spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 3 Dec 2003
doi: 10.1242/dev.00924

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.00924v1
131/1/143    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hwang, B. J.
Right arrow Articles by Sternberg, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hwang, B. J.
Right arrow Articles by Sternberg, P. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development


Byung Joon Hwang and Paul W. Sternberg*
* Author for correspondence (e-mail: pws{at}its.caltech.edu)

During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3, activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs. Previous studies with lin-3 mutants and transgene expression have revealed that the level of LIN-3 in the AC must be precisely regulated for proper vulval development. To understand how lin-3 expression is achieved in the AC, we identified a 59 bp lin-3 enhancer sufficient to activate lin-3 transcription solely in the AC. The enhancer contains two E-box elements, and one FTZ-F1 nuclear hormone receptor (NHR) binding site that is mutated in a vulvaless mutant, lin-3(e1417). Mutagenesis studies show that both E-boxes and the NHR binding site are necessary to express lin-3 in the AC. In vitro DNA-binding studies and in vivo functional assays indicate that distinct trans-acting factors, including the E-protein/Daughterless homolog HLH-2 and unidentified nuclear hormone receptor(s), are necessary for lin-3 transcription in the AC and thus are involved in vulval development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
T. L. Vrablik, L. Huang, S. E. Lange, and W. Hanna-Rose
Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans
Development, November 1, 2009; 136(21): 3637 - 3646.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. J. Hwang, A. D. Meruelo, and P. W. Sternberg
C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion
Development, February 15, 2007; 134(4): 669 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. V. Sundaram
The love-hate relationship between Ras and Notch
Genes & Dev., August 15, 2005; 19(16): 1825 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Silhankova, M. Jindra, and M. Asahina
Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans
J. Cell Sci., January 1, 2005; 118(1): 223 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Z. Chen, D. J. Eastburn, and M. Han
The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development
Mol. Cell. Biol., September 1, 2004; 24(17): 7345 - 7358.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003