spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 16 Sep 2003
doi: 10.1242/dev.00758

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.00758v1
130/22/5375    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ulrich, F.
Right arrow Articles by Heisenberg, C.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ulrich, F.
Right arrow Articles by Heisenberg, C.-P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation


Florian Ulrich, Miguel L. Concha, Paul J. Heid, Ed Voss, Sabine Witzel, Henry Roehl, Masazumi Tada, Stephen W. Wilson, Richard J. Adams, David R. Soll, and Carl-Philipp Heisenberg*
* Author for correspondence (e-mail: heisenberg{at}mpi-cbg.de)

During vertebrate gastrulation, highly coordinated cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. In zebrafish, silberblick (slb)/wnt11 regulates normal gastrulation movements by activating a signalling pathway similar to the Frizzled-signalling pathway, which establishes epithelial planar cell polarity (PCP) in Drosophila. However, the cellular mechanisms by which slb/wnt11 functions during zebrafish gastrulation are still unclear. Using high-resolution two-photon confocal imaging followed by computer-assisted reconstruction and motion analysis, we have analysed the movement and morphology of individual cells in three dimensions during the course of gastrulation. We show that in slb-mutant embryos, hypoblast cells within the forming germ ring have slower, less directed migratory movements at the onset of gastrulation. These aberrant cell movements are accompanied by defects in the orientation of cellular processes along the individual movement directions of these cells. We conclude that slb/wnt11-mediated orientation of cellular processes plays a role in facilitating and stabilising movements of hypoblast cells in the germ ring, thereby pointing at a novel function of the slb/wnt11 signalling pathway for the regulation of migratory cell movements at early stages of gastrulation.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cold Spring Harb. Perspect. Biol.Home page
E. K. Vladar, D. Antic, and J. D. Axelrod
Planar Cell Polarity Signaling: The Developing Cell's Compass
Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a002964 - a002964.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Shao, Z.-Z. Liu, C.-D. Wang, H.-Y. Li, C. Carron, H.-W. Zhang, and D.-L. Shi
Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos
Development, June 15, 2009; 136(12): 2121 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Carvalho, J. Stuhmer, J. S. Bois, Y. Kalaidzidis, V. Lecaudey, and C.-P. Heisenberg
Control of convergent yolk syncytial layer nuclear movement in zebrafish
Development, April 15, 2009; 136(8): 1305 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
X. Liu, S. Huang, J. Ma, C. Li, Y. Zhang, and L. Luo
NF-{kappa}B and Snail1a coordinate the cell cycle with gastrulation
J. Cell Biol., March 23, 2009; 184(6): 805 - 815.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kai, C.-P. Heisenberg, and M. Tada
Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation
Development, September 15, 2008; 135(18): 3043 - 3051.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. Yin, M. Kiskowski, P.-A. Pouille, E. Farge, and L. Solnica-Krezel
Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation
J. Cell Biol., January 10, 2008; 180(1): 221 - 232.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. T. Veeman, Y. Nakatani, C. Hendrickson, V. Ericson, C. Lin, and W. C. Smith
chongmague reveals an essential role for laminin-mediated boundary formation in chordate convergence and extension movements
Development, January 1, 2008; 135(1): 33 - 41.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
H. Yamanaka and E. Nishida
Wnt11 stimulation induces polarized accumulation of Dishevelled at apical adherens junctions through Frizzled7
Genes Cells, August 1, 2007; 12(8): 961 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Y. Miyasaka, Y. S. Kida, T. Sato, M. Minami, and T. Ogura
Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
PNAS, July 3, 2007; 104(27): 11274 - 11279.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Witzel, V. Zimyanin, F. Carreira-Barbosa, M. Tada, and C.-P. Heisenberg
Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane
J. Cell Biol., December 4, 2006; 175(5): 791 - 802.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. England, G. B. Blanchard, L. Mahadevan, and R. J. Adams
A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia
Development, December 1, 2006; 133(23): 4613 - 4617.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Satoh, T. Gotoh, Y. Tsunematsu, S. Aizawa, and A. Shimono
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
Development, March 15, 2006; 133(6): 989 - 999.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F. Lin, D. S. Sepich, S. Chen, J. Topczewski, C. Yin, L. Solnica-Krezel, and H. Hamm
Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
J. Cell Biol., June 6, 2005; 169(5): 777 - 787.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. De Calisto, C. Araya, L. Marchant, C. F. Riaz, and R. Mayor
Essential role of non-canonical Wnt signalling in neural crest migration
Development, June 1, 2005; 132(11): 2587 - 2597.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J.-A. Montero, L. Carvalho, M. Wilsch-Brauninger, B. Kilian, C. Mustafa, and C.-P. Heisenberg
Shield formation at the onset of zebrafish gastrulation
Development, March 15, 2005; 132(6): 1187 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. J.B. van den Hoff and A. F.M. Moorman
Wnt, a Driver of Myocardialization?
Circ. Res., February 18, 2005; 96(3): 274 - 276.
[Full Text] [PDF]

Home page
 DevelopmentHome page
C. J. Thorpe and R. T. Moon
nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development
Development, June 15, 2004; 131(12): 2899 - 2909.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003