|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 26 January 2006
doi: 10.1242/dev.02257
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Brain Function, National Institute of Genetics, Graduate
University for Advanced Studies (SOKENDAI), Yata 1111, Mishima 411-8540,
Japan.
2 PREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama,
Japan.
* Author for correspondence (e-mail: tathirat{at}lab.nig.ac.jp)
Accepted 16 December 2005
In the developing nervous system, functional neural networks are constructed with intricate coordination of neuronal migrations and axonal projections. We have previously reported a ventral tangential migration of a special type of cortical neurons, lot cells, in the mouse embryo. These neurons originate from the ventricular zone of the entire neocortex, tangentially migrate in the surface layer of the neocortex into the ventral direction, align in the future pathway of the lateral olfactory tract (LOT) and eventually guide the projection of LOT axons. In this study, we developed an organotypic culture system to investigate the regulation of this cell migration in the developing telencephalon. Our data show that the neocortex contains the signals that direct lot cells ventrally, that the ganglionic eminence excludes lot cells by repelling the migration and that lot cells are attracted to netrin 1, an axon guidance factor. Furthermore, we demonstrate that mutations in the genes encoding netrin 1 and its functional receptor Dcc lead to inappropriate distribution of lot cells and subsequent partial disruption of LOT projection. These results suggest that netrin 1 regulates the migration of lot cells and LOT projections, possibly by ensuring the correct distribution of these guidepost neurons.
Key words: Netrin 1, Ventral tangential migration, Lateral olfactory tract, Guidepost neuron, Lot cells, Mouse
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M.-A. Renault, J. Roncalli, J. Tongers, S. Misener, T. Thorne, K. Jujo, A. Ito, T. Clarke, C. Fung, M. Millay, et al. The Hedgehog Transcription Factor Gli3 Modulates Angiogenesis Circ. Res., October 9, 2009; 105(8): 818 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hagiyama, N. Ichiyanagi, K. B. Kimura, Y. Murakami, and A. Ito Expression of a Soluble Isoform of Cell Adhesion Molecule 1 in the Brain and Its Involvement in Directional Neurite Outgrowth Am. J. Pathol., June 1, 2009; 174(6): 2278 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Garcia-Moreno, L. Lopez-Mascaraque, and J. A. de Carlos Early Telencephalic Migration Topographically Converging in the Olfactory Cortex Cereb Cortex, June 1, 2008; 18(6): 1239 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ito, T. Kawasaki, S. Takashima, I. Matsuda, A. Aiba, and T. Hirata Semaphorin 3F Confines Ventral Tangential Migration of Lateral Olfactory Tract Neurons onto the Telencephalon Surface J. Neurosci., April 23, 2008; 28(17): 4414 - 4422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fouquet, T. Di Meglio, L. Ma, T. Kawasaki, H. Long, T. Hirata, M. Tessier-Lavigne, A. Chedotal, and K. T. Nguyen-Ba-Charvet Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract J. Neurosci., March 14, 2007; 27(11): 3037 - 3045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nomura, J. Holmberg, J. Frisen, and N. Osumi Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5 Development, April 1, 2006; 133(7): 1335 - 1345. [Abstract] [Full Text] [PDF]
|
|
