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First published online 11 September 2008
doi: 10.1242/dev.021071

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Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development

Jozef Mravec^1,2, Martin Kube^3,4, Agnieszka Bielach^1,2, Vassilena Gaykova², Jan Petráek^3,4, Petr Skpa^3,4, Suresh Chand², Eva Benková^1,2, Eva Zaímalová³ and Jií Friml^1,2,*

¹ Department of Plant Systems Biology, VIB, and Department of Molecular Genetics, Ghent University, 9052 Gent, Belgium.
² Center for Plant Molecular Biology (ZMBP), University of Tübingen, D-72076 Tübingen, Germany.
³ Institute for Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojová 263, 165 02 Praha 6, Czech Republic.
⁴ Department of Plant Physiology, Faculty of Science, Charles University, Vininá 5, 128 44 Praha 2, Czech Republic.

^* Author for correspondence (e-mail: jiri.friml{at}psb.ugent.be)

Accepted 20 August 2008

The signalling molecule auxin controls plant morphogenesis via its activity gradients, which are produced by intercellular auxin transport. Cellular auxin efflux is the rate-limiting step in this process and depends on PIN and phosphoglycoprotein (PGP) auxin transporters. Mutual roles for these proteins in auxin transport are unclear, as is the significance of their interactions for plant development. Here, we have analysed the importance of the functional interaction between PIN- and PGP-dependent auxin transport in development. We show by analysis of inducible overexpression lines that PINs and PGPs define distinct auxin transport mechanisms: both mediate auxin efflux but they play diverse developmental roles. Components of both systems are expressed during embryogenesis, organogenesis and tropisms, and they interact genetically in both synergistic and antagonistic fashions. A concerted action of PIN- and PGP-dependent efflux systems is required for asymmetric auxin distribution during these processes. We propose a model in which PGP-mediated efflux controls auxin levels in auxin channel-forming cells and, thus, auxin availability for PIN-dependent vectorial auxin movement.

Key words: PGP, PIN, Auxin transport, Embryogenesis, Organogenesis, Tropisms

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