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Development ePress online publication date 14 Jul 2004
doi: 10.1242/dev.01264

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Research article

Conditional {beta}1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system


Thomas Pietri, Olivier Eder, Marie Anne Breau, Piotr Topilko, Martine Blanche, Cord Brakebusch, Reinhard Fässler, Jean-Paul Thiery, and Sylvie Dufour*
* Author for correspondence (e-mail: sylvie.dufour{at}curie.fr)

Integrins are transmembrane receptors that are known to interact with the extracellular matrix and to be required for migration, proliferation, differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the {beta}1-integrin gene to analyse the role of {beta}1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death within a month of birth. The loss of {beta}1-integrins from the embryo delayed the migration of Schwann cells along axons and induced multiple defects in spinal nerve arborisation and morphology. There was an almost complete absence of Schwann cells and sensory axon segregation and defective maturation in neuromuscular synaptogenesis. Thus, {beta}1-integrins are important for the control of embryonic and postnatal peripheral nervous system development.


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