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First published online 3 May 2006
doi: 10.1242/dev.02384

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The left-right axis in the mouse: from origin to morphology

Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan.

^* Author for correspondence (e-mail: hamada{at}fbs.osaka-u.ac.jp)

SUMMARY

The past decade or so has seen rapid progress in our understanding of how left-right (LR) asymmetry is generated in vertebrate embryos. However, many important questions about this process remain unanswered. Although a leftward flow of extra-embryonic fluid in the node cavity (nodal flow) is likely to be the symmetry-breaking event, at least in the mouse embryo, it is not yet known how this flow functions or how the asymmetric signal generated in the node is transferred to the lateral plate. The final step in left-right patterning – translation of the asymmetric signal into morphology – is also little understood.

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