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First published online 2 January 2008
doi: 10.1242/dev.016121

Development 135, 533-540 (2008)
Published by The Company of Biologists 2008
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Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary

Lourdes López-Onieva, Ana Fernández-Miñán* and Acaimo González-Reyes{dagger}

Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Carretera de Utrera km 1, 41013 Sevilla, Spain.

{dagger} Author for correspondence (e-mail: agonrey{at}upo.es)

Accepted 13 November 2007

The existence of specialised regulatory microenvironments or niches that sustain stable stem cell populations is well documented in many tissues. However, the specific mechanisms by which niche support (or stromal) cells govern stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely, ectopic Jak/Stat activation in support cells induces stem cell tumours, implying the presence of a signal relay between the stromal compartment and the stem cell population. We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. Our results provide strong evidence for a model in which Jak/Stat signalling in somatic support cells regulates dpp transcription to define niche size and to maintain the adjacent germline stem cells in an undifferentiated state.

Key words: Jak/Stat, Germline stem cells, Niche signalling, BMP, Drosophila oogenesis


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Development 2008 135: e305. [Full Text]  



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© The Company of Biologists Ltd 2008