Dev 7, 621-632.[Abstract/Free Full Text]
Marshall, C. J (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.[Medline]
Michelson, A. M (1994). Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm. Development 120, 755-768.[Abstract]
Moore, M. S (1998). Ran and nuclear transport. J. Biol. Chem 273, 22857-22860.[Free Full Text]
Perkins, L. A., Larsen, I. and Perrimon, N (1992). corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase Torso. Cell 70, 225-236.[Medline]
Perkins, L. A., Johnson, M. R., Melnick, M. B. and Perrimon, N (1996). The non-receptor protein tyrosine phosphatase Corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev. Biol 180, 63-81.[Medline]
Perrimon, N. and Perkins, L (1997). There must be 50 ways to rule the signal: The case of the Drosophila EGF receptor. Cell, 89, 13-16.[Medline]
Perrimon, N., Lu, X., Hou, X. S., Hsu, J. C., Melnick, M. B., Chou, T. B., Perkins, L. A (1995). Dissection of the torso signal transduction pathway in Drosophila. Mol. Reprod. Dev 42, 515-522.[Medline]
Raabe, T (2000). The Sevenless signaling pathway: variations of a common theme. Biochim. Biophys. Acta 1496, 151-163.[Medline]
Raabe, T., Riesgo-Escovar, J., Liu, X., Bausenwein, B. S., Deak, P., Mar\232y, P. and Hafen, E (1996). DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between Sevenless and Ras1 in Drosophila. Cell 85, 911-920.[Medline]
Reichman-Fried, M., Dickson, B., Hafen, E. and Shilo, B.-Z (1994). Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev 8, 428-439.[Abstract/Free Full Text]
Riesgo-Escovar, J. R., Jenni, M., Fritz, A. and Hafen, E (1996). The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for Djun-dependent cell fate specification in the eye. Genes Dev 10, 2759-2768.[Abstract/Free Full Text]
Robinson, M. J. and Cobb, M. H (1997). Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol 9, 180-186.[Medline]
Schweitzer, R. and Shilo, B.-Z (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Gen 13, 191-196.[Medline]
Sluss, H. K., Han, Z., Barrett, T., Davis, R. J. and Ip, Y. T (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev 10, 2745-2758.[Abstract/Free Full Text]
Stroumbakis, N. D., Li, Z. and Tolias, P. P (1994). RNA-and single-stranded DNA-binding (SSB) proteins expressed during Drosophila melanogaster oogenesis: A homolog of bacterial and eukaryotic mitochondrial SSBs. Gene 143, 171-177.[Medline]
Tautz, D. and Pfeifle, C (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.[Medline]
Traverse, S., Seedorf, K., Paterson, H., Marshall, C. J., Cohen, P. and Ullrich, A (1994). EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol 4, 694-701.[Medline]
Van der Geer, P., Hunter, T. and Lindberg, R. A (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol 10, 251-337.[Medline]
Wappner, P., Gabay, L. and Shilo, B. Z (1997). Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes. Development 124, 4707-4716.[Abstract]
Yung, Y., Dolginov, Y., Yoa, Z., Rubinfeld, H., Michael, D., Hanoch, T., Roubini, E., Lando, Z., Zharhary, D. and Seger, R (1997). Detection of ERK activation by a novel monoclonal antibody. FEBS Lett 408, 292-296.[Medline]
