spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 28 Feb 2007
doi: 10.1242/dev.000786

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.000786v1
134/7/1243    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kageyama, R.
Right arrow Articles by Kobayashi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kageyama, R.
Right arrow Articles by Kobayashi, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Primer

The Hes gene family: repressors and oscillators that orchestrate embryogenesis


Ryoichiro Kageyama*, Toshiyuki Ohtsuka, and Taeko Kobayashi
* Author for correspondence (e-mail: rkageyam{at}virus.kyoto-u.ac.jp)

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. Hes genes also display an oscillatory expression pattern and control the timing of biological events, such as somite segmentation. Many aspects of Hes expression are regulated by Notch signaling, which mediates cell-cell communication. This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
Y. Muroyama and T. Saito
Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch
Development, December 1, 2009; 136(23): 3889 - 3893.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Scholpp, A. Delogu, J. Gilthorpe, D. Peukert, S. Schindler, and A. Lumsden
Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus
PNAS, November 24, 2009; 106(47): 19895 - 19900.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Kobayashi, H. Mizuno, I. Imayoshi, C. Furusawa, K. Shirahige, and R. Kageyama
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
Genes & Dev., August 15, 2009; 23(16): 1870 - 1875.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Nikolaou, T. Watanabe-Asaka, S. Gerety, M. Distel, R. W. Koster, and D. G. Wilkinson
Lunatic fringe promotes the lateral inhibition of neurogenesis
Development, August 1, 2009; 136(15): 2523 - 2533.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Kubo and S. Nakagawa
Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone
Development, June 1, 2009; 136(11): 1823 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Sakagami, L. Gan, and X.-J. Yang
Distinct Effects of Hedgehog Signaling on Neuronal Fate Specification and Cell Cycle Progression in the Embryonic Mouse Retina
J. Neurosci., May 27, 2009; 29(21): 6932 - 6944.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. S. Tremblay, C. C. Huard, F.-F. Huang, O. Habi, V. Bourdages, G. Levesque, and M. Carreau
The Fanconi Anemia Core Complex Acts as a Transcriptional Co-regulator in Hairy Enhancer of Split 1 Signaling
J. Biol. Chem., May 15, 2009; 284(20): 13384 - 13395.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Zong, A. Panikkar, J. Xu, A. Antoniou, P. Raynaud, F. Lemaigre, and B. Z. Stanger
Notch signaling controls liver development by regulating biliary differentiation
Development, May 15, 2009; 136(10): 1727 - 1739.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Endo, M. A. Antonyak, and R. A. Cerione
Cdc42-mTOR Signaling Pathway Controls Hes5 and Pax6 Expression in Retinoic Acid-dependent Neural Differentiation
J. Biol. Chem., February 20, 2009; 284(8): 5107 - 5118.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Shimizu, T. Kagawa, T. Inoue, A. Nonaka, S. Takada, H. Aburatani, and T. Taga
Stabilized {beta}-Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J{kappa} Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells
Mol. Cell. Biol., December 15, 2008; 28(24): 7427 - 7441.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Tang, J. Brennan, J. Karl, Y. Hamada, L. Raetzman, and B. Capel
Notch signaling maintains Leydig progenitor cells in the mouse testis
Development, November 15, 2008; 135(22): 3745 - 3753.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Hisahara, S. Chiba, H. Matsumoto, M. Tanno, H. Yagi, S. Shimohama, M. Sato, and Y. Horio
From the Cover: Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
PNAS, October 7, 2008; 105(40): 15599 - 15604.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. S. Tremblay, F. F. Huang, O. Habi, C. C. Huard, C. Godin, G. Levesque, and M. Carreau
HES1 is a novel interactor of the Fanconi anemia core complex
Blood, September 1, 2008; 112(5): 2062 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Imayoshi, T. Shimogori, T. Ohtsuka, and R. Kageyama
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
Development, August 1, 2008; 135(15): 2531 - 2541.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
Development, July 1, 2008; 135(13): 2251 - 2261.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. Ben-Yair and C. Kalcheim
Notch and bone morphogenetic protein differentially act on dermomyotome cells to generate endothelium, smooth, and striated muscle
J. Cell Biol., February 6, 2008; 180(3): 607 - 618.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
H. Kokubu, T. Ohtsuka, and R. Kageyama
Mash1 is required for neuroendocrine cell development in the glandular stomach.
Genes Cells, January 1, 2008; 13(1): 41 - 51.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Gridley
Notch signaling in vascular development and physiology
Development, August 1, 2007; 134(15): 2709 - 2718.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
R. Kageyama, S. Yoshiura, Y. Masamizu, and Y. Niwa
Ultradian Oscillators in Somite Segmentation and Other Biological Events
Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 451 - 457.
[Abstract] [PDF]


© The Company of Biologists Ltd 2007