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Development ePress online publication date 5 May 2004
doi: 10.1242/dev.01141

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Research article

Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling


Martina Nagel, Emilios Tahinci, Karen Symes, and Rudolf Winklbauer*
* Author for correspondence (e-mail: winklbauer{at}zoo.utoronto.ca)

In vertebrates, PDGFA and its receptor, PDGFR{alpha}, are expressed in the early embryo. Impairing their function causes an array of developmental defects, but the underlying target processes that are directly controlled by these factors are not well known. We show that in the Xenopus gastrula, PDGFA/PDGFR{alpha} signaling is required for the directional migration of mesodermal cells on the extracellular matrix of the blastocoel roof. Blocking PDGFR{alpha} function in the mesoderm does not inhibit migration per se, but results in movement that is randomized and no longer directed towards the animal pole. Likewise, compromising PDGFA function in the blastocoel roof substratum abolishes directionality of movement. Overexpression of wild-type PDGFA, or inhibition of PDGFA both lead to randomized migration, disorientation of polarized mesodermal cells, decreased movement towards the animal pole, and reduced head formation and axis elongation. This is consistent with an instructive role for PDGFA in the guidance of mesoderm migration.
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