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Development ePress online publication date 6 Jun 2007
doi: 10.1242/dev.003715
Research article
Ftm is a novel basal body protein of cilia involved in Shh signalling
Jeanette Vierkotten,
Renate Dildrop,
Thomas Peters,
Baolin Wang,
and
Ulrich Rüther*
* Author for correspondence (e-mail: ruether{at}uni-duesseldorf.de)
In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.
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