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First published online 16 September 2003
doi: 10.1242/dev.00722

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Development 130, 5351-5362 (2003)
Copyright © 2003 The Company of Biologists Limited

Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons

Josette M. Ungos1,2, Rolf O. Karlstrom3 and David W. Raible1,2,*

1 Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195-7420 USA
2 Department of Biological Structure, University of Washington, Seattle, WA 98195-7420 USA
3 Department of Biology, University of Massachusetts, Amherst, MA 01003, USA

* Author for correspondence (e-mail: draible{at}u.washington.edu)

Accepted 10 July 2003

Hedgehog (Hh) signal transduction is directly required in zebrafish DRG precursors for proper development of DRG neurons. Zebrafish mutations in the Hh signaling pathway result in the absence of DRG neurons and the loss of expression of neurogenin1 (ngn1), a gene required for determination of DRG precursors. Cell transplantation experiments demonstrate that Hh acts directly on DRG neuron precursors. Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression. These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors.

Key words: Dorsal root ganglia, Hedgehog, Cyclopamine, Neurogenin, Neural crest, Zebrafish


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© The Company of Biologists Ltd 2003