The fully linked HTML version of this article has now been published.
Development ePress online publication date 1 Oct 2003
doi: 10.1242/dev.00808
Research article
Neural crest development is regulated by the transcription factor Sox9
Martin Cheung
and
James Briscoe*
* Author for correspondence (e-mail: james.briscoe{at}nimr.mrc.ac.uk)
The neural crest is a transient migratory population of stem cells derived from the dorsal neural folds at the border between neural and non-neural ectoderm. Following induction, prospective neural crest cells are segregated within the neuroepithelium and then delaminate from the neural tube and migrate into the periphery, where they generate multiple differentiated cell types. The intrinsic determinants that direct this process are not well defined. Group E Sox genes (Sox8, Sox9 and Sox10) are expressed in the prospective neural crest and Sox9 expression precedes expression of premigratory neural crest markers. Here, we show that group E Sox genes act at two distinct steps in neural crest differentiation. Forced expression of Sox9 promotes neural-crest-like properties in neural tube progenitors at the expense of central nervous system neuronal differentiation. Subsequently, in migratory neural crest cells, SoxE gene expression biases cells towards glial cell and melanocyte fate, and away from neuronal lineages. Although SoxE genes are sufficient to initiate neural crest development they do not efficiently induce the delamination of ectopic neural crest cells from the neural tube consistent with the idea that this event is independently controlled. Together, these data identify a role for group E Sox genes in the initiation of neural crest development and later SoxE genes influence the differentiation pathway adopted by migrating neural crest cells.
This article has been cited by other articles:
|
|
|
|
 
K. Piper Hanley, F. Oakley, S. Sugden, D. I. Wilson, D. A. Mann, and N. A. Hanley
Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis
J. Biol. Chem.,
May 16, 2008;
283(20):
14063 - 14071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Holmberg, E. Hansson, M. Malewicz, M. Sandberg, T. Perlmann, U. Lendahl, and J. Muhr
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Development,
May 15, 2008;
135(10):
1843 - 1851.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Teng, N. A. Mundell, A. Y. Frist, Q. Wang, and P. A. Labosky
Requirement for Foxd3 in the maintenance of neural crest progenitors
Development,
May 1, 2008;
135(9):
1615 - 1624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Reiprich, C. C. Stolt, S. Schreiner, R. Parlato, and M. Wegner
SoxE Proteins Are Differentially Required in Mouse Adrenal Gland Development
Mol. Biol. Cell,
April 1, 2008;
19(4):
1575 - 1586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Finzsch, C. C. Stolt, P. Lommes, and M. Wegner
Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor {alpha} expression
Development,
February 15, 2008;
135(4):
637 - 646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. de Bont, J. M. Kros, M. M.C.J. Passier, R. E. Reddingius, P. A.E. S. Smitt, T. M. Luider, M. L. d. Boer, and R. Pieters
Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis
Neuro-oncol,
January 1, 2008;
10(5):
648 - 660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Ramocki, H. R. Wilkins, S. T. Magness, J. G. Simmons, B. P. Scull, G. H. Lee, K. K. McNaughton, and P. K. Lund
Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+ Tumors, and Regulates Sox9
Endocrinology,
January 1, 2008;
149(1):
261 - 267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Werner, A. Hammer, M. Wahlbuhl, M. R. Bosl, and M. Wegner
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis
Nucleic Acids Res.,
October 8, 2007;
35(19):
6526 - 6538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schreiner, F. Cossais, K. Fischer, S. Scholz, M. R. Bosl, B. Holtmann, M. Sendtner, and M. Wegner
Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
Development,
September 15, 2007;
134(18):
3271 - 3281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Passeron, J. C. Valencia, C. Bertolotto, T. Hoashi, E. Le Pape, K. Takahashi, R. Ballotti, and V. J. Hearing
SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation
PNAS,
August 28, 2007;
104(35):
13984 - 13989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. T. Pankratz, X.-J. Li, T. M. LaVaute, E. A. Lyons, X. Chen, and S.-C. Zhang
Directed Neural Differentiation of Human Embryonic Stem Cells via an Obligated Primitive Anterior Stage
Stem Cells,
June 1, 2007;
25(6):
1511 - 1520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Seymour, K. K. Freude, M. N. Tran, E. E. Mayes, J. Jensen, R. Kist, G. Scherer, and M. Sander
From the Cover: SOX9 is required for maintenance of the pancreatic progenitor cell pool
PNAS,
February 6, 2007;
104(6):
1865 - 1870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Nemetski and L. B. Gardner
Hypoxic Regulation of Id-1 and Activation of the Unfolded Protein Response Are Aberrant in Neuroblastoma
J. Biol. Chem.,
January 5, 2007;
282(1):
240 - 248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. O'Donnell, C.-S. Hong, X. Huang, R. J. Delnicki, and J.-P. Saint-Jeannet
Functional analysis of Sox8 during neural crest development in Xenopus
Development,
October 1, 2006;
133(19):
3817 - 3826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Park, K. Lavine, Y. Mishina, C.-X. Deng, D. M. Ornitz, and K. Choi
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation
Development,
September 1, 2006;
133(17):
3473 - 3484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kellerer, S. Schreiner, C. C. Stolt, S. Scholz, M. R. Bosl, and M. Wegner
Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence
Development,
August 1, 2006;
133(15):
2875 - 2886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Tagariello, R Heller, A Greven, V M Kalscheuer, T Molter, A Rauch, W Kress, and A Winterpacht
Balanced translocation in a patient with craniosynostosis disrupts the SOX6 gene and an evolutionarily conserved non-transcribed region
J. Med. Genet.,
June 1, 2006;
43(6):
534 - 540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sakai, T. Suzuki, N. Osumi, and Y. Wakamatsu
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
Development,
April 1, 2006;
133(7):
1323 - 1333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Miller, F. Rangwala, J. Williams, P. Ackerman, S. Kong, A. G. Jegga, S. Kaiser, B. J. Aronow, S. Frahm, L. Kluwe, et al.
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res.,
March 1, 2006;
66(5):
2584 - 2591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Antonellis, W. R. Bennett, T. R. Menheniott, A. B. Prasad, S.-Q. Lee-Lin, NISC Comparative Sequencing Program, E. D. Green, D. Paisley, R. N. Kelsh, W. J. Pavan, et al.
Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome
Hum. Mol. Genet.,
January 15, 2006;
15(2):
259 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Helms, D. Cordero, and M. D. Tapadia
New insights into craniofacial morphogenesis
Development,
March 1, 2005;
132(5):
851 - 861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev.,
March 1, 2005;
19(5):
626 - 641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-L. Yan, J. Willoughby, D. Liu, J. G. Crump, C. Wilson, C. T. Miller, A. Singer, C. Kimmel, M. Westerfield, and J. H. Postlethwait
A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
Development,
March 1, 2005;
132(5):
1069 - 1083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Burstyn-Cohen, J. Stanleigh, D. Sela-Donenfeld, and C. Kalcheim
Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition
Development,
November 1, 2004;
131(21):
5327 - 5339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Cantrell, S. E. Owens, R. L. Chandler, D. C. Airey, K. M. Bradley, J. R. Smith, and E. M. Southard-Smith
Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease
Hum. Mol. Genet.,
October 1, 2004;
13(19):
2289 - 2301.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Perez-Alcala, M. A. Nieto, and J. A. Barbas
LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest
Development,
September 15, 2004;
131(18):
4455 - 4465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Blache, M. van de Wetering, I. Duluc, C. Domon, P. Berta, J.-N. Freund, H. Clevers, and P. Jay
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
J. Cell Biol.,
July 5, 2004;
166(1):
37 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2003
