spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 19 Jan 2005
doi: 10.1242/dev.01638

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01638v1
132/4/739    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cassata, G.
Right arrow Articles by Baumeister, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cassata, G.
Right arrow Articles by Baumeister, R.

Research article

ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans


Giuseppe Cassata, Gidi Shemer, Paolo Morandi, Roland Donhauser, Benjamin Podbilewicz, and Ralf Baumeister*
* Author for correspondence (e-mail: baumeister{at}celegans.de)

engrailed is a homeobox gene essential for developmental functions such as differentiation of cell populations and the onset of compartment boundaries in arthropods and vertebrates. We present the first functional study on engrailed in an unsegmented animal: the nematode Caenorhabditis elegans. In the developing worm embryo, ceh-16/engrailed is predominantly expressed in one bilateral row of epidermal cells (the seam cells). We show that ceh-16/engrailed primes a specification cascade through three mechanisms: (1) it suppresses fusion between seam cells and other epidermal cells by repressing eff-1/fusogen expression; (2) it triggers the differentiation of the seam cells through different factors, including the GATA factor elt-5; and (3) it segregates the seam cells into a distinct lateral cellular compartment, repressing cell migration toward dorsal and ventral compartments.


This article has been cited by other articles:


Home page
 DevelopmentHome page
B. Yi and R. J. Sommer
The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39
Development, September 1, 2007; 134(17): 3111 - 3119.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. Margalit, E. Neufeld, N. Feinstein, K. L. Wilson, B. Podbilewicz, and Y. Gruenbaum
Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans
J. Cell Biol., August 9, 2007; 178(4): 661 - 673.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Diogon, F. Wissler, S. Quintin, Y. Nagamatsu, S. Sookhareea, F. Landmann, H. Hutter, N. Vitale, and M. Labouesse
The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis
Development, July 1, 2007; 134(13): 2469 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Gattegno, A. Mittal, C. Valansi, K. C.Q. Nguyen, D. H. Hall, L. V. Chernomordik, and B. Podbilewicz
Genetic Control of Fusion Pore Expansion in the Epidermis of Caenorhabditis elegans
Mol. Biol. Cell, April 1, 2007; 18(4): 1153 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. A. Smith, P. McGarr, and J. S. Gilleard
The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion
J. Cell Sci., December 15, 2005; 118(24): 5709 - 5719.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005