spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 12 Jan 2005
doi: 10.1242/dev.01636

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01636v1
132/4/667    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Han, C.
Right arrow Articles by Lin, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Han, C.
Right arrow Articles by Lin, X.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc


Chun Han, Dong Yan, Tatyana Y. Belenkaya, and Xinhua Lin*
* Author for correspondence (e-mail: xinhua.lin{at}cchmc.org)

Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning. The molecular mechanism(s) of Wg gradient formation is not fully understood. Here, we systematically analyzed the roles of glypicans Dally and Dally-like protein (Dlp), the Wg receptors Frizzled (Fz) and Fz2, and the Wg co-receptor Arrow (Arr) in Wg gradient formation in the wing disc. We demonstrate that both Dally and Dlp are essential and have different roles in Wg gradient formation. The specificities of Dally and Dlp in Wg gradient formation are at least partially achieved by their distinct expression patterns. To our surprise, although Fz2 was suggested to play an essential role in Wg gradient formation by ectopic expression studies, removal of Fz2 activity does not alter the extracellular Wg gradient. Interestingly, removal of both Fz and Fz2, or Arr causes enhanced extracellular Wg levels, which is mainly resulted from upregulated Dlp levels. We further show that Notum, a negative regulator of Wg signaling, downregulates Wg signaling mainly by modifying Dally. Last, we demonstrate that Wg movement is impeded by cells mutant for both dally and dlp. Together, these new findings suggest that the Wg morphogen gradient in the wing disc is mainly controlled by combined actions of Dally and Dlp. We propose that Wg establishes its concentration gradient by a restricted diffusion mechanism involving Dally and Dlp in the wing disc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cold Spring Harb. Perspect. Biol.Home page
O. Wartlick, A. Kicheva, and M. Gonzalez-Gaitan
Morphogen Gradient Formation
Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a001255 - a001255.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb. Perspect. Biol.Home page
D. Yan and X. Lin
Shaping Morphogen Gradients by Proteoglycans
Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a002493 - a002493.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb. Perspect. Biol.Home page
K. M. Cadigan and M. Peifer
Wnt Signaling from Development to Disease: Insights from Model Systems
Cold Spring Harb Perspect Biol, August 1, 2009; 1(2): a002881 - a002881.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb. Perspect. Biol.Home page
A. D. Lander, W.-C. Lo, Q. Nie, and F. Y.M. Wan
The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning
Cold Spring Harb Perspect Biol, July 1, 2009; 1(1): a002022 - a002022.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Shao, Z.-Z. Liu, C.-D. Wang, H.-Y. Li, C. Carron, H.-W. Zhang, and D.-L. Shi
Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos
Development, June 15, 2009; 136(12): 2121 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
R. Nusse, C. Fuerer, W. Ching, K. Harnish, C. Logan, A. Zeng, D. ten Berge, and Y. Kalani
Wnt Signaling and Stem Cell Control
Cold Spring Harb Symp Quant Biol, November 26, 2008; (2008) sqb.2008.73.035v2.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Baena-Lopez, I. Rodriguez, and A. Baonza
The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like
PNAS, July 15, 2008; 105(28): 9645 - 9650.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J.C Smith, A Hagemann, Y Saka, and P.H Williams
Understanding how morphogens work
Phil Trans R Soc B, April 12, 2008; 363(1495): 1387 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. J. Bornemann, S. Park, S. Phin, and R. Warrior
A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo
Development, March 15, 2008; 135(6): 1039 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Green, T. Inoue, and P. W. Sternberg
The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway
Development, November 15, 2007; 134(22): 4053 - 4062.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ueda, R. Yamaguchi, M. Ikawa, M. Okabe, E. Morii, Y. Maeda, and T. Kinoshita
PGAP1 Knock-out Mice Show Otocephaly and Male Infertility
J. Biol. Chem., October 19, 2007; 282(42): 30373 - 30380.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. M. Galli, T. L. Barnes, S. S. Secrest, T. Kadowaki, and L. W. Burrus
Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube
Development, September 15, 2007; 134(18): 3339 - 3348.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. A. Kirkpatrick and S. B. Selleck
Heparan sulfate proteoglycans at a glance
J. Cell Sci., June 1, 2007; 120(11): 1829 - 1832.
[Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zhu, L. M. Stevens, and D. Stein
Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation
Development, April 15, 2007; 134(8): 1465 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. M. Smallwood, J. Williams, Q. Xu, D. J. Leahy, and J. Nathans
Mutational Analysis of Norrin-Frizzled4 Recognition
J. Biol. Chem., February 9, 2007; 282(6): 4057 - 4068.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Julicher, and M. Gonzalez-Gaitan
Kinetics of Morphogen Gradient Formation
Science, January 26, 2007; 315(5811): 521 - 525.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. A. Crickmore and R. S. Mann
Hox control of morphogen mobility and organ development through regulation of glypican expression
Development, January 15, 2007; 134(2): 327 - 334.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Coudreuse and H. C. Korswagen
The making of Wnt: new insights into Wnt maturation, sorting and secretion
Development, January 1, 2007; 134(1): 3 - 12.
[Full Text] [PDF]

Home page
 DevelopmentHome page
R. M. Goodman, S. Thombre, Z. Firtina, D. Gray, D. Betts, J. Roebuck, E. P. Spana, and E. M. Selva
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
Development, December 15, 2006; 133(24): 4901 - 4911.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H.-Y. Lim and A. Tomlinson
Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis
Development, September 15, 2006; 133(18): 3529 - 3537.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
S. B. Selleck
Shedding Light on the Distinct Functions of Proteoglycans
Sci. Signal., April 4, 2006; 2006(329): pe17 - pe17.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Callejo, C. Torroja, L. Quijada, and I. Guerrero
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
Development, February 1, 2006; 133(3): 471 - 483.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Marois, A. Mahmoud, and S. Eaton
The endocytic pathway and formation of the Wingless morphogen gradient
Development, January 15, 2006; 133(2): 307 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. I. Capurro, W. Shi, S. Sandal, and J. Filmus
Processing by Convertases Is Not Required for Glypican-3-induced Stimulation of Hepatocellular Carcinoma Growth
J. Biol. Chem., December 16, 2005; 280(50): 41201 - 41206.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Piddini, F. Marshall, L. Dubois, E. Hirst, and J.-P. Vincent
Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs
Development, December 15, 2005; 132(24): 5479 - 5489.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005