spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 5 Dec 2007
doi: 10.1242/dev.011031

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.011031v1
135/2/217    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Enshell-Seijffers, D.
Right arrow Articles by Morgan, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Enshell-Seijffers, D.
Right arrow Articles by Morgan, B. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

The serine protease Corin is a novel modifier of the agouti pathway


David Enshell-Seijffers, Catherine Lindon, and Bruce A. Morgan*
* Author for correspondence (e-mail: bruce.morgan{at}cbrc2.mgh.harvard.edu)

The hair follicle is a model system for studying epithelial-mesenchymal interactions during organogenesis. Although analysis of the epithelial contribution to these interactions has progressed rapidly, the lack of tools to manipulate gene expression in the mesenchymal component, the dermal papilla, has hampered progress towards understanding the contribution of these cells. In this work, Corin was identified in a screen to detect genes specifically expressed in the dermal papilla. It is expressed in the dermal papilla of all pelage hair follicle types from the earliest stages of their formation, but is not expressed elsewhere in the skin. Mutation of the Corin gene reveals that it is not required for morphogenesis of the hair follicle. However, analysis of the 'dirty blonde' phenotype of these mice reveals that the transmembrane protease encoded by Corin plays a critical role in specifying coat color and acts downstream of agouti gene expression as a suppressor of the agouti pathway.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
T. H. Bugge, T. M. Antalis, and Q. Wu
Type II Transmembrane Serine Proteases
J. Biol. Chem., August 28, 2009; 284(35): 23177 - 23181.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. R. Driskell, A. Giangreco, K. B. Jensen, K. W. Mulder, and F. M. Watt
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Development, August 15, 2009; 136(16): 2815 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Y. Zhou, J. Jiang, Y. Cui, and Q. Wu
Corin, atrial natriuretic peptide and hypertension
Nephrol. Dial. Transplant., April 1, 2009; 24(4): 1071 - 1073.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. A. Nigrovic, D. H.D. Gray, T. Jones, J. Hallgren, F. C. Kuo, B. Chaletzky, M. Gurish, D. Mathis, C. Benoist, and D. M. Lee
Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy
Am. J. Pathol., December 1, 2008; 173(6): 1693 - 1701.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007