spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 5 Jan 2005
doi: 10.1242/dev.01599

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01599v1
132/3/591    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Birsoy, B.
Right arrow Articles by Heasman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Birsoy, B.
Right arrow Articles by Heasman, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGF{beta} proteins in Xenopus development


Bilge Birsoy, Linnea Berg, P. Huw Williams, James C. Smith, Christopher C. Wylie, Jan L. Christian, and Janet Heasman*
* Author for correspondence (e-mail: heabq9{at}chmcc.org)

XPACE4 is a member of the subtilisin/kexin family of pro-protein convertases. It cleaves many pro-proteins to release their active proteins, including members of the TGF{beta} family of signaling molecules. Studies in mouse suggest it may have important roles in regulating embryonic tissue specification. Here, we examine the role of XPACE4 in Xenopus development and make three novel observations: first, XPACE4 is stored as maternal mRNA localized to the mitochondrial cloud and vegetal hemisphere of the oocyte; second, it is required for the endogenous mesoderm inducing activity of vegetal cells before gastrulation; and third, it has substrate-specific activity, cleaving Xnr1, Xnr2, Xnr3 and Vg1, but not Xnr5, Derrière or ActivinB pro-proteins. We conclude that maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature TGF{beta} proteins in specific sites.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. M. Nelsen and J. L. Christian
Site-specific Cleavage of BMP4 by Furin, PC6, and PC7
J. Biol. Chem., October 2, 2009; 284(40): 27157 - 27166.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
K. S. Brown, M. D. Blower, T. J. Maresca, T. C. Grammer, R. M. Harland, and R. Heald
Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle
J. Cell Biol., March 12, 2007; 176(6): 765 - 770.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. T. Thomas, D. Prakash, K. Weih, and M. Moos Jr.
CDMP1/GDF5 Has Specific Processing Requirements That Restrict Its Action to Joint Surfaces
J. Biol. Chem., September 8, 2006; 281(36): 26725 - 26733.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Birsoy, M. Kofron, K. Schaible, C. Wylie, and J. Heasman
Vg1 is an essential signaling molecule in Xenopus development
Development, January 1, 2006; 133(1): 15 - 20.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005