QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 30 May 2006
doi: 10.1242/dev.02427

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: dev.02427v1 133/13/2539    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mao, Y. Articles by Irvine, K. D. Search for Related Content PubMed PubMed Citation Articles by Mao, Y. Articles by Irvine, K. D.

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

Yaopan Mao^1,*, Cordelia Rauskolb^2,*, Eunjoo Cho^1,, Wei-Li Hu^3,, Heather Hayter³, Ginny Minihan³, Flora N. Katz^3, and Kenneth D. Irvine^1,¶

¹ Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA.
² Waksman Institute, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA.
³ Department of Biology, Texas A&M University, College Station, TX 77843-3258, USA.

^¶ Author for correspondence (e-mail: irvine{at}waksman.rutgers.edu)

Accepted 4 May 2006

The dachs gene was first identified almost a century ago based on its requirements for appendage growth, but has been relatively little studied. Here, we describe the phenotypes of strong dachs mutations, report the cloning of the dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings. dachs encodes an unconventional myosin that preferentially localizes to the membrane of imaginal disc cells. dachs mutations suppress the effects of fat mutations on gene expression, cell affinity and growth in imaginal discs. Dachs protein localization is influenced by Fat, Four-jointed and Dachsous, consistent with its genetic placement downstream of fat. However, dachs mutations have only mild tissue polarity phenotypes, and only partially suppress the tissue polarity defects of fat mutants. Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development.

Key words: Dachs, Myosin, Leg, Wing, fat, Growth, Protocadherin, Drosophila

This article has been cited by other articles:

				M. Willecke, F. Hamaratoglu, L. Sansores-Garcia, C. Tao, and G. Halder From the Cover: Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation PNAS, September 30, 2008; 105(39): 14897 - 14902. [Abstract] [Full Text] [PDF]

				B. V. V. G. Reddy and K. D. Irvine The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation Development, September 1, 2008; 135(17): 2827 - 2838. [Abstract] [Full Text] [PDF]

				Y. Feng and K. D. Irvine Fat and Expanded act in parallel to regulate growth through Warts PNAS, December 18, 2007; 104(51): 20362 - 20367. [Abstract] [Full Text] [PDF]

				D. Pan Hippo signaling in organ size control Genes & Dev., April 15, 2007; 21(8): 886 - 897. [Abstract] [Full Text] [PDF]

				F. Yin and D. Pan Fat Flies Expanded the Hippo Pathway: A Matter of Size Control Sci. Signal., April 3, 2007; 2007(380): pe12 - pe12. [Abstract] [Full Text] [PDF]