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Development ePress online publication date 19 Nov 2003
doi: 10.1242/dev.00866

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Research article: Development and disease

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways


Stéphane Dauger, Alexandre Pattyn, Frédéric Lofaso, Claude Gaultier, Christo Goridis, Jorge Gallego, and Jean-François Brunet*
* Author for correspondence (e-mail: jfbrunet{at}biologie.ens.fr)

We report that the afferent relays of visceral (cardiovascular, digestive and respiratory) reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose), while their central target, the nucleus of the solitary tract, which integrates all visceral information, never forms. These data establish Phox2b as an unusual 'circuit-specific' transcription factor devoted to the formation of autonomic reflex pathways. We also show that Phox2b heterozygous mutants have an altered response to hypoxia and hypercapnia at birth and a decreased tyrosine hydroxylase expression in the petrosal chemosensory neurons, thus providing mechanistic insight into congenital central hypoventilation syndrome, which is associated with heterozygous mutations in PHOX2B.


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