QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 21 December 2006
doi: 10.1242/dev.02770

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: dev.02770v1 134/3/427    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Murtaugh, L. C. Search for Related Content PubMed PubMed Citation Articles by Murtaugh, L. C. Social Bookmarking                         What's this?

Pancreas and beta-cell development: from the actual to the possible

University of Utah, Department of Human Genetics, 15 N. 2030 E. Room 2100, Salt Lake City, UT 84112, USA.

e-mail: murtaugh{at}genetics.utah.edu

SUMMARY

The development of insulin-producing pancreatic beta (ß)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate ß-cells. Postnatally, ß-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of ß-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. S. Kang, Y.-S. Kim, G. ZeRuth, J. Y. Beak, K. Gerrish, G. Kilic, B. Sosa-Pineda, J. Jensen, J. Foley, and A. M. Jetten Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic {beta}-Cell Development and Insulin Gene Expression Mol. Cell. Biol., December 15, 2009; 29(24): 6366 - 6379. [Abstract] [Full Text] [PDF]

				K. R. Anderson, C. A. Torres, K. Solomon, T. C. Becker, C. B. Newgard, C. V. Wright, J. Hagman, and L. Sussel Cooperative Transcriptional Regulation of the Essential Pancreatic Islet Gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3 J. Biol. Chem., November 6, 2009; 284(45): 31236 - 31248. [Abstract] [Full Text] [PDF]

				A. Du, C. S. Hunter, J. Murray, D. Noble, C.-L. Cai, S. M. Evans, R. Stein, and C. L. May Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas Diabetes, September 1, 2009; 58(9): 2059 - 2069. [Abstract] [Full Text] [PDF]

				J. F. Wang and D. J Hill Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas J. Endocrinol., April 1, 2009; 201(1): 15 - 25. [Abstract] [Full Text] [PDF]

				T. G. Deering, T. Ogihara, A. P. Trace, B. Maier, and R. G. Mirmira Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes Diabetes, January 1, 2009; 58(1): 185 - 193. [Abstract] [Full Text] [PDF]

				N. Gao, J. LeLay, M. Z. Vatamaniuk, S. Rieck, J. R. Friedman, and K. H. Kaestner Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development Genes & Dev., December 15, 2008; 22(24): 3435 - 3448. [Abstract] [Full Text] [PDF]

				K. S. Zaret and M. Grompe Generation and Regeneration of Cells of the Liver and Pancreas Science, December 5, 2008; 322(5907): 1490 - 1494. [Abstract] [Full Text] [PDF]

				Q. Zhou and D.A. Melton Pathways to New {beta} Cells Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.72.002v1. [Abstract] [PDF]

				Y. Jiang, W. Nishimura, D. Devor-Henneman, D. Kusewitt, H. Wang, M. P. Holloway, T. Dohi, E. Sabo, M. L. Robinson, D. C. Altieri, et al. Postnatal Expansion of the Pancreatic {beta}-Cell Mass Is Dependent on Survivin Diabetes, October 1, 2008; 57(10): 2718 - 2727. [Abstract] [Full Text] [PDF]

				P. J King, L. Guasti, and E. Laufer Hedgehog signalling in endocrine development and disease J. Endocrinol., September 1, 2008; 198(3): 439 - 450. [Abstract] [Full Text] [PDF]

				N. Nekrep, J. Wang, T. Miyatsuka, and M. S. German Signals from the neural crest regulate beta-cell mass in the pancreas Development, June 15, 2008; 135(12): 2151 - 2160. [Abstract] [Full Text] [PDF]

				T. Yano, Z. Liu, J. Donovan, M. K. Thomas, and J. F. Habener Stromal Cell Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic {beta}-Cell Survival by Activation of the Prosurvival Kinase Akt Diabetes, December 1, 2007; 56(12): 2946 - 2957. [Abstract] [Full Text] [PDF]

				R. Kageyama, T. Ohtsuka, and T. Kobayashi The Hes gene family: repressors and oscillators that orchestrate embryogenesis Development, April 1, 2007; 134(7): 1243 - 1251. [Abstract] [Full Text] [PDF]