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The hair follicle is a model system for studying epithelial-mesenchymal interactions during organogenesis. Although analysis of the epithelial contribution to these interactions has progressed rapidly, the lack of tools to manipulate gene expression in the mesenchymal component, the dermal papilla, has hampered progress towards understanding the contribution of these cells. In this work, Corin was identified in a screen to detect genes specifically expressed in the dermal papilla. It is expressed in the dermal papilla of all pelage hair follicle types from the earliest stages of their formation, but is not expressed elsewhere in the skin. Mutation of the Corin gene reveals that it is not required for morphogenesis of the hair follicle. However, analysis of the 'dirty blonde' phenotype of these mice reveals that the transmembrane protease encoded by Corin plays a critical role in specifying coat color and acts downstream of agouti gene expression as a suppressor of the agouti pathway.
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Development ePress online publication date 5 Dec 2007
doi: 10.1242/dev.011031
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The serine protease Corin is a novel modifier of the agouti pathway
* Author for correspondence (e-mail: bruce.morgan{at}cbrc2.mgh.harvard.edu)
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T. H. Bugge, T. M. Antalis, and Q. Wu
Type II Transmembrane Serine Proteases
J. Biol. Chem.,
August 28, 2009;
284(35):
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R. R. Driskell, A. Giangreco, K. B. Jensen, K. W. Mulder, and F. M. Watt
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
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Corin, atrial natriuretic peptide and hypertension
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P. A. Nigrovic, D. H.D. Gray, T. Jones, J. Hallgren, F. C. Kuo, B. Chaletzky, M. Gurish, D. Mathis, C. Benoist, and D. M. Lee
Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy
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© The Company of Biologists Ltd 2007