spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 1 February 2006
doi: 10.1242/dev.02245

Development 133, 913-923 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.02245v1
133/5/913    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jadhav, A. P.
Right arrow Articles by Cepko, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jadhav, A. P.
Right arrow Articles by Cepko, C. L.

Notch 1 inhibits photoreceptor production in the developing mammalian retina

Ashutosh P. Jadhav1, Heather A. Mason2 and Constance L. Cepko1,*

1 Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
2 Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA.

* Author for correspondence (e-mail: cepko{at}genetics.med.harvard.edu)

Accepted 13 December 2005

The transmembrane receptor Notch1 plays a role in development and homeostasis in vertebrates and invertebrates. The mammalian retina is an excellent tissue in which to dissect the precise role of Notch signaling in regulating cell fate and proliferation. However, a systematic analysis has been limited by the early embryonic lethality of Notch1-null mice. Here, Notch1 was conditionally removed from the murine retina either early or late in development. Removal of Notch1 early led to a reduction in the size of the retina as well as aberrant morphology. A decrease in the number of progenitor cells and premature neurogenesis accounted for the reduction in size. Unexpectedly, ablation of Notch1 in early progenitor cells led to enhanced cone photoreceptor production, and ablation of Notch1 at later points led to an almost exclusive production of rod photoreceptor cells. These data suggest that Notch1 not only maintains the progenitor state, but is required to inhibit the photoreceptor fate. These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type.

Key words: Neural development, Retina, Cell fate, Notch, Photoreceptor




This article has been cited by other articles:


Home page
 DevelopmentHome page
E. Cau, A. Quillien, and P. Blader
Notch resolves mixed neural identities in the zebrafish epiphysis
Development, July 15, 2008; 135(14): 2391 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. J. Breunig, J. Silbereis, F. M. Vaccarino, N. Sestan, and P. Rakic
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
PNAS, December 18, 2007; 104(51): 20558 - 20563.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
G. N. Nikopoulos, M. Duarte, C. J. Kubu, S. Bellum, R. Friesel, T. Maciag, I. Prudovsky, and J. M. Verdi
Soluble Jagged1 Attenuates Lateral Inhibition, Allowing for the Clonal Expansion of Neural Crest Stem Cells
Stem Cells, December 1, 2007; 25(12): 3133 - 3142.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Bhattacharya, A. Das, K. Mallya, and I. Ahmad
Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling
J. Cell Sci., August 1, 2007; 120(15): 2652 - 2662.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Corbo, C. A. Myers, K. A. Lawrence, A. P. Jadhav, and C. L. Cepko
A typology of photoreceptor gene expression patterns in the mouse
PNAS, July 17, 2007; 104(29): 12069 - 12074.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Shin, J. Poling, H.-C. Park, and B. Appel
Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish
Development, May 15, 2007; 134(10): 1911 - 1920.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Vooijs, C.-T. Ong, B. Hadland, S. Huppert, Z. Liu, J. Korving, M. van den Born, T. Stappenbeck, Y. Wu, H. Clevers, et al.
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
Development, February 1, 2007; 134(3): 535 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. P. Jadhav, S.-H. Cho, and C. L. Cepko
Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property
PNAS, December 12, 2006; 103(50): 18998 - 19003.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Stahl, C. Ge, S. Shi, R. G. Pestell, and P. Stanley
Notch1-Induced Transformation of RKE-1 Cells Requires Up-regulation of Cyclin D1.
Cancer Res., August 1, 2006; 66(15): 7562 - 7570.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
O. V. Taranova, S. T. Magness, B. M. Fagan, Y. Wu, N. Surzenko, S. R. Hutton, and L. H. Pevny
SOX2 is a dose-dependent regulator of retinal neural progenitor competence.
Genes & Dev., May 1, 2006; 20(9): 1187 - 1202.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006