spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 8 Apr 2004
doi: 10.1242/dev.01086

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01086v1
131/9/2205    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stottmann, R. W.
Right arrow Articles by Klingensmith, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stottmann, R. W.
Right arrow Articles by Klingensmith, J.

Research article: Development and disease

BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium


Rolf W. Stottmann, Murim Choi, Yuji Mishina, Erik N. Meyers, and John Klingensmith*
* Author for correspondence (e-mail: kling{at}cellbio.duke.edu)

The neural crest is a multipotent, migratory cell population arising from the border of the neural and surface ectoderm. In mouse, the initial migratory neural crest cells occur at the five-somite stage. Bone morphogenetic proteins (BMPs), particularly BMP2 and BMP4, have been implicated as regulators of neural crest cell induction, maintenance, migration, differentiation and survival. Mouse has three known BMP2/4 type I receptors, of which Bmpr1a is expressed in the neural tube sufficiently early to be involved in neural crest development from the outset; however, earlier roles in other domains obscure its requirement in the neural crest. We have ablated Bmpr1a specifically in the neural crest, beginning at the five-somite stage. We find that most aspects of neural crest development occur normally; suggesting that BMPRIA is unnecessary for many aspects of early neural crest biology. However, mutant embryos display a shortened cardiac outflow tract with defective septation, a process known to require neural crest cells and to be essential for perinatal viability. Surprisingly, these embryos die in mid-gestation from acute heart failure, with reduced proliferation of ventricular myocardium. The myocardial defect may involve reduced BMP signaling in a novel, minor population of neural crest derivatives in the epicardium, a known source of ventricular myocardial proliferation signals. These results demonstrate that BMP2/4 signaling in mammalian neural crest derivatives is essential for outflow tract development and may regulate a crucial proliferation signal for the ventricular myocardium.


This article has been cited by other articles:


Home page
 DevelopmentHome page
J. Zhang, Y. Lin, Y. Zhang, Y. Lan, C. Lin, A. M. Moon, R. J. Schwartz, J. F. Martin, and F. Wang
Frs2{alpha}-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis
Development, November 1, 2008; 135(21): 3611 - 3622.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. J. Park, Y. Watanabe, G. Smyth, S. Miyagawa-Tomita, E. Meyers, J. Klingensmith, T. Camenisch, M. Buckingham, and A. M. Moon
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart
Development, November 1, 2008; 135(21): 3599 - 3610.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Klaus, Y. Saga, M. M. Taketo, E. Tzahor, and W. Birchmeier
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis
PNAS, November 20, 2007; 104(47): 18531 - 18536.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Samanta, G. M. Burke, T. McGuire, A. J. Pisarek, A. Mukhopadhyay, Y. Mishina, and J. A. Kessler
BMPR1a Signaling Determines Numbers of Oligodendrocytes and Calbindin-Expressing Interneurons in the Cortex
J. Neurosci., July 11, 2007; 27(28): 7397 - 7407.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. N. Johnson, L. A. Burnett, J. Sellin, A. Paululat, and S. J. Newfeld
Defective Decapentaplegic Signaling Results in Heart Overgrowth and Reduced Cardiac Output in Drosophila
Genetics, July 1, 2007; 176(3): 1609 - 1624.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. Van de Putte, A. Francis, L. Nelles, L. A. van Grunsven, and D. Huylebroeck
Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome
Hum. Mol. Genet., June 15, 2007; 16(12): 1423 - 1436.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Ai, X. Fu, J. Wang, M.-F. Lu, L. Chen, A. Baldini, W. H. Klein, and J. F. Martin
Canonical Wnt signaling functions in second heart field to promote right ventricular growth
PNAS, May 29, 2007; 104(22): 9319 - 9324.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. van Wijk, A. F.M. Moorman, and M. J.B. van den Hoff
Role of bone morphogenetic proteins in cardiac differentiation
Cardiovasc Res, May 1, 2007; 74(2): 244 - 255.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. David, C. Mallet, S. Mazerbourg, J.-J. Feige, and S. Bailly
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
Blood, March 1, 2007; 109(5): 1953 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Choi, R. W. Stottmann, Y.-P. Yang, E. N. Meyers, and J. Klingensmith
The Bone Morphogenetic Protein Antagonist Noggin Regulates Mammalian Cardiac Morphogenesis
Circ. Res., February 2, 2007; 100(2): 220 - 228.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Park, K. Lavine, Y. Mishina, C.-X. Deng, D. M. Ornitz, and K. Choi
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation
Development, September 1, 2006; 133(17): 3473 - 3484.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Marguerie, F. Bajolle, S. Zaffran, N. A. Brown, C. Dickson, M. E. Buckingham, and R. G. Kelly
Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
Cardiovasc Res, July 1, 2006; 71(1): 50 - 60.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Liu, F. Liu, A. E. Schneider, T. St. Amand, J. A. Epstein, and D. E. Gutstein
Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
Development, May 15, 2006; 133(10): 2063 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Ishii, J. Han, H.-Y. Yen, H. M. Sucov, Y. Chai, and R. E. Maxson Jr
Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
Development, November 15, 2005; 132(22): 4937 - 4950.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh
Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses
J. Biol. Chem., September 16, 2005; 280(37): 32122 - 32132.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Kleber, H.-Y. Lee, H. Wurdak, J. Buchstaller, M. M. Riccomagno, L. M. Ittner, U. Suter, D. J. Epstein, and L. Sommer
Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling
J. Cell Biol., April 25, 2005; 169(2): 309 - 320.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. E. Harrison, R. Berger, S. G. Haworth, R. Tulloh, C. J. Mache, N. W. Morrell, M. A. Aldred, and R. C. Trembath
Transforming Growth Factor-{beta} Receptor Mutations and Pulmonary Arterial Hypertension in Childhood
Circulation, February 1, 2005; 111(4): 435 - 441.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004