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First published online 4 October 2006
doi: 10.1242/dev.02593

Development 133, 4145-4149 (2006)
Published by The Company of Biologists 2006
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Research Report

Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila

Catarina Bras-Pereira1,2, Jose Bessa1 and Fernando Casares1,3,*

1 CABD-Andalusian Centre for Developmental Biology, UPO-CSIC, Sevilla 41013, Spain.
2 PDBEB, University of Coimbra, Portugal.
3 IBMC, Porto 4150-180, Portugal.

* Author for correspondence (e-mail: fcasfer{at}upo.es)

Accepted 24 August 2006

SUMMARY

Although many of the factors responsible for conferring identity to the eye field in Drosophila have been identified, much less is known about how the expression of the retinal `trigger', the signaling molecule Hedgehog, is controlled. Here, we show that the co-expression of the conserved odd-skipped family genes at the posterior margin of the eye field is required to activate hedgehog expression and thereby the onset of retinogenesis. The fly Wnt1 homologue wingless represses the odd-skipped genes drm and odd along the anterior margin and, in this manner, spatially restricts the extent of retinal differentiation within the eye field.

Key words: Retinal differentiation, Eye, Drosophila, odd genes, Hedgehog, wingless




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