spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 19 May 2004
doi: 10.1242/dev.01160

Development 131, 2887-2897 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Movies
Right arrow All Versions of this Article:
dev.01160v1
131/12/2887    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rupp, P. A.
Right arrow Articles by Little, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rupp, P. A.
Right arrow Articles by Little, C. D.

{alpha}vß3 integrin-dependent endothelial cell dynamics in vivo

Paul A. Rupp1, András Czirók1,2 and Charles D. Little1,*

1 Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
2 Department of Biological Physics, Eötvös University, Pázmány sétány 1A, Budapest, 1117 Hungary

* Author for correspondence (e-mail: clittle{at}kumc.edu)

Accepted 9 March 2004

A major challenge confronting developmental cell biologists is to understand how individual cell behaviors lead to global tissue organization. Taking advantage of an endothelial cell-specific marker and scanning time-lapse microscopy, we have examined the formation of the primary vascular pattern during avian vasculogenesis. Five types of distinguishable endothelial cell motion are observed during formation of a vascular plexus: (1) global tissue deformations that passively convect endothelial cells; (2) vascular drift, a sheet-like medial translocation of the entire vascular plexus; (3) structural rearrangements, such as vascular fusion; (4) individual cell migration along existing endothelial structures; and (5) cell process extension into avascular areas, resulting in new links within the plexus. The last four types of motion are quantified and found to be reduced in the presence of an {alpha}vß3 integrin inhibitor. These dynamic cell motility data result in new hypotheses regarding primordial endothelial cell behavior during embryonic vasculogenesis.

Key words: Vasculogenesis, Endothelial cells, {alpha}vß3 integrin, Time-lapse, Computational biology, Quail


Related articles in Development:

Cell dynamics of vasculogenesis

Development 2004 131: e1205. [Full Text]  



This article has been cited by other articles:


Home page
 Biophys. JHome page
A. Szabo, E. Mehes, E. Kosa, and A. Czirok
Multicellular Sprouting In Vitro
Biophys. J., September 15, 2008; 95(6): 2702 - 2710.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Murga, O. Fernandez-Capetillo, and G. Tosato
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
Blood, March 1, 2005; 105(5): 1992 - 1999.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004