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First published online 14 July 2004
doi: 10.1242/dev.01264

Development 131, 3871-3883 (2004)
Published by The Company of Biologists 2004
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Conditional ß1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system

Thomas Pietri1,*, Olivier Eder1, Marie Anne Breau1, Piotr Topilko2, Martine Blanche1, Cord Brakebusch3, Reinhard Fässler3, Jean-Paul Thiery1 and Sylvie Dufour1,{dagger}

1 UMR144, CNRS – Institut Curie, 26, rue d'Ulm, 75248 Paris Cedex 05, France
2 U 368, INSERM – Ecole Normale Supérieure, 46, rue d'Ulm 75230 Paris Cedex 05, France
3 Max Planck Institute of Biochemistry, Department of Molecular Medicine, Martinsried, 82152, Germany

{dagger} Author for correspondence (e-mail: sylvie.dufour{at}curie.fr)

Accepted 30 April 2004

Integrins are transmembrane receptors that are known to interact with the extracellular matrix and to be required for migration, proliferation, differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the ß1-integrin gene to analyse the role of ß1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death within a month of birth. The loss of ß1-integrins from the embryo delayed the migration of Schwann cells along axons and induced multiple defects in spinal nerve arborisation and morphology. There was an almost complete absence of Schwann cells and sensory axon segregation and defective maturation in neuromuscular synaptogenesis. Thus, ß1-integrins are important for the control of embryonic and postnatal peripheral nervous system development.

Key words: Integrin, Peripheral nervous system, Neural crest cells, Conditional knockout




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