The fully linked HTML version of this article has now been published.
Development ePress online publication date 24 Sep 2003
doi: 10.1242/dev.00760
Research article
Tgf
signaling acts on a Hox response element to confer specificity and diversity to Hox protein function
Aurélie Grienenberger,
Samir Merabet,
John Manak,
Isabelle Iltis,
Aurélie Fabre,
Hélène Bérenger,
Matthew P. Scott,
Jacques Pradel,
and
Yacine Graba*
* Author for correspondence (e-mail: graba{at}lgpd.univ-mrs.fr)
Hox proteins play fundamental roles in generating pattern diversity during development and evolution, acting in broad domains but controlling localized cell diversification and pattern. Much remains to be learned about how Hox selector proteins generate cell-type diversity. In this study, regulatory specificity was investigated by dissecting the genetic and molecular requirements that allow the Hox protein Abdominal A to activate wingless in only a few cells of its broad expression domain in the Drosophila visceral mesoderm. We show that the Dpp/Tgf
signal controls Abdominal A function, and that Hox protein and signal-activated regulators converge on a wingless enhancer. The signal, acting through Mad and Creb, provides spatial information that subdivides the domain of Abdominal A function through direct combinatorial action, conferring specificity and diversity upon Abdominal A activity.
This article has been cited by other articles:
|
|
|
|
 
T. Hayashi, C. Xu, and R. W. Carthew
Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye
Development,
August 15, 2008;
135(16):
2787 - 2796.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Walsh and S. B. Carroll
Collaboration between Smads and a Hox protein in target gene repression
Development,
October 15, 2007;
134(20):
3585 - 3592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Bondos, X.-X. Tan, and K. S. Matthews
Physical and Genetic Interactions Link Hox Function with Diverse Transcription Factors and Cell Signaling Proteins
Mol. Cell. Proteomics,
May 1, 2006;
5(5):
824 - 834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis
Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability
Nucleic Acids Res.,
August 8, 2005;
33(14):
4475 - 4484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Merabet, J. C.-G. Hombria, N. Hu, J. Pradel, and Y. Graba
Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis
Development,
July 1, 2005;
132(13):
3093 - 3102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Hersh and S. B. Carroll
Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila
Development,
April 1, 2005;
132(7):
1567 - 1577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ebner, C. Cabernard, M. Affolter, and S. Merabet
Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
Development,
April 1, 2005;
132(7):
1591 - 1600.
[Abstract]
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2003
