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First published online 5 November 2003
doi: 10.1242/dev.00868

Development 130, 6221-6231 (2003)
Published by The Company of Biologists 2003
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Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor

Rugao Liu1,*, Jun Cai1,*, Xuemei Hu1,*, Min Tan1, Yingchuan Qi1, Michael German2, John Rubenstein3, Maike Sander4 and Mengsheng Qiu1,{dagger}

1 Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
2 Department of Medicine, University of California, San Francisco, CA 94143, USA
3 Department of Psychiatry, University of California, San Francisco, CA 94143, USA
4 Department of Developmental and Cell Biology, University of California at Irvine, 4228 McGaugh Hall, Irvine CA 92697-2300, USA

{dagger} Author for correspondence (e-mail: m0qiu001{at}louisville.edu)

Accepted 10 September 2003

During early neural development, the Nkx6.1 homeodomain neural progenitor gene is specifically expressed in the ventral neural tube, and its activity is required for motoneuron generation in the spinal cord. We report that Nkx6.1 also controls oligodendrocyte development in the developing spinal cord, possibly by regulating Olig gene expression in the ventral neuroepithelium. In Nkx6.1 mutant spinal cords, expression of Olig2 in the motoneuron progenitor domain is diminished, and the generation and differentiation of oligodendrocytes are significantly delayed and reduced. The regulation of Olig gene expression by Nkx6.1 is stage dependent, as ectopic expression of Nkx6.1 in embryonic chicken spinal cord results in an induction of Olig2 expression at early stages, but an inhibition at later stages. Moreover, the regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 also appears to be region specific. In the hindbrain, unlike in the spinal cord, Olig1 and Olig2 can be expressed both inside and outside the Nkx6.1-expressing domains and oligodendrogenesis in this region is not dependent on Nkx6.1 activity.

Key words: Oligodendrocyte development, Nkx6.1 mutation, In ovo electroporation, Spinal cord, Olig2, Nkx2.2


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