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Development ePress online publication date 16 Dec 2004
doi: 10.1242/dev.01567

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Research article

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain


Verónica Palma, Daniel A. Lim, Nadia Dahmane, Pilar Sánchez, Thomas C. Brionne, Claudia D. Herzberg, Yorick Gitton, Alan Carleton, Arturo Álvarez-Buylla, and Ariel Ruiz i Altaba*
* Author for correspondence (e-mail: ariel.ruizaltaba{at}medecine.unige.ch)

Sonic hedgehog (Shh) signaling controls many aspects of ontogeny, orchestrating congruent growth and patterning. During brain development, Shh regulates early ventral patterning while later on it is critical for the regulation of precursor proliferation in the dorsal brain, namely in the neocortex, tectum and cerebellum. We have recently shown that Shh also controls the behavior of cells with stem cell properties in the mouse embryonic neocortex, and additional studies have implicated it in the control of cell proliferation in the adult ventral forebrain and in the hippocampus. However, it remains unclear whether it regulates adult stem cell lineages in an equivalent manner. Similarly, it is not known which cells respond to Shh signaling in stem cell niches. Here we demonstrate that Shh is required for cell proliferation in the mouse forebrain's subventricular zone (SVZ) stem cell niche and for the production of new olfactory interneurons in vivo. We identify two populations of Gli1+ Shh signaling responding cells: GFAP+ SVZ stem cells and GFAP- precursors. Consistently, we show that Shh regulates the self-renewal of neurosphere-forming stem cells and that it modulates proliferation of SVZ lineages by acting as a mitogen in cooperation with epidermal growth factor (EGF). Together, our data demonstrate a critical and conserved role of Shh signaling in the regulation of stem cell lineages in the adult mammalian brain, highlight the subventricular stem cell astrocytes and their more abundant derived precursors as in vivo targets of Shh signaling, and demonstrate the requirement for Shh signaling in postnatal and adult neurogenesis.
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Home page
 J. Neurosci.Home page
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[Abstract] [Full Text] [PDF]

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Home page
 Hum Mol GenetHome page
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Hum. Mol. Genet., May 15, 2009; 18(10): 1740 - 1754.
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Home page
 Cancer Res.Home page
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Home page
 Endocr. Rev.Home page
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Home page
 J EndocrinolHome page
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Home page
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Home page
 J. Neurosci.Home page
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[Abstract] [Full Text] [PDF]

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Home page
 aacredbookHome page
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Home page
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Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
Phil Trans R Soc B, January 12, 2008; 363(1489): 123 - 137.
[Abstract] [Full Text] [PDF]

Home page
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J. D. Cahoy, B. Emery, A. Kaushal, L. C. Foo, J. L. Zamanian, K. S. Christopherson, Y. Xing, J. L. Lubischer, P. A. Krieg, S. A. Krupenko, et al.
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J. Neurosci., January 2, 2008; 28(1): 264 - 278.
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Home page
 J. Neurosci.Home page
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J. Neurosci., December 26, 2007; 27(52): 14248 - 14259.
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PNAS, December 11, 2007; 104(50): 19879 - 19884.
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Home page
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L. Wang, Z. G. Zhang, S. R. Gregg, R. L. Zhang, Z. Jiao, Y. LeTourneau, X. Liu, Y. Feng, J. Gerwien, L. Torup, et al.
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J. Biol. Chem., November 2, 2007; 282(44): 32462 - 32470.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
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J. Neurosci., July 25, 2007; 27(30): 7939 - 7953.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. A. Ruzhynsky, K. A. McClellan, J. L. Vanderluit, Y. Jeong, M. Furimsky, D. S. Park, D. J. Epstein, V. A. Wallace, and R. S. Slack
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J. Neurosci., May 30, 2007; 27(22): 5926 - 5935.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Balordi and G. Fishell
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
J. Neurosci., May 30, 2007; 27(22): 5936 - 5947.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. R. Langley and I. J. Fidler
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Endocr. Rev., May 1, 2007; 28(3): 297 - 321.
[Abstract] [Full Text] [PDF]

Home page
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B. Stecca, C. Mas, V. Clement, M. Zbinden, R. Correa, V. Piguet, F. Beermann, and A. Ruiz i Altaba
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
PNAS, April 3, 2007; 104(14): 5895 - 5900.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
F. M. Vaccarino, D. M. Fagel, Y. Ganat, M. E. Maragnoli, L. R. Ment, Y. Ohkubo, M. L. Schwartz, J. Silbereis, and K. M. Smith
Astroglial Cells in Development, Regeneration, and Repair
Neuroscientist, April 1, 2007; 13(2): 173 - 185.
[Abstract] [PDF]

Home page
 DevelopmentHome page
R. C. Moraes, X. Zhang, N. Harrington, J. Y. Fung, M.-F. Wu, S. G. Hilsenbeck, D. C. Allred, and M. T. Lewis
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
Development, March 15, 2007; 134(6): 1231 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Menuet, A. Alunni, J.-S. Joly, W. R. Jeffery, and S. Retaux
Expanded expression of Sonic Hedgehog in Astyanax cavefish: multiple consequences on forebrain development and evolution
Development, March 1, 2007; 134(5): 845 - 855.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Chopp, Z. G. Zhang, and Q. Jiang
Neurogenesis, Angiogenesis, and MRI Indices of Functional Recovery From Stroke
Stroke, February 1, 2007; 38(2): 827 - 831.
[Abstract] [Full Text] [PDF]

Home page
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M. Locker, M. Agathocleous, M. A. Amato, K. Parain, W. A. Harris, and M. Perron
Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors.
Genes & Dev., November 1, 2006; 20(21): 3036 - 3048.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Evangelista, H. Tian, and F. J. de Sauvage
The hedgehog signaling pathway in cancer.
Clin. Cancer Res., October 15, 2006; 12(20): 5924 - 5928.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.-x. Zhou, L.-w. Jia, W.-m. Liu, C.-l. Miao, S. Liu, Y.-j. Cao, and E.-k. Duan
Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis
Hum. Reprod., July 1, 2006; 21(7): 1698 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. K. Sicklick, Y.-X. Li, A. Melhem, E. Schmelzer, M. Zdanowicz, J. Huang, M. Caballero, J. H. Fair, J. W. Ludlow, R. E. McClelland, et al.
Hedgehog signaling maintains resident hepatic progenitors throughout life
Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G859 - G870.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
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Cell Proliferation in the Adult Hippocampal Formation of Rodents and its Modulation by Entorhinal and Fimbria-Fornix Afferents
Cereb Cortex, March 1, 2006; 16(3): 301 - 312.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
N. Sanai, A. Alvarez-Buylla, and M. S. Berger
Neural Stem Cells and the Origin of Gliomas
N. Engl. J. Med., August 25, 2005; 353(8): 811 - 822.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al.
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Lemasson, A. Saghatelyan, J.-C. Olivo-Marin, and P.-M. Lledo
Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb
J. Neurosci., July 20, 2005; 25(29): 6816 - 6825.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Schnapp, M. Kragl, L. Rubin, and E. M. Tanaka
Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration
Development, July 15, 2005; 132(14): 3243 - 3253.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba
Cooperative requirement of the Gli proteins in neurogenesis
Development, July 15, 2005; 132(14): 3267 - 3279.
[Abstract] [Full Text] [PDF]


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