QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 3 July 2008
doi: 10.1242/dev.022178

This Article Figures Only Full Text Full Text (PDF) Supplementary Material A corrigendum has been published A corrigendum has been published OA All Versions of this Article: dev.022178v1 135/15/2615    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Honjo, Y. Articles by Eisen, J. S. Search for Related Content PubMed PubMed Citation Articles by Honjo, Y. Articles by Eisen, J. S. Social Bookmarking                         What's this?

Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons

Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA.

^* Author for correspondence (e-mail: eisen{at}uoneuro.uoregon.edu)

Accepted 11 June 2008

Dorsal root ganglia (DRGs) arise from trunk neural crest cells that emerge from the dorsal neuroepithelium and coalesce into segmental streams that migrate ventrally along the developing somites. Proper formation of DRGs involves not only normal trunk neural crest migration, but also the ability of DRG progenitors to pause at a particular target location where they can receive DRG-promoting signals. In mammalian embryos, a receptor tyrosine kinase proto-oncogene, ErbB3, is required for proper trunk neural crest migration. Here, we show that in zebrafish mutants lacking ErbB3 function, neural crest cells do not pause at the location where DRGs normally form and DRG neurons are not generated. We also show that these mutants lack trunk neural crest-derived sympathetic neurons, but that cranial neural crest-derived enteric neurons appear normal. We isolated three genes encoding neuregulins, ErbB3 ligands, and show that two neuregulins function together in zebrafish trunk neural crest cell migration and in DRG formation. Together, our results suggest that ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells.

Key words: ErbB2, ErbB3, Neuregulin, Dorsal root ganglion, Neural crest migration, Zebrafish

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. D. Wood, F. Bonath, S. Kumar, C. A. Ross, and V. T. Cunliffe Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain Hum. Mol. Genet., February 1, 2009; 18(3): 391 - 404. [Abstract] [Full Text] [PDF]

				H. F. McGraw, A. Nechiporuk, and D. W. Raible Zebrafish Dorsal Root Ganglia Neural Precursor Cells Adopt a Glial Fate in the Absence of Neurogenin1 J. Neurosci., November 19, 2008; 28(47): 12558 - 12569. [Abstract] [Full Text] [PDF]

				E. H. Budi, L. B. Patterson, and D. M. Parichy Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation Development, August 1, 2008; 135(15): 2603 - 2614. [Abstract] [Full Text] [PDF]