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First published online January 23, 2009
doi: 10.1242/10.1242/dev.020867
Review |
1 Massachusetts General Hospital Cancer Center and Center for Regenerative
Medicine, Department of Stem Cell and Regenerative Biology, Harvard Stem Cell
Institute, Harvard University, 185 Cambridge Street, Boston, MA 02114,
USA.
2 University of California Los Angeles, David Geffen School of Medicine,
Department of Biological Chemistry, Jonsson Comprehensive Cancer Center,
Molecular Biology Institute, Eli and Edythe Broad Center of Regenerative
Medicine and Stem Cell Research, 615 Charles E. Young Drive South, BSRB 390D,
Los Angeles, CA 90024, USA.
e-mails: khochedlinger{at}helix.mgh.harvard.edu; kplath{at}mednet.ucla.edu
SUMMARY
The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a unique platform to dissect the molecular mechanisms that underlie epigenetic reprogramming. Moreover, iPS cells can teach us about principles of normal development and disease, and might ultimately facilitate the treatment of patients by custom-tailored cell therapy.
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