spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 3 Aug 2005
doi: 10.1242/dev.01949

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01949v1
132/17/3935    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McEwen, D. G.
Right arrow Articles by Peifer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McEwen, D. G.
Right arrow Articles by Peifer, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis


Donald G. McEwen* and Mark Peifer
* Author for correspondence (e-mail: mcewen{at}uthscsa.edu)

MAPK phosphatases (MKPs) are important negative regulators of MAPKs in vivo, but ascertaining the role of specific MKPs is hindered by functional redundancy in vertebrates. Thus, we characterized MKP function by examining the function of Puckered (Puc), the sole Drosophila Jun N-terminal kinase (JNK)-specific MKP, during embryonic and imaginal disc development. We demonstrate that Puc is a key anti-apoptotic factor that prevents apoptosis in epithelial cells by restraining basal JNK signaling. Furthermore, we demonstrate that JNK signaling plays an important role in {gamma}-irradiation-induced apoptosis, and examine how JNK signaling fits into the circuitry regulating this process. Radiation upregulates both JNK activity and puc expression in a p53-dependent manner, and apoptosis induced by loss of Puc can be suppressed by p53 inactivation. JNK signaling acts upstream of both Reaper and effector caspases. Finally, we demonstrate that JNK signaling directs normal developmentally regulated apoptotic events. However, if cell death is prevented, JNK activation can trigger tissue overgrowth. Thus, MKPs are key regulators of the delicate balance between proliferation, differentiation and apoptosis during development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
L. M. McNamee and M. H. Brodsky
p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy
Genetics, June 1, 2009; 182(2): 423 - 435.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Ziv, Y. Suissa, H. Neuman, T. Dinur, P. Geuking, C. Rhiner, M. Portela, F. Lolo, E. Moreno, and O. Gerlitz
The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling
Development, April 1, 2009; 136(7): 1137 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Perez-Garijo, E. Shlevkov, and G. Morata
The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
Development, April 1, 2009; 136(7): 1169 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. J. Griswold, K. T. Chang, A. P. Runko, M. A. Knight, and K.-T. Min
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila
PNAS, June 24, 2008; 105(25): 8673 - 8678.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. J. Krieser, F. E. Moore, D. Dresnek, B. J. Pellock, R. Patel, A. Huang, C. Brachmann, and K. White
The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis
Development, July 1, 2007; 134(13): 2407 - 2414.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
W. Liu, A. M. Silverstein, H. Shu, B. Martinez, and M. C. Mumby
A Functional Genomics Analysis of the B56 Isoforms of Drosophila Protein Phosphatase 2A
Mol. Cell. Proteomics, February 1, 2007; 6(2): 319 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Balakireva, C. Rosse, J. Langevin, Y.-c. Chien, M. Gho, G. Gonzy-Treboul, S. Voegeling-Lemaire, S. Aresta, J.-A. Lepesant, Y. Bellaiche, et al.
The Ral/Exocyst Effector Complex Counters c-Jun N-Terminal Kinase-Dependent Apoptosis in Drosophila melanogaster
Mol. Cell. Biol., December 1, 2006; 26(23): 8953 - 8963.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Singh, X. Shi, and K.-W. Choi
Lobe and Serrate are required for cell survival during early eye development in Drosophila.
Development, December 1, 2006; 133(23): 4771 - 4781.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Kondo, N. Senoo-Matsuda, Y. Hiromi, and M. Miura
DRONC Coordinates Cell Death and Compensatory Proliferation.
Mol. Cell. Biol., October 1, 2006; 26(19): 7258 - 7268.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Polaski, L. Whitney, B. W. Barker, and B. Stronach
Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development
Genetics, October 1, 2006; 174(2): 719 - 733.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005