spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 30 Mar 2005
doi: 10.1242/dev.01795

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01795v1
132/9/2157    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mailleux, A. A.
Right arrow Articles by Bellusci, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mailleux, A. A.
Right arrow Articles by Bellusci, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage


Arnaud A. Mailleux, Robert Kelly, Jacqueline M. Veltmaat, Stijn P. De Langhe, Stephane Zaffran, Jean Paul Thiery, and Saverio Bellusci*
* Author for correspondence (e-mail: sbellusci{at}chla.usc.edu)

Lineage formation in the lung mesenchyme is poorly understood. Using a transgenic mouse line expressing LacZ under the control of Fgf10 regulatory sequences, we show that the pool of Fgf10-positive cells in the distal lung mesenchyme contains progenitors of the parabronchial smooth muscle cells. Fgf10 gene expression is slightly repressed in this transgenic line. This allowed us to create a hypomorphic Fgf10 phenotype by expressing the LacZ transgene in a heterozygous Fgf10 background. Hypomorphic Fgf10 mutant lungs display a decrease in {beta}-galactosidase-positive cells around the bronchial epithelium associated with an accumulation of {beta}-galactosidase-expressing cells in the distal mesenchyme. This correlates with a marked reduction of {alpha} smooth muscle actin expression, thereby demonstrating that FGF10 is mostly required for the entry of mesenchymal cells into the parabronchial smooth muscle cell lineage. The failure of exogenous FGF10 to phosphorylate its known downstream targets ERK and AKT in lung mesenchymal cultures strongly suggests that FGF10 acts indirectly on the progenitor population via an epithelial intermediate. We provide support for a role of epithelial BMP4 in mediating the formation of parabronchial smooth muscle cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
W. Shi, F. Chen, and W. V. Cardoso
Mechanisms of Lung Development: Contribution to Adult Lung Disease and Relevance to Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, December 1, 2009; 6(7): 558 - 563.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E C Jesudason
Airway smooth muscle: an architect of the lung?
Thorax, June 1, 2009; 64(6): 541 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Li, C. Li, Y.-h. Liu, Y. Xing, L. Hu, Z. Borok, K. Y.-C. Kwong, and P. Minoo
Mesodermal Deletion of Transforming Growth Factor-{beta} Receptor II Disrupts Lung Epithelial Morphogenesis: CROSS-TALK BETWEEN TGF-{beta} AND SONIC HEDGEHOG PATHWAYS
J. Biol. Chem., December 26, 2008; 283(52): 36257 - 36264.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. Warburton, L. Perin, R. DeFilippo, S. Bellusci, W. Shi, and B. Driscoll
Stem/Progenitor Cells in Lung Development, Injury Repair, and Regeneration
Proceedings of the ATS, August 15, 2008; 5(6): 703 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. H. Kariyawasam, G. Xanthou, J. Barkans, M. Aizen, A. B. Kay, and D. S. Robinson
Basal Expression of Bone Morphogenetic Protein Receptor Is Reduced in Mild Asthma
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1074 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
K. R. Badri, Y. Zhou, and L. Schuger
Embryological Origin of Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. Murphy, R. Summer, and A. Fine
Stem Cells in Airway Smooth Muscle: State of the Art
Proceedings of the ATS, January 1, 2008; 5(1): 11 - 14.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. C. White, K. J. Lavine, and D. M. Ornitz
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network
Development, October 15, 2007; 134(20): 3743 - 3752.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Santos, R. S. Moura, S. Gonzaga, C. Nogueira-Silva, S. Ohlmeier, and J. Correia-Pinto
Embryonic Essential Myosin Light Chain Regulates Fetal Lung Development in Rats
Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 330 - 338.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Chen, T. J. Desai, J. Qian, K. Niederreither, J. Lu, and W. V. Cardoso
Inhibition of Tgf{beta} signaling by endogenous retinoic acid is essential for primary lung bud induction
Development, August 15, 2007; 134(16): 2969 - 2979.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
W. Shi, S. Bellusci, and D. Warburton
Lung Development and Adult Lung Diseases
Chest, August 1, 2007; 132(2): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Natanson-Yaron, E. Y. Anteby, C. Greenfield, D. Goldman-Wohl, Y. Hamani, D. Hochner-Celnikier, and S. Yagel
FGF 10 and Sprouty 2 modulate trophoblast invasion and branching morphogenesis
Mol. Hum. Reprod., July 1, 2007; 13(7): 511 - 519.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. T. Benjamin, R. J. Smith, B. A. Halloran, T. J. Day, D. R. Kelly, and L. S. Prince
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation
Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L550 - L558.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Maeda, V. Dave, and J. A. Whitsett
Transcriptional Control of Lung Morphogenesis
Physiol Rev, January 1, 2007; 87(1): 219 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. C. Featherstone, M. G. Connell, D. G. Fernig, S. Wray, T. V. Burdyga, P. D. Losty, and E. C. Jesudason
Airway Smooth Muscle Dysfunction Precedes Teratogenic Congenital Diaphragmatic Hernia and May Contribute to Hypoplastic Lung Morphogenesis
Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 571 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
I. Mandeville, J. Aubin, M. LeBlanc, M. Lalancette-Hebert, M.-F. Janelle, G. M. Tremblay, and L. Jeannotte
Impact of the Loss of Hoxa5 Function on Lung Alveogenesis
Am. J. Pathol., October 1, 2006; 169(4): 1312 - 1327.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. C. Jesudason, N. P. Smith, M. G. Connell, D. G. Spiller, M. R. H. White, D. G. Fernig, and P. D. Losty
Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth
Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L559 - L565.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. M. Veltmaat, F. Relaix, L. T. Le, K. Kratochwil, F. G. Sala, W. van Veelen, R. Rice, B. Spencer-Dene, A. A. Mailleux, D. P. Rice, et al.
Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
Development, June 15, 2006; 133(12): 2325 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. V. Cardoso and J. Lu
Regulation of early lung morphogenesis: questions, facts and controversies
Development, May 1, 2006; 133(9): 1611 - 1624.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. C. White, J. Xu, Y. Yin, C. Smith, G. Schmid, and D. M. Ornitz
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
Development, April 15, 2006; 133(8): 1507 - 1517.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005