spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 16 Jun 2004
doi: 10.1242/dev.01203

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01203v1
131/14/3333    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mandler, M.
Right arrow Articles by Neubüser, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mandler, M.
Right arrow Articles by Neubüser, A.

Research article

FGF signaling is required for initiation of feather placode development


Markus Mandler and Annette Neubüser*
* Author for correspondence (e-mail: annette.neubueser{at}biologie.uni-freiburg.de)

Morphogenesis of hairs and feathers is initiated by an as yet unknown dermal signal that induces placode formation in the overlying ectoderm. To determine whether FGF signals are required for this process we over-expressed soluble versions of FGFR1 or FGFR2 in the skin of chicken embryos. This produced a complete failure of feather formation prior to any morphological or molecular signs of placode development. We further show that Fgf10 is expressed in the dermis of nascent feather primordia, and that anti-FGF10 antibodies block feather placode development in skin explants. In addition we show that FGF10 can induce expression of positive and negative regulators of feather development and can induce its own expression under conditions of low BMP signaling. Together these results demonstrate that FGF signaling is required for the initiation of feather placode development and implicate FGF10 as an early dermal signal involved in this process.


This article has been cited by other articles:


Home page
 DevelopmentHome page
B. F. Eames and R. A. Schneider
The genesis of cartilage size and shape during development and evolution
Development, December 1, 2008; 135(23): 3947 - 3958.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Gao, M. C. DeRouen, C.-H. Chen, M. Nguyen, N. T. Nguyen, H. Ido, K. Harada, K. Sekiguchi, B. A. Morgan, J. H. Miner, et al.
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
Genes & Dev., August 1, 2008; 22(15): 2111 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
W. Wu, R. F. Xu, L. Xiao, H. Xu, and G. Gao
Expression of the -Catenin Gene in the Skin of Embryonic Geese During Feather Bud Development
Poult. Sci., January 1, 2008; 87(1): 204 - 211.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. W. Stock, W. R. Jackman, and J. Trapani
Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes
Development, August 15, 2006; 133(16): 3127 - 3137.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. L. Hehr, J. C. Hocking, and S. McFarlane
Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points
Development, August 1, 2005; 132(15): 3371 - 3379.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. F. Eames and R. A. Schneider
Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development
Development, April 1, 2005; 132(7): 1499 - 1509.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004