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First published online 15 March 2006
doi: 10.1242/dev.02318

Development 133, 1467-1475 (2006)
Published by The Company of Biologists 2006
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Drosophila Ik2, a member of the I{kappa}B kinase family, is required for mRNA localization during oogenesis

Risa S. Shapiro1,2 and Kathryn V. Anderson1,*

1 Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.
2 Biochemistry, Cell and Molecular Biology Program, Weill Graduate School of Medical Sciences, Cornell University, 445 East 69th Street, New York, NY 10021, USA.

* Author for correspondence (e-mail: k-anderson{at}ski.mskcc.org)

Accepted 9 February 2006

In both Drosophila and mammals, I{kappa}B kinases (IKKs) regulate the activity of Rel/NF-{kappa}B transcription factors by targeting their inhibitory partner proteins, I{kappa}Bs, for degradation. We identified mutations in ik2, the gene that encodes one of two Drosophila IKKs, and found that the gene is essential for viability. During oogenesis, ik2 is required in an NF-{kappa}B-independent process that is essential for the localization of oskar and gurken mRNAs; as a result, females that lack ik2 in the germline produce embryos that are both bicaudal and ventralized. The abnormal RNA localization in ik2 mutant oocytes can be attributed to defects in the organization of microtubule minus-ends. In addition, both mutant oocytes and mutant escaper adults have abnormalities in the organization of the actin cytoskeleton. These data suggest that this I{kappa}B kinase has an NF-{kappa}B-independent role in mRNA localization and helps to link microtubule minus-ends to the oocyte cortex, a novel function of the IKK family.

Key words: ik2, I{kappa}B kinases, mRNA localization, Oogenesis, Dynein-based transport, oskar, gurken


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