spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 24 October 2007
doi: 10.1242/dev.008367

Development 134, 4131-4140 (2007)
Published by The Company of Biologists 2007
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.008367v1
134/23/4131    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Potthoff, M. J.
Right arrow Articles by Olson, E. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Potthoff, M. J.
Right arrow Articles by Olson, E. N.

Review

MEF2: a central regulator of diverse developmental programs

Matthew J. Potthoff and Eric N. Olson*

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

* Author for correspondence (e-mail: eric.olson{at}utsouthwestern.edu)

SUMMARY

The myocyte enhancer factor 2 (MEF2) transcription factor acts as a lynchpin in the transcriptional circuits that control cell differentiation and organogenesis. The spectrum of genes activated by MEF2 in different cell types depends on extracellular signaling and on co-factor interactions that modulate MEF2 activity. Recent studies have revealed MEF2 to form an intimate partnership with class IIa histone deacetylases, which together function as a point of convergence of multiple epigenetic regulatory mechanisms. We review the myriad roles of MEF2 in development and the mechanisms through which it couples developmental, physiological and pathological signals with programs of cell-specific transcription.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Khiem, J. G. Cyster, J. J. Schwarz, and B. L. Black
A p38 MAPK-MEF2C pathway regulates B-cell proliferation
PNAS, November 4, 2008; 105(44): 17067 - 17072.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
F. Fazi and C. Nervi
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
Cardiovasc Res, September 1, 2008; 79(4): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. C. Barbosa, M.-S. Kim, M. Ertunc, M. Adachi, E. D. Nelson, J. McAnally, J. A. Richardson, E. T. Kavalali, L. M. Monteggia, R. Bassel-Duby, et al.
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
PNAS, July 8, 2008; 105(27): 9391 - 9396.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wang, X. Li, M. Parra, E. Verdin, R. Bassel-Duby, and E. N. Olson
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7
PNAS, June 3, 2008; 105(22): 7738 - 7743.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M.-S. Kim, J. Fielitz, J. McAnally, J. M. Shelton, D. D. Lemon, T. A. McKinsey, J. A. Richardson, R. Bassel-Duby, and E. N. Olson
Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance
Mol. Cell. Biol., June 1, 2008; 28(11): 3600 - 3609.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Liu, A. H. Williams, Y. Kim, J. McAnally, S. Bezprozvannaya, L. B. Sutherland, J. A. Richardson, R. Bassel-Duby, and E. N. Olson
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
PNAS, December 26, 2007; 104(52): 20844 - 20849.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007