spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 19 Jan 2005
doi: 10.1242/dev.01618

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01618v1
132/4/805    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lloyd, B.
Right arrow Articles by Wylie, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lloyd, B.
Right arrow Articles by Wylie, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos


Brett Lloyd, QingHua Tao, Stephanie Lang, and Chris Wylie*
* Author for correspondence (e-mail: christopher.wylie{at}cchmc.org)

The mechanisms that control shape and rigidity of early embryos are not well understood, and yet are required for all embryonic processes to take place. In the Xenopus blastula, the cortical actin network in each blastomere is required for the maintenance of overall embryonic shape and rigidity. However, the mechanism whereby each cell assembles the appropriate pattern and number of actin filament bundles is not known. The existence of a similar network in each blastomere suggests two possibilities: cell-autonomous inheritance of instructions from the egg; or mutual intercellular signaling mediated by cell contact or diffusible signals. We show that intercellular signaling is required for the correct pattern of cortical actin assembly in Xenopus embryos, and that lysophosphatidic acid (LPA) and its receptors, corresponding to LPA1 and LPA2 in mammals, are both necessary and sufficient for this function.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
S. Nandadasa, Q. Tao, N. R. Menon, J. Heasman, and C. Wylie
N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements
Development, April 15, 2009; 136(8): 1327 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F. Lin, S. Chen, D. S. Sepich, J. R. Panizzi, S. G. Clendenon, J. A. Marrs, H. E. Hamm, and L. Solnica-Krezel
G{alpha}12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
J. Cell Biol., March 23, 2009; 184(6): 909 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
X. Ye
Lysophospholipid signaling in the function and pathology of the reproductive system
Hum. Reprod. Update, September 1, 2008; 14(5): 519 - 536.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. Tao, S. Nandadasa, P. D. McCrea, J. Heasman, and C. Wylie
G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo
Development, July 15, 2007; 134(14): 2651 - 2661.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Luo, Y. Xu, T. L. Hoffman, T. Zhang, T. Schilling, and T. D. Sargent
Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development
Development, April 1, 2007; 134(7): 1279 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. Tao, B. Lloyd, S. Lang, D. Houston, A. Zorn, and C. Wylie
A novel G protein-coupled receptor, related to GPR4, is required for assembly of the cortical actin skeleton in early Xenopus embryos
Development, June 15, 2005; 132(12): 2825 - 2836.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005