spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 1 Aug 2007
doi: 10.1242/dev.001214


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.001214v1
134/17/3145    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moore, C. A.
Right arrow Articles by Ingham, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, C. A.
Right arrow Articles by Ingham, P. W.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion


Catherine A. Moore, Caroline A. Parkin, Yannick Bidet, and Philip W. Ingham*
* Author for correspondence (e-mail: p.w.ingham{at}sheffield.ac.uk)

Myoblast fusion follows a defined sequence of events that is strikingly similar in vertebrates and invertebrates. Genetic analysis in Drosophila has identified many of the molecules that mediate the different steps in the fusion process; by contrast, the molecular basis of myoblast fusion during vertebrate embryogenesis remains poorly characterised. A key component of the intracellular fusion pathway in Drosophila is the protein encoded by the myoblast city (mbc) gene, a close homologue of the vertebrate protein dedicator of cytokinesis 1 (DOCK1, formerly DOCK180). Using morpholino antisense-oligonucleotide-mediated knockdown of gene activity in the zebrafish embryo, we show that the fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein. In addition, we show that the adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
J. Cell Sci.Home page
S. J. Nowak, P. C. Nahirney, A.-K. Hadjantonakis, and M. K. Baylies
Nap1-mediated actin remodeling is essential for mammalian myoblast fusion
J. Cell Sci., September 15, 2009; 122(18): 3282 - 3293.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
N. L. Quach, S. Biressi, L. F. Reichardt, C. Keller, and T. A. Rando
Focal Adhesion Kinase Signaling Regulates the Expression of Caveolin 3 and {beta}1 Integrin, Genes Essential for Normal Myoblast Fusion
Mol. Biol. Cell, July 15, 2009; 20(14): 3422 - 3435.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
I. A. Johnston, H.-T. Lee, D. J. Macqueen, K. Paranthaman, C. Kawashima, A. Anwar, J. R. Kinghorn, and T. Dalmay
Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes
J. Exp. Biol., June 15, 2009; 212(12): 1781 - 1793.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
E. Vasyutina, B. Martarelli, C. Brakebusch, H. Wende, and C. Birchmeier
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse
PNAS, June 2, 2009; 106(22): 8935 - 8940.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
Y. Hinits, D. P. S. Osborn, and S. M. Hughes
Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
Development, February 1, 2009; 136(3): 403 - 414.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. A. Sanders, D. Ampasala, and M. D. Basson
DOCK5 and DOCK1 Regulate Caco-2 Intestinal Epithelial Cell Spreading and Migration on Collagen IV
J. Biol. Chem., January 2, 2009; 284(1): 27 - 35.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
A. Para, M. Krischke, S. Merlot, Z. Shen, M. Oberholzer, S. Lee, S. Briggs, and R. A. Firtel
Dictyostelium Dock180-related RacGEFs Regulate the Actin Cytoskeleton during Cell Motility
Mol. Biol. Cell, January 1, 2009; 20(2): 699 - 707.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. Laurin, N. Fradet, A. Blangy, A. Hall, K. Vuori, and J.-F. Cote
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
PNAS, October 7, 2008; 105(40): 15446 - 15451.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
H. W. Smith, P. Marra, and C. J. Marshall
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180
J. Cell Biol., August 25, 2008; 182(4): 777 - 790.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
K. V. Pajcini, J. H. Pomerantz, O. Alkan, R. Doyonnas, and H. M. Blau
Myoblasts and macrophages share molecular components that contribute to cell-cell fusion
J. Cell Biol., March 5, 2008; 180(5): 1005 - 1019.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
C. A. Moore, C. A. Parkin, Y. Bidet, and P. W. Ingham
A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion
J. Cell Sci., September 1, 2007; 120(17): e1707 - e1707.
[Full Text]




© The Company of Biologists Ltd 2007