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Development ePress online publication date 4 Jul 2007
doi: 10.1242/dev.004184

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Review

Notch signaling in vascular development and physiology


Thomas Gridley*
* Author for correspondence (e-mail: tom.gridley{at}jax.org)

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include regulation of artery/vein differentiation in endothelial and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during both normal development and tumor angiogenesis, and the differentiation and physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease.




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