spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 31 Oct 2007
doi: 10.1242/dev.005942

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.005942v1
134/23/4255    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hassler, C.
Right arrow Articles by Niehrs, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hassler, C.
Right arrow Articles by Niehrs, C.

Research article

Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling


Christine Hassler, Cristina-Maria Cruciat, Ya-Lin Huang, Sei Kuriyama, Roberto Mayor, and Christof Niehrs*
* Author for correspondence (e-mail: niehrs{at}dkfz-heidelberg.de)

Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting the Wnt co-receptors LRP5/6. Here we show that Krm2 functions independently from Dkks during neural crest (NC) induction in Xenopus. Krm2 is co-expressed with, and regulated by, canonical Wnts. Krm2 is differentially expressed in the NC, and morpholino-mediated Krm2 knockdown inhibits NC induction, which is mimicked by LRP6 depletion. Conversely, krm2 overexpression induces ectopic NC. Kremens bind to LRP6, promote its cell-surface localization and stimulate LRP6 signaling. Furthermore, Krm2 knockdown specifically reduces LRP6 protein levels in NC explants. The results indicate that in the absence of Dkks, Kremens activate Wnt/{beta}-catenin signaling through LRP6.


This article has been cited by other articles:


Home page
 DevelopmentHome page
C.-S. Hong, B.-Y. Park, and J.-P. Saint-Jeannet
Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm
Development, December 1, 2008; 135(23): 3903 - 3910.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Ellwanger, H. Saito, P. Clement-Lacroix, N. Maltry, J. Niedermeyer, W. K. Lee, R. Baron, G. Rawadi, H. Westphal, and C. Niehrs
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
Mol. Cell. Biol., August 1, 2008; 28(15): 4875 - 4882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Semenov, X. Zhang, and X. He
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
J. Biol. Chem., August 1, 2008; 283(31): 21427 - 21432.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
C. S. Cselenyi and E. Lee
Context-Dependent Activation or Inhibition of Wnt-{beta}-Catenin Signaling by Kremen
Sci. Signal., February 26, 2008; 1(8): pe10 - pe10.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007