spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 23 March 2005
doi: 10.1242/dev.01796

Development 132, 2115-2124 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.01796v1
132/9/2115    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bok, J.
Right arrow Articles by Wu, D. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bok, J.
Right arrow Articles by Wu, D. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear

Jinwoong Bok1, Marianne Bronner-Fraser2 and Doris K. Wu1,*

1 National Institute on Deafness and other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
2 Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA

* Author for correspondence (e-mail: wud{at}nidcd.nih.gov)

Accepted 18 February 2005

An early and crucial event in vertebrate inner ear development is the acquisition of axial identities that in turn dictate the positions of all subsequent inner ear components. Here, we focus on the role of the hindbrain in establishment of inner ear axes and show that axial specification occurs well after otic placode formation in chicken. Anteroposterior (AP) rotation of the hindbrain prior to specification of this axis does not affect the normal AP orientation and morphogenesis of the inner ear. By contrast, reversing the dorsoventral (DV) axis of the hindbrain results in changing the DV axial identity of the inner ear. Expression patterns of several ventrally expressed otic genes such as NeuroD, Lunatic fringe (Lfng) and Six1 are shifted dorsally, whereas the expression pattern of a normally dorsal-specific gene, Gbx2, is abolished. Removing the source of Sonic Hedgehog (SHH) by ablating the floor plate and/or notochord, or inhibiting SHH function using an antibody that blocks SHH bioactivity results in loss of ventral inner ear structures. Our results indicate that SHH, together with other signals from the hindbrain, are important for patterning the ventral axis of the inner ear. Taken together, our studies suggest that tissue(s) other than the hindbrain confer AP axial information whereas signals from the hindbrain are necessary and sufficient for the DV axial patterning of the inner ear.

Key words: Inner ear, Axis, Axial specification, Induction, Hindbrain, Rhombomere, Sonic hedgehog, SHH, Chicken


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

A rotating view of inner ear patterning

Development 2005 132: e902. [Full Text]  

A rotating view of inner ear patterning

Development 2005 132: e902. [Full Text]  



This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Lin, L. Feng, Y. Hamajima, M. Komori, T. C. Burns, S. Fukudome, J. Anderson, D. Wang, C. M. Verfaillie, and W. C. Low
Directed differentiation of mouse cochlear neural progenitors in vitro
Am J Physiol Cell Physiol, March 1, 2009; 296(3): C441 - C452.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. C. Driver, S. P. Pryor, P. Hill, J. Turner, U. Ruther, L. G. Biesecker, A. J. Griffith, and M. W. Kelley
Hedgehog Signaling Regulates Sensory Cell Formation and Auditory Function in Mice and Humans
J. Neurosci., July 16, 2008; 28(29): 7350 - 7358.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
Development, October 15, 2007; 134(20): 3615 - 3625.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. M. Bosley, M. A. Salih, I. A. Alorainy, D. T. Oystreck, M. Nester, K. K. Abu-Amero, M. A. Tischfield, and E. C. Engle
Clinical characterization of the HOXA1 syndrome BSAS variant
Neurology, September 18, 2007; 69(12): 1245 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Daudet, L. Ariza-McNaughton, and J. Lewis
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
Development, June 15, 2007; 134(12): 2369 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Bok, D. K. Dolson, P. Hill, U. Ruther, D. J. Epstein, and D. K. Wu
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
Development, May 1, 2007; 134(9): 1713 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Ohyama, O. A. Mohamed, M. M. Taketo, D. Dufort, and A. K. Groves
Wnt signals mediate a fate decision between otic placode and epidermis
Development, March 1, 2006; 133(5): 865 - 875.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005